27970-50-9

Usage

Uses

Used in Pharmaceutical Industry:
3-N-Pentyl-2,4-pentanedione is used as a reagent for the synthesis of thiazolidin-4-ones, which are known as HIV-1 reverse transcriptase inhibitors. These inhibitors play a crucial role in the development of antiretroviral drugs, as they help in the treatment and management of HIV/AIDS by blocking the replication of the virus.
In the synthesis process, 3-N-pentyl-2,4-pentanedione serves as a key intermediate, contributing to the formation of the thiazolidin-4-one ring structure. The compound's diketone functionality is particularly important, as it allows for the formation of the desired ring through a series of chemical reactions.
The use of 3-N-pentyl-2,4-pentanedione in the pharmaceutical industry highlights its potential as a valuable compound in the development of life-saving medications. Its role in the synthesis of HIV-1 reverse transcriptase inhibitors demonstrates its importance in the ongoing fight against HIV/AIDS and contributes to the advancement of medical research in this field.

InChI:InChI=1/C10H18O2/c1-4-5-6-7-10(8(2)11)9(3)12/h10H,4-7H2,1-3H3

Upstream product

• 36960-12-0 (E)-2-acetoxy-2-heptene 
• 16630-91-4 2-methylheptanal 
• 108-24-7 acetic anhydride 
• 7637-07-2 boron trifluoride 
• 111-13-7 hexyl-methyl-ketone 
• 628-17-1 amyl iodide 
• 123-54-6 acetylacetone 
• 110-53-2 1-Bromopentane 

Relevant academic research and scientific papers

Synthesis and Properties of 4,6-Dimethyl-5-pentyl-2-thioxo-1,2-dihydropyridine-3-carbonitrile and 3-Amino-4,6-dimethyl-5-pentylthieno[2,3-b]pyridines

The reaction of 3-pentylpentane-2,4-dione with cyanothioacetamide afforded 4,6-dimethyl-5-pentyl-2-thioxo-1,2-dihydropyridine-3-carbonitrile. Alkylation of the latter led to the formation of 2-alkylsulfanyl-4,6-dimethyl-5-pentylpyridine-3-carbonitriles or 3-amino-4,6-dimethyl-5-pentylthieno[2,3-b]pyridines, depending on the alkylating agent and reaction conditions. The structures of the key compounds were proved by 2D NMR spectroscopy and X-ray analysis. Biological activity of the synthesized compounds was evaluated in silico. Some compounds were experimentally found to stimulate growth of sunflower seedlings.

High-yielding synthesis of β-octaalkyl-meso-(bromophenyl)-substituted porphyrins and X-ray study of axial complexes of their zinc complexes with THF and 1,4-dioxane

New 5-(4-bromophenyl)-3,7,12,13,17,18-hexamethyl-2,8-dipentyl- and 5,15-bis(4-bromophenyl)-2,8,12,18-tetramethyl-2,8,12,18-tetrapentylporphyrins (H2P-1 and H2P-2) and their zinc metal complexes (ZnP-1 and ZnP-2, respectively) were sy