2795-76-8

Usage

Uses

Used in Pharmaceutical Research:
(4-Chlorophenyl)(4-fluorophenyl)Methanol is used as a potential intermediate in the synthesis of various medications. Its unique structure allows for the creation of diverse pharmaceutical compounds, contributing to the development of new drugs and therapies.
Used in Organic Chemistry:
(4-Chlorophenyl)(4-fluorophenyl)Methanol serves as a building block in the production of other organic compounds. Its chlorophenyl and fluorophenyl groups provide a foundation for further chemical reactions and the synthesis of more complex molecules.
Used in Pharmacological Studies:
(4-Chlorophenyl)(4-fluorophenyl)Methanol is also studied for its potential pharmacological properties. Researchers are interested in understanding how (4-Chlorophenyl)(4-fluorophenyl)Methanol interacts with biological systems and whether it can be used to develop new treatments for various medical conditions.
Safety Precautions:
It is important to handle (4-Chlorophenyl)(4-fluorophenyl)Methanol with care due to its potential risks and hazards. As with all chemicals, it should be used according to safety guidelines and procedures to ensure the safety of both the users and the environment.

Upstream product

• 459-57-4 4-fluorobenzaldehyde 
• 1765-93-1 4-fluoroboronic acid 
• 104-88-1 4-chlorobenzaldehyde 
• 448-59-9 tris(4-fluorophenyl)boroxine 
• 108-90-7 chlorobenzene 
• 403-43-0 4-fluorobenzoyl chloride 
• 460-00-4 1-Bromo-4-fluorobenzene 
• 352-13-6 4-flourophenylmagnesium bromide 
• 873-77-8 (4-chlorphenyl)magnesium bromide 
• 2069-48-9 4-chloro-4'-fluoro-benzophenone 

Downstream Products

• 3801-53-4 (4-chlorophenyl)-4-fluorophenylmethane 
• 1202767-54-1 3-[(4-Chlorophenyl)(4-fluorophenyl)methyl]-7-[(methylsulfanyl)methyl]-1H-indole 
• 64583-42-2 1-(bromo(4-chlorophenyl)methyl)-4-fluorobenzene 
• 64583-39-7 (p-chlorophenyl)-(p-fluorophenyl)methyl chloride 
• 76778-35-3 1-chloro-4-<(2-chloroethoxy)(4-fluorophenyl)methyl>benzene 

Relevant academic research and scientific papers

[Ir(COD)Cl]2/tris(2,4-di-t-butylphenyl)phosphite-catalyzed addition reactions of arylboronic acids with aldehydes

[Ir(COD)Cl]2/tris(2,4-di-t-butylphenyl)phosphite-catalyzed addition reactions of arylboronic acids with aldehydes were described. The Ir(I) catalyst, generated from [Ir(COD)Cl]2 and tris(2,4-di-t-butylphenyl)phosphite, was an efficient catalyst system for the addition reactions of a variety of arylboronic acids with aromatic and aliphatic aldehydes. The easy availability of the catalyst and good yields make these reactions potentially useful in organic synthesis.

The arylation of aldehydes with arylboronic acids using metal-organic framework Ni(HBTC)BPY as an efficient heterogeneous catalyst

A highly crystalline porous Ni(HBTC)BPY was synthesized from the reaction of 1,3,5-benzenetricarboxylic acid, nickel nitrate hexahydrate, and 4,4′-bipyridine by a solvothermal method. Physical characterizations of the solid catalyst were achieved by using several techniques, including X-ray powder diffraction (XRD), scanning electron microscope (SEM), transmission electron microscopy (TEM), thermogravimetric analysis (TGA), Fourier transform infrared (FT-IR), atomic absorption spectrophotometry (AAS), and nitrogen physisorption measurements. The Ni(HBTC)BPY exhibited high catalytic activity in the arylation of aldehydes with arylboronic acids to form diarylmethanols. The catalyst could be separated from the reaction mixture by simple filtration or centrifugation, and could be reused without a significant degradation in catalytic activity. No contribution from homogeneous catalysis of active species leaching into the liquid phase was detected.

CuCl/bipyridine-catalyzed addition reactions of arylboroxines with aldehydes, α,β-unsaturated ketones, and N-tosyl aldimines

CuCl/bipyridine-catalyzed addition reactions of arylboroxines with aldehydes and α,β-unsaturated ketones at elevated temperatures were described. By using the microwave energy, CuCl/bipyridine-catalyzed addition reactions of arylboroxines with aldimines were also realized.

Microwave-assisted nickel(II) acetylacetonate-catalyzed arylation of aldehydes with arylboronic acids

Applying sealed vessel microwave heating at 180 °C in toluene the arylation of aromatic and aliphatic aldehydes with arylboronic acids using 1-2 mol % of Ni(acac)2 as a catalyst can be performed efficiently within 10-30 min providing the desired diarylmethanols or benzyl alcohols in good yields.

Carbinol derivatives via rhodium-catalyzed addition of potassium trifluoro(organo)borates to aldehydes

Reaction of potassium aryltrifluoroborates with aldehydes, in the presence of a rhodium catalyst, afforded carbinol derivatives in high yields under mild aqueous conditions; this efficient reaction proved to be general, allowing the production of highly hindered diarylmethanols and aliphatic aldehydes were also reactive under these conditions. The Royal Society of Chemistry 2005.

BENZENE DERIVATIVES,PROCESS FOR PREPARING THE SAME AND USE THEREOF

Novel benzene derivatives represented by the formula (I) : wherein R1, R4 and R6 each independently represents a hydrogen atom, a halogen atom or a hydrocarbon group, R2 represents a hydrocarbon group or a heterocyclic group, R3 represents a hydrocarbon group, NR7'R7 or OR8 (wherein R7' represents a hydrogen atom or a hydrocarbon group, R7 represents a non-aromatic group, or R7' and R7 may form a ring with the adjacent nitrogen atom, and R8 represents a hydrocarbon group or a heterocyclic group), R5 represents a hydrocarbon group or a heterocyclic group (except for a quinolyl group), R5' represents a hydrogen atom, or a hydrocarbon group, or R5 and R5' may form a ring with the adjacent nitrogen atom, and R5" represents a hydrogen atom or a hydrocarbon group, which have vanilloid receptor agonist activity and are useful as a drug such as an analgesic and an agent for preventing and/or treating urinary frequency and/or urinary incontinence.