27975-99-1Relevant academic research and scientific papers
Phenyl-substituted normethadones: Synthesis and pharmacology
Mbela,Poupaert,Cumps,Moussebois,Haemers,Borloo,Dumont
, p. 237 - 242 (2007/10/02)
Phenyl-substituted normethadone derivatives were synthesized and their affinity (IC50) for opioid receptors was determined by displacement of the specific binding sites of [3H]sufentanyl on rat brain preparations. Substitution resulted in a decrease of affinity in-vitro. These results suggest that normethadone-like compounds may interact with the P subsite of the μ-opioid receptor and that the P subsite has a well-defined cavity shape of stringent dimensions.
