28045-71-8

Upstream product

• 41489-76-3 methyl-5-formyl-2-hydroxybenzoate 
• 78515-16-9 methyl 5-formyl-2-methoxybenzoate 
• 18414-58-9 diphenylmethylsilanecarboxylic acid 
• 40757-09-3 methyl 2-methoxy-5-iodobenzoate 
• 7664-93-9 sulfuric acid 
• 2206-43-1 4-methoxyisophthalic acid 

Downstream Products

• 911281-96-4 methyl 5-carbamoyl-2-methoxybenzoate 
• 74121-10-1 4-methoxy-4-methoxycarbonylbenzoyl chloride 

Relevant academic research and scientific papers

Amide compound and pharmaceutical composition containing same and preparation method of amide compound and application of amide compound or pharmaceutical composition

The invention relates to an amide compound of a formula (I) shown in the description, a pharmaceutical composition containing with the same, a preparation method of the amide compound and applicationof the amide compound or the pharmaceutical composition, and specifically, the amide compound or the pharmaceutical composition can be used to prevent or treat retinoic acid receptor related orphan nuclear receptor gamma (ROR[gamma]) mediated diseases or symptoms.

Palladium-catalyzed synthesis of aromatic carboxylic acids with silacarboxylic acids

Aryl iodides and bromides were easily converted to their corresponding aromatic carboxylic acids via a Pd-catalyzed carbonylation reaction using silacarboxylic acids as an in situ source of carbon monoxide. The reaction conditions were compatible with a wide range of functional groups, and with the aryl iodides, the carbonylation was complete within minutes. The method was adapted to the double and selective isotope labeling of tamibarotene.

Compound for the treatment of atherosclerotic-thrombotic pathological conditions

4-Methoxy-N1-(4-trans-nitrooxycyclohexyl)-N3-(3-pyridinylmethyl)-1,3-benzenedicarboxamide and acid addition salts thereof with pharmaceutically acceptable organic and inorganic acids, and a pharmaceutical composition containing the same, for the treatment of vascular diseases involving atherosclerotic-thrombotic conditions and of other pathological conditions as shown in the description.

"Compound for the treatment of atherosclerotic-thrombotic pathological conditions"

4-Methoxy-N1-(4-trans-nitrooxycyclohexyl)-N3-(3-pyridinylmethyl)-1,3-benzenedicarboxamide of following formula 1: and acid addition salts thereof with pharmaceutically acceptable organic and inorganic acids, and a pharmaceutical composition containing the same, for the treatment of vascular diseases involving atherosclerotic-thrombotic conditions and of other pathological conditions as shown in the description.