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2206-43-1

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2206-43-1 Usage

Chemical Properties

White tooff-white powder

General Description

4-Methoxyisophthalic acid can be prepared by employing the following as a starting material:its dimethyl analogp-cresol4-methoxy-m-xylene3-methyl-4-methoxybenzyl chloride

Check Digit Verification of cas no

The CAS Registry Mumber 2206-43-1 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,2,0 and 6 respectively; the second part has 2 digits, 4 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 2206-43:
(6*2)+(5*2)+(4*0)+(3*6)+(2*4)+(1*3)=51
51 % 10 = 1
So 2206-43-1 is a valid CAS Registry Number.
InChI:InChI=1/C9H8O5/c1-14-7-3-2-5(8(10)11)4-6(7)9(12)13/h2-4H,1H3,(H,10,11)(H,12,13)

2206-43-1 Well-known Company Product Price

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  • Sigma-Aldrich

  • (P1645005)  PicotamideimpurityA  European Pharmacopoeia (EP) Reference Standard

  • 2206-43-1

  • P1645005

  • 1,880.19CNY

  • Detail

2206-43-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-methoxybenzene-1,3-dicarboxylic acid

1.2 Other means of identification

Product number -
Other names 4-Methoxy-isophthalsaeure

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:2206-43-1 SDS

2206-43-1Relevant articles and documents

Rao,Row

, p. 981,983 (1960)

Preparation method of picotamide

-

Paragraph 0027; 0034-0035, (2021/01/25)

The invention provides a method for preparing picotamide, which comprises the following steps: taking dimethyl 4-hydroxyl isophthalate as a raw material, carrying out methyl etherification reaction toobtain dimethyl 4-methoxy isophthalate; then, carrying out hydrolysis reaction to obtain 4-methoxy isophthalic acid; and finally, carrying out amidation reaction to obtain picotamide. Compared with atraditional method, the preparation method has the advantages of short synthesis steps, simplicity and convenience in operation, high reaction speed, high yield and the like. Besides, the raw materials required by the method are extracted from waste residues generated in industrial production, the extraction method is simple, the resource utilization rate is increased, the environmental pollutionis reduced, the production cost is reduced, and the method is suitable for large-scale industrial production.

Design, synthesis and biological evaluation of 4-methoxy diaryl isophthalates as antiplatelet agents

Xiu-jie, Liu,Chao-qing, Wang,Jie, Meng,xin-xin, Shi,ya-nan, Yan,Xu-guang, Liu

, p. 488 - 496 (2017/10/07)

A series of 4-methoxy diphenyl isophthalates, which are the isosturctural analogs of picotamide, were designed and synthesized using the concept of isosterism. The structures of these new analogs were characterized by all means of spectroscopy, including 1H NMR, 13C NMR, and MS spectra. In vitro antiplatelet aggregation activities of these compounds were investigated by using Born’s test method. Among the 19 compounds tested for both ADP and collagen inducers, six of them (P216–P219 and P220–P221) were found to exhibit higher activity in vitro antiplatelet aggregation than Picotamide. In particular, the compound P220 bearing a nitrooxyl group showed the highest acitivity 72.1% (induced by collagen) and 72.5% (induced by ADP), with IC50 values of 0.30 μM/L induced by ADP (1.3 μM/L) and LD50 CloseSPigtSPi 2500 mg/kg, could have dual mechanism of action. Evaluation of cytotoxic activity of the compounds against L929 cell line revealed that none of the compounds have significant cytotoxicity. Through the careful analysis of in vitro activity data, the SAR of these compounds was preliminarily deduced. The results of this study showed that 4-methoxy diaryl isophthalates derivatives are potential to become an antiplatelet aggregation agents.

New synthesis of 4-methoxyisophthalic acid

Liu,Yan,Wang,Li,Liu

, p. 459 - 461 (2017/05/09)

A new synthetic route to 4-methoxyisophthalic acid, the key intermediate in the synthesis of Picotamide, is reported. The new protocol starts from commercially available and cheap 4-methylphenol and includes four steps: esterification, Fries rearrangement, methylation, and oxidation; the overall yield is 49%. Unlike the traditional Blanc chloromethylation/oxidation scheme, the proposed procedure avoids using volatile and corrosive hydrochloric acid.

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