280117-50-2

Upstream product

• 123-75-1 pyrrolidine 
• 280120-00-5 6-(2'-bromomethyl-3-fluoro-biphenyl-4-yl)-1-(4-methoxy-phenyl)-7-oxo-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidine-3-carboxylic acid ethyl ester 
• 51337-35-0 cyano-(4-methoxy-phenylhydrazono)-acetic acid ethyl ester 
• 105-56-6 ethyl 2-cyanoacetate 
• 104-94-9 4-methoxy-aniline 
• 280117-49-9 6-(3-fluoro-2'-hydroxymethyl-biphenyl-4-yl)-1-(4-methoxy-phenyl)-7-oxo-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidine-3-carboxylic acid ethyl ester 
• 903876-92-6 6-(3-fluoro-2'-formyl-biphenyl-4-yl)-1-(4-methoxy-phenyl)-7-oxo-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidine-3-carboxylic acid ethyl ester 
• 903876-83-5 4-azido-5-(4-bromo-2-fluoro-phenylcarbamoyl)-1-(4-methoxy-phenyl)-1H-pyrazole-3-carboxylic acid ethyl ester 
• 903876-86-8 4-amino-5-(4-bromo-2-fluoro-phenylcarbamoyl)-1-(4-methoxy-phenyl)-1H-pyrazole-3-carboxylic acid ethyl ester 
• 903876-90-4 6-(4-bromo-2-fluoro-phenyl)-1-(4-methoxy-phenyl)-7-oxo-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidine-3-carboxylic acid ethyl ester 
• 280119-63-3 (1-[4-Methoxyphenyl]-3-(ethoxycarbonyl)-4-azido)pyrazole-5-carboxylic acid 
• 280119-62-2 3-ethyl-5-methyl (1-[4-Methoxyphenyl]-4-azido)pyrazole-3,5-dicarboxylate 
• 280119-61-1 3-Ethyl-5-methyl (1-[4-Methoxyphenyl]-4-amino)pyrazole-3,5-dicarboxylate 

Relevant academic research and scientific papers

Preparation of 1-(4-methoxyphenyl)-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-ones as potent, selective and bioavailable inhibitors of coagulation factor Xa

Previously, potent factor Xa inhibitors were described based on a pyrazole core. Modifications of the pyrazole core have provided additional novel, highly potent factor Xa inhibitors. This manuscript will describe the synthesis and biological activity of