36823-89-9Relevant articles and documents
Short synthesis of 4-chloro-4′-(chlorodifluoromethoxy)benzophenone
Karrer, Friedrich,Meier, Hans,Pascual, Alfons
, p. 81 - 84 (2007/10/03)
A one-pot, highly selective synthesis of 4-chloro-4′-(chlorodifluoromethoxy)benzophenone suitable for an industrial scale-up was developed. Fluorination of 4-(trichloromethoxy)benzoyl chloride at -20°C with HF to 4-(chlorodifluoromethoxy)benzoyl fluoride followed by an in situ Friedel-Crafts reaction with chlorobenzene in the presence of BF3 at -5°C yielded the title compound in excellent yield.