1074-58-4

Upstream product

• 7677-24-9 trimethylsilyl cyanide 
• 6281-14-7 1,3,5-tricyclohexyl-[1,3,5]triazinane 
• 108-91-8 cyclohexylamine 
• 590-17-0 cyanomethyl bromide 
• 773837-37-9 sodium cyanide 
• 50-00-0 formaldehyd 
• 107-14-2 chloroacetonitrile 
• 151-50-8 potassium cyanide 
• 126541-65-9 N-(benzotriazol-1-yl-methyl)-cyclohexylamine 
• 100-60-7 N-methylcyclohexylamine 
• 143-33-9 sodium cyanide 
• 74-90-8 hydrogen cyanide 
• 4998-76-9 cyclohexylamine hydrochloride 
• 60-29-7 diethyl ether 

Downstream Products

• 854705-58-1 N-cyclohexyl-N-formyl-glycine methyl ester 
• 58695-41-3 N-cyclohexylglycine 
• 85996-91-4 2-cyclohexylamino-acetamide oxime 
• 86198-24-5 N-cyano-N-cyclohexyl-glycine nitrile 
• 100-60-7 N-methylcyclohexylamine 
• 5700-53-8 N-cyclohexylethylenediamine 
• 39150-86-2 [(Z)-Cyclohexylimino]-acetonitrile 
• 39150-86-2 [(E)-Cyclohexylimino]-acetonitrile 
• 87051-22-7 N-cyclohexyl-N-methacryloyl-glycine nitrile 
• 29396-39-2 3-cyclohexyl-5-sydnone imine hydrochloride 
• 39148-06-6 N,N'-Dicyclohexylaminomaleonitril 
• 39150-89-5 2,3-Bis(cyclohexylamino)-2-cyanobernsteinsaeuredinitril 
• 39148-04-4 N-Cyclohexyldiaminomaleinsaeuredinitril 
• 117039-56-2 N-cyclohexyl-N-nitroso-glycine 

Relevant academic research and scientific papers

Heterocycle Syntheses with Anionic N-Heterocyclic Carbenes: Ring Transformations of Sydnone Imine Anions

Sydnone imines were deprotonated at the C4 position to give lithium-stabilized anions, which proved to be stable for several months in solution. These anions are elements of the intersection of the substance classes of N-heterocyclic carbenes and mesomeric betaines. They can be formulated as anionic N-heterocyclic carbenes. The negative charge translates into high-field shifts of the 13C NMR resonance frequencies of C4 in comparison to other NHCs. Similar to the chemistry of N-heterocyclic carbenes, reactions with isocyanates and isothiocyanates gave 4-(N-carbamoyl)-benzoylsydnone imines in trapping reactions. As a result of ring transformations involving the characteristic π-architecture of the mesoionic framework, imidazolidine-2,4-dithiones, imidazolin-2,4-diones and 1,2,4-triazol-5-ones were formed depending on the substitution pattern of the starting materials and the reaction conditions.

Dynamics in Catalytic Asymmetric Diastereoconvergent (3 + 2) Cycloadditions with Isomerizable Nitrones and α-Keto Ester Enolates

Reaction design in asymmetric catalysis has traditionally been predicated on a structurally robust scaffold in both substrates and catalysts, to reduce the number of possible diastereomeric transition states. Herein, we present the stereochemical dynamics in the Ni(II)-catalyzed diastereoconvergent (3 + 2) cycloadditions of isomerizable nitrile-conjugated nitrones with α-keto ester enolates. Even in the presence of multiple equilibrating species, the catalytic protocol displays a wide substrate scope to access a range of CN-containing building blocks bearing adjacent stereocenters with high enantio- and diastereoselectivities. Our computational investigations suggest that the enantioselectivity is governed in the deprotonation process to form (Z)-Ni-enolates, while the unique syn addition is mainly controlled by weak noncovalent bonding interactions between the nitrone and ligand.

REGULATORS FOR CONTROLLING LINEAR AND PSEUDO-RING EXPANSION POLYMERIZATION OF VINYL MONOMERS

The invention concerns new regulator compounds for a novel polymerization process for vinyl monomers, which yields polymers with improved control over composition and nearly full to full conservation of architectural integrity up to high conversion. The regulator compounds are defined by according to anyone of the Formulas (1A), (1B), (1C), (1D), (1E), (1F), (1G), (1H) and (1I), wherein R1 stands for an optionally substituted secondary or tertiary alkyl or secondary or tertiary aralkyl; Z1 stands for -CN or a carboxylic acid ester of formula C(O)OR21; Z2 may be chosen from the group of -CN, carboxylic acid, salts of carboxylic acids, carboxylic acid ester, carboxylic acid amides, (hetero)aryl, alkenyl and halogen; R2, R3, R4 and R5 are each independently chosen from the group of H, alkyl, aralkyl, (hetero)aryl, -CN and carboxylic acid ester of formula C(O)OR22; R7 stands for a primary alkyl or primary aralkyl, -CN or hydrogen; Y stands for a bridging group and n is 2, 3, 4, 5 or 6; in case R1 stands for tertiary alkyl or tertiary aralkyl, R6 stands for a primary alkyl or primary aralkyl, -CN or a carboxylic acid ester of formula C(O)OR26; in case R1 stands for a secondary alkyl or secondary aralkyl, R6 stands for a primary or secondary alkyl or primary or secondary aralkyl, -CN, a carboxylic acid ester of formula C(O)OR26 or a phosphonic acid ester of formula P(O)(OR27)2, a (hetero)aryl or an alkenyl; R21, R22, R26 and R27 each independently stand for alkyl or aralkyi having from 1-30 carbon atoms, optionally containing heteroatoms.

NOVEL 2-AMINO-QUINAZOLINE DERIVATIVES USEFUL AS INHIBITORS OF β-SECRETASE (BACE)

The present invention is directed to novel 2-amino-3, 4-dihydro-quinazoline derivatives, pharmaceutical compositions containing them and their use in the treatment of Alzheimer's disease (AD) and related disorders. The compounds of the invention are inhibitors of P-secretase, also known as n-site cleaving enzyme and BACE.

NOVEL 2-AMINO-QUINAZOLINE DERIVATIVES USEFUL AS INHIBITORS OF β-SECRETASE (BACE)

The present invention is directed to novel 2-amino-3,4-dihydro-quinazoline derivatives, pharmaceutical compositions containing them and their use in the treatment of Alzheimer’s disease (AD) and related disorders. The compounds of the invention are inhibitors of β-secretase, also known as β-site cleaving enzyme and BACE.

TiCl4 induced N-methyleneamine equivalents: A new route to aminoacetonitriles

TiCl4 induced N-methyleneamine equivalents from hexahydro-1,3,5-triazines or N-(methoxymethyl)amines were reacted with trimethylsilyl cyanide to give aminoacetonitriles in 40-90% yield.

Reactions of Benzotriazole with Formaldehyde and Aliphatic Primary Amines: Selective Formation of 1:1:1, of 2:2:1, and of 2:3:2 Adducts and a Study of their Reactions with Nucleophiles

Benzotriazole (BtH) reacts easily with aliphatic primary amines and formaldehyde in aqueous media to give one or more of three types of product: (i) (BtCCH2)2NR (5), (ii) (BtCH2NR)2CH2 (6), and/or (iii) BtCH2NHR (7).The product formed depends on the molar

OXYDATION OF SECONDARY AMINES TO α-CYANOAMINES

The dehydrogenation of secondary amines with phenylseleninic anhydride or acid under mild conditions in the presence of either sodium cyanide or trimethylsilylcyanide gives good yields of α-cyanoamines.These compounds can be regarded as protected imines, or as a source of α-amino-acids.