279684-18-3Relevant academic research and scientific papers
Short synthesis of 4-chloro-4′-(chlorodifluoromethoxy)benzophenone
Karrer, Friedrich,Meier, Hans,Pascual, Alfons
, p. 81 - 84 (2000)
A one-pot, highly selective synthesis of 4-chloro-4′-(chlorodifluoromethoxy)benzophenone suitable for an industrial scale-up was developed. Fluorination of 4-(trichloromethoxy)benzoyl chloride at -20°C with HF to 4-(chlorodifluoromethoxy)benzoyl fluoride followed by an in situ Friedel-Crafts reaction with chlorobenzene in the presence of BF3 at -5°C yielded the title compound in excellent yield.
Synthesis and structure-activity relationships of benzophenone hydrazone derivatives with insecticidal activity
Boeger, Manfred,Duerr, Dieter,Gsell, Laurenz,Hall, Roger G.,Karrer, Friedrich,Kristiansen, Odd,Maienfisch, Peter,Pascual, Alfons,Rindlisbacher, Alfred
, p. 191 - 202 (2007/10/03)
A broad range of benzophenone hydrazone derivatives was prepared and tested against selected chewing insect pests, allowing the analysis of structure-activity relationships. Good activity was found only when the aromatic rings were substituted at the 4-positions with an halogen atom and a triflate or perhaloalkoxy group. In contrast, a number of substituents on the hydrazone part led to active compounds, the best results being achieved with acyl-type substituents. The excellent laboratory and greenhouse activity of the best representatives was confirmed in semi-field trials against Spodoptera littoralis. ° 2001 Society of Chemical Industry.
