2801-13-0

Basic information

• Product Name: 2,2'-Dithiobis[4,5-dihydro-thiazole]
• Synonyms: 2,2'-Dithiobis[4,5-dihydro-thiazole];2,2'-Dithiobis-2-thiazoline
• CAS NO: 2801-13-0
• Molecular Formula: C₆H₈N₂S₄
• Molecular Weight: 236.40112
• Product Categories: chemical additive;pharmaceutical intermediate
• Mol File: 2801-13-0.mol

Chemical Properties

• Melting Point: 120℃
• Appearance: /
• Density: 1.69
• CAS DataBase Reference: 2,2'-Dithiobis[4,5-dihydro-thiazole](CAS DataBase Reference)
• NIST Chemistry Reference: 2,2'-Dithiobis[4,5-dihydro-thiazole](2801-13-0)
• EPA Substance Registry System: 2,2'-Dithiobis[4,5-dihydro-thiazole](2801-13-0)

Safety Data

• Hazardous Substances Data: 2801-13-0(Hazardous Substances Data)

Usage

Uses

thiazolidin e thione pharmaceutical intermediate

Upstream product

• 595-49-3 2,2-dinitropropane 
• 71591-75-8 sodium 2-mercaptothiazolinate 
• 96-53-7 2-mercaptothiazoline 
• 134469-06-0 thiazolidine-2-thione 

Downstream Products

• 96-53-7 2-mercaptothiazoline 

Relevant articles and documents

A CONTROLLED STEPWISE OXIDATION OF ETHYL 2-OXOTHIAZOLIDINE-4-CARBOXYLATE TO THE CORRESPONDING 2-HYDROXYTHIAZOLE

Methyl 2-hydroxythiazole-4-carboxylate was obtained via a controlled stepwise oxidative procedure from the corresponding 2-oxothiazolidine.A series of intermediates have been isolated and characterized, supporting the ionic and radical mechanisms already proposed in the literature.

The Synthesis and Spontaneous Resolution of 2-(2-Thioxothiazolidin-3-yl)thiazole

A single crystalline enantiomer of 2-(2-thioxothiazolidin-3-yl)thiazole 5 has been isolated as the major product of the pyrolysis of 3-(2-thiazolin-2-yl)thiazolidine-2-thione 3 (n = 1); the latter isolated as the sole product of the reaction between thiazolidine-2-thione 2 (n = 1) and diethyl azodicarboxylate (DEAD) in benzene.

SYNTHESIS OF NEW THIOSULFONATES AND DISULFIDES FROM SULFONYL CHLORIDES AND THIOLS

Aromatic thiols were converted into thiosulfonates or disulfides, under very mild conditions, with fair to excellent yields, by using sulfonyl chloride as oxydant reagent.

Radical-Nucleophilic Substitution (SRN1) Reactions. Part 2. Preparation and Reactions of α-Nitrosulphides

A range of α-nitrosulphides have been prepared by oxidative addition of thiolate anion to the anion of 2-nitropropane, SN2 attack of the anion of 2-nitropropane on symmetrical disulphides, and SRN1 reaction of 2-substituted-2-nitropropanes with thiolate anions.The α-nitrosulphides undergo SRN1 substitution with the anion of 2-nitropropane, and SRN1 substitution or redox reactions with thiolate anions.The electron spin resonance (e.s.r.) spectrum of the radical-anion of 1-methyl-1-nitroethyl pyrimidin-2-yl sulphide has been observed.

Acid-catalysed Rearrangement of Bis-5,6-Dihydro-4H-1,3-thiazin-2-yl and Other Disulphides and Related Reactions

Some dithiocarbamates, thiocarbamates, and thiourea derivatives have been oxidised to the disulphides 1X(R2N=)C>2S2 with iodine.In the presence of trifluoroacetic acid, these lost sulphur giving the thiocarbonyl derivatives R1X(R2N=)C-N(R2)CSR1 (R1, R2, X =3, S; 2, S; Me, Me, S; Et, PhCH2, O; 5α-cholestan-3β-yl, Et, O; and Me, Ph, NMe).These rearrangements were most plausibly intramolecular, but proceeded by varying extents of intermolecular scrambling.