1074-58-4Relevant articles and documents
Heterocycle Syntheses with Anionic N-Heterocyclic Carbenes: Ring Transformations of Sydnone Imine Anions
Freese, Tyll,Lücke, Ana-Luiza,Namyslo, Jan C.,Nieger, Martin,Schmidt, Andreas
, p. 1646 - 1654 (2018)
Sydnone imines were deprotonated at the C4 position to give lithium-stabilized anions, which proved to be stable for several months in solution. These anions are elements of the intersection of the substance classes of N-heterocyclic carbenes and mesomeric betaines. They can be formulated as anionic N-heterocyclic carbenes. The negative charge translates into high-field shifts of the 13C NMR resonance frequencies of C4 in comparison to other NHCs. Similar to the chemistry of N-heterocyclic carbenes, reactions with isocyanates and isothiocyanates gave 4-(N-carbamoyl)-benzoylsydnone imines in trapping reactions. As a result of ring transformations involving the characteristic π-architecture of the mesoionic framework, imidazolidine-2,4-dithiones, imidazolin-2,4-diones and 1,2,4-triazol-5-ones were formed depending on the substitution pattern of the starting materials and the reaction conditions.
REGULATORS FOR CONTROLLING LINEAR AND PSEUDO-RING EXPANSION POLYMERIZATION OF VINYL MONOMERS
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Page/Page column 33, (2017/07/01)
The invention concerns new regulator compounds for a novel polymerization process for vinyl monomers, which yields polymers with improved control over composition and nearly full to full conservation of architectural integrity up to high conversion. The regulator compounds are defined by according to anyone of the Formulas (1A), (1B), (1C), (1D), (1E), (1F), (1G), (1H) and (1I), wherein R1 stands for an optionally substituted secondary or tertiary alkyl or secondary or tertiary aralkyl; Z1 stands for -CN or a carboxylic acid ester of formula C(O)OR21; Z2 may be chosen from the group of -CN, carboxylic acid, salts of carboxylic acids, carboxylic acid ester, carboxylic acid amides, (hetero)aryl, alkenyl and halogen; R2, R3, R4 and R5 are each independently chosen from the group of H, alkyl, aralkyl, (hetero)aryl, -CN and carboxylic acid ester of formula C(O)OR22; R7 stands for a primary alkyl or primary aralkyl, -CN or hydrogen; Y stands for a bridging group and n is 2, 3, 4, 5 or 6; in case R1 stands for tertiary alkyl or tertiary aralkyl, R6 stands for a primary alkyl or primary aralkyl, -CN or a carboxylic acid ester of formula C(O)OR26; in case R1 stands for a secondary alkyl or secondary aralkyl, R6 stands for a primary or secondary alkyl or primary or secondary aralkyl, -CN, a carboxylic acid ester of formula C(O)OR26 or a phosphonic acid ester of formula P(O)(OR27)2, a (hetero)aryl or an alkenyl; R21, R22, R26 and R27 each independently stand for alkyl or aralkyi having from 1-30 carbon atoms, optionally containing heteroatoms.
NOVEL 2-AMINO-QUINAZOLINE DERIVATIVES USEFUL AS INHIBITORS OF β-SECRETASE (BACE)
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Page/Page column 305, (2010/10/20)
The present invention is directed to novel 2-amino-3,4-dihydro-quinazoline derivatives, pharmaceutical compositions containing them and their use in the treatment of Alzheimer’s disease (AD) and related disorders. The compounds of the invention are inhibitors of β-secretase, also known as β-site cleaving enzyme and BACE.
