2808-12-0Relevant academic research and scientific papers
Rhodium-Catalyzed Annelation of Benzoic Acids with α,β-Unsaturated Ketones with Cleavage of C?H, CO?OH, and C?C Bonds
Zhang, Guodong,Hu, Zhiyong,Belitz, Florian,Ou, Yang,Pirkl, Nico,Goo?en, Lukas J.
, p. 6435 - 6439 (2019/04/10)
In the presence of a [Cp*RhCl2]2 catalyst, the Lewis acid In(OTf)3, and the mild base Na2CO3, aromatic carboxylates and α,β-unsaturated ketones undergo a unique hydroarylation/Claisen/retro-Claisen pr
BENZOYL-PIPERIDINE DERIVATIVES AS DUAL MODULATORS OF THE 5-HT2A AND D3 RECEPTORS
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Page/Page column 16, (2009/03/07)
The present invention relates to compounds of formula (I) wherein R1 and A are as defined in the specification as dual modulators of the serotonin 5-HT2a and dopamine D3 receptors, their manufacture, pharmaceutical compositions containing them and their use as medicaments. Compounds of general formula (I) have high affinity for the dopamine D3 and serotonin (5-Hydroxytryptamine; 5-HT) 5-HT2A receptors and are effective in the treatment of psychotic disorders, as well as other diseases such as depression and anxiety, drug dependence, dementias and memory impairment.
An environmentally friendly procedure for Mukaiyama aldol and Mukaiyama-Michael reactions using a catalytic amount of DBU under solvent- and metal-free conditions
Shen, Zhi-Liang,Ji, Shun-Jun,Loh, Teck-Peng
, p. 507 - 508 (2007/10/03)
Mukaiyama aldol and Mukaiyama-Michael reactions can proceed smoothly in the presence of a catalytic amount of DBU (20% mmol), to afford the corresponding products in moderate to good yields. This solvent- and metal-free approach provides an environmentall
A versatile synthesis of bicyclo[2.2.2]octan-2-one derivatives
Schmoldt, Philip,Mattay, Jochen
, p. 1071 - 1078 (2007/10/03)
A novel sequence for the synthesis of substituted bicyclo[2.2.2]oct-5-en-2-one derivatives starting from substituted cyclohex-2-en-1-ones is presented. The Michael addition of malonic esters to an α,β-unsaturated ketone and an intramolecular aldol reactio
Highly regioselective addition of an ester enolate equivalent to α,β-unsaturated ketones: Selective formation of both isomers derived from 1,2- and 1,4-additions using α-stannyl ester with additives
Yasuda,Matsukawa,Okamoto,Sako,Kitahara,Baba
, p. 2149 - 2150 (2007/10/03)
The reaction of α-stannyl ester with α,β-unsaturated ketones in the presence of stannous chloride (SnCl2) and chlorosilanes (Me3SiCl or Me2SiCl2) gave 1,2- and 1,4-addition products, respectively.
A novel asymmetric synthesis of 2,5-dialkylpyrrolidines
Daley, Valerie,D'Angelo, Jean,Cave, Christian,Mahuteau, Jacqueline,Chiaroni, Angele,Riche, Claude
, p. 1657 - 1660 (2007/10/03)
ZnCl2-promoted cyclization of enamino ester 8 furnished a 1.5:1 mixture of pyrrolidines 9 and 10. NaBH4-reduction of this mixture gave cis and trans-2,5-dialkylpyrrolidines 12 and 13 in the ratio 2:1. The latter derivative was obtain
Tetracyclic pyrrole lactam derivatives
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, (2008/06/13)
Disclosed are the compounds of formula I STR1 wherein R and R1 -R3 independently represent hydrogen or lower alkyl, and m represents the integer 2 or 3; their methods of preparation; pharmaceutical compositions thereof, and their use
Addition-1,4 d'enethiolates lithies de dithioesters aux cetones ethyleniques
Berrada, Said,Metzner, Patrick,Rakotonirina, Rose
, p. 881 - 890 (2007/10/02)
Deprotonation of carboxylic dithioesters with LDA gives rise to thermally stable lithium thioenolates that have been submitted to the action of various enones under kinetic conditions.Selective carbon-1,4-addition has been observed.Lithium thioenolates ma
Convenient Synthesis of Jasmonoid Compounds from γ-(Trimethylsiloxy)butyronitrile
Matsuda, Isamu,Murata, Shizuaki,Izumi, Yusuke
, p. 237 - 240 (2007/10/02)
1,4-Dioxygenated compounds 4 are constructed by the addition of a Grignard reagent to γ-(trimethylsiloxy)nitriles 1,2, and 3 and subsequent hydrolysis.Oxidation of 4 with pyridinium chlorochromate or Jones reagent yields compounds 5 which are used to produce cyclopentenones 6.Methyl jasmonate and methyl dihydrojasmonate are made by the conjugate addition of silylated ketene acetal 9 to 6a and 6b, respectively, and subsequent protodesilylation. γ-Jasmolactone is also derived from 4a by oxidation with pyridinium dichromate in DMF followed by reduction with NaBH4 in ethanol.
