28002-72-4Relevant academic research and scientific papers
Palladium-Catalyzed β-Mesylation of Simple Amide via Primary sp3 C-H Activation
Zhao, Ren,Lu, Wenjun
, p. 1768 - 1771 (2017/04/11)
A β-mesylation of primary sp3 C-H bonds from simple amides with methanesulfonic anhydride (Ms2O) has been established successfully at 80 °C in a Pd(OAc)2 (catalyst)/K2S2O8 (oxidant)/CF3CH2OH (solvent) system. These amide substrates involve N-monosubstituted linear, branch, or cyclic alkanes, and electron-deficient benzyl compounds. The β-mesylated amide products can be converted easily to β-fluoroamides or β-lactams through inter- or intramolecular SN2 processes.
A Convenient Synthesis of 4-Unsubstituted β-Lactams
Overman, Larry E.,Osawa, Tatsushi
, p. 1698 - 1701 (2007/10/02)
The reaction of lithium ester enolates with N-(cyanomethyl)amines affords 4-unsubstituted β-lactams in good yields, see eq 1.The N-1 substituent can be varied widely, as can the C-3 substituents, which can be H, alkyl, SPh, NH2, or NHCOR.The preparation o
