28047-05-4

Basic information

• Product Name: AC-TYR(ME)-OH
• Synonyms: AC-PHE(4-OME)-OH;AC-TYR(ME)-OH;ACETYL-O-METHYL-L-TYROSINE;N-O-di-methyl-L-tyrosine;L-TYROSINE, N-ACETYL-O-METHYL-;(S)-2-acetamido-3-(4-methoxyphenyl)propanoic acid;N-Ac-Tyr(Me)-OH;REF DUPL: N-Ac-Tyr(Me)-OH
• CAS NO: 28047-05-4
• Molecular Formula: C₁₂H₁₅NO₄
• Molecular Weight: 237.25
• Mol File: 28047-05-4.mol
• Article Data: 21

Chemical Properties

• Melting Point: 150-151 °C
• Boiling Point: 487.5±40.0 °C(Predicted)
• Appearance: /
• Density: 1.206±0.06 g/cm3(Predicted)
• PKA: 3.17±0.10(Predicted)
• CAS DataBase Reference: AC-TYR(ME)-OH(CAS DataBase Reference)
• NIST Chemistry Reference: AC-TYR(ME)-OH(28047-05-4)
• EPA Substance Registry System: AC-TYR(ME)-OH(28047-05-4)

Safety Data

• Hazardous Substances Data: 28047-05-4(Hazardous Substances Data)

Usage

General Description

AC-TYR(ME) OH, also known as acetylated tyrosine methyl ester, is a chemical compound derived from the amino acid tyrosine. The process of acetylation and methylation makes it distinct from regular tyrosine, resulting in different properties and functions. It is a synthetic product and not naturally occurring. It is commonly used in various kinds of research, particularly in the area of biochemistry and molecular biology. It is crucial for scientists working in these areas who are studying protein function and structure, gene expression, and enzymatic activity. Its exact effects can vary significantly depending on the context in which it is used.

Upstream product

• 73549-09-4 (Z)-2-acetamido-3-(4-methoxyphenyl)-2-propenoic acid 
• 556-02-5 ?Tyr 
• 6230-11-1 O-Methyltyrosine 
• 108-24-7 acetic anhydride 
• 71198-72-6 4-[(4-methoxyphenyl)methylene]-2-methyl-5(4H)-oxazolone 
• 68280-85-3 2-acetamido-3-(4-methoxyphenyl)-2-propenoic acid 
• 67-56-1 methanol 
• 71989-38-3 Fmoc-Tyr(tBu)-OH 
• 60-18-4 L-tyrosine 
• 17355-24-7 (S)-N-acetyl-3-(4-methoxyphenyl)alanine methyl ester 
• 123-11-5 4-methoxy-benzaldehyde 

Downstream Products

• 17355-24-7 (S)-N-acetyl-3-(4-methoxyphenyl)alanine methyl ester 
• 35061-31-5 (S)-ethyl 2-acetamido-3-(4-methoxyphenyl)propanoate 
• 1570061-42-5 Ac-L-Tyr(Me)-L-Ala-NH₂ 
• 1570061-44-7 Ac-L-Tyr(Me)-D-Ala-NH₂ 
• 1570061-28-7 Ac-L-Tyr(Me)-L-Ala-OH 
• 1570061-31-2 Ac-L-Tyr(Me)-D-Ala-OH 
• 1570061-37-8 Ac-L-Tyr(Me)-D-Val-OH 
• 1570061-38-9 Ac-L-Tyr(Me)-D-Leu-OH 
• 1570061-55-0 Ac-L-Tyr(Me)-D-Ala-Gly-NH₂ 
• 1570061-54-9 Ac-L-Tyr(Me)-L-Ala-Gly-NH₂ 
• 1570061-47-0 C₁₈H₂₅N₃O₆ 
• 1570061-50-5 C₂₁H₃₀N₄O₇ 
• 1570061-52-7 C₂₄H₃₅N₅O₈ 
• 1570061-34-5 Ac-L-Tyr(Me)-L-Val-OH 

Relevant articles and documents

Mixed Anhydride Intermediates in the Reaction of 5(4H)-Oxazolones with Phosphate Esters and Nucleotides

5(4H)-Oxazolones can be formed through the activation of acylated α-amino acids or of peptide C termini. They constitute potentially activated intermediates in the abiotic chemistry of peptides that preceded the origin of life or early stages of biology and are capable of yielding mixed carboxylic-phosphoric anhydrides upon reaction with phosphate esters and nucleotides. Here, we present the results of a study aimed at investigating the chemistry that can be built through this interaction. As a matter of fact, the formation of mixed anhydrides with mononucleotides and nucleic acid models is shown to take place at positions involving a mono-substituted phosphate group at the 3’- or 5’-terminus but not at the internal phosphodiester linkages. In addition to the formation of mixed anhydrides, the subsequent intramolecular acyl or phosphoryl transfers taking place at the 3’-terminus are considered to be particularly relevant to the common prebiotic chemistry of α-amino acids and nucleotides.

Diastereoselectivity in prebiotically relevant 5(4H)-oxazolone-mediated peptide couplings

A stereochemical study of a potentially prebiotic peptide-forming reaction was carried out as the first part of a systems chemistry investigation of potential paths for symmetry breaking. Substantial diastereomeric excesses result from a fast epimerization of the 5(4H)-oxazolone intermediate in aqueous solution. The Royal Society of Chemistry.

Synthesis and application of peripherally alkyl-functionalized dendritic pyrphos ligands: Homogeneous-supported catalysts for enantioselective hydrogenation

A new series of dendritic ligands with a chiral diphosphine located at the focal point have been synthesized through coupling of (R,R)-3,4-bis(biphenylphosphino)pyrrolidine (pyrphos) with peripherally alkyl-functionalized benzoic acid dendrons. These ligands were employed in the Rh-catalyzed asymmetric hydrogenation of prochiral dehydroamino acids, exhibiting excellent catalytic activities and enantioselectivities. The second-generation dendritic catalyst could be recovered by simple liquid-liquid biphasic separation and reused four times without serious loss of its activity and selectivity.