28103-25-5

Upstream product

• 15764-47-3 2-phenylimidazo(1,2-a)pyrimidine 
• 70-11-1 α-bromoacetophenone 
• 4937-87-5 N-hydroxy-2-oxo-2-phenylethanimidoyl chloride 

Downstream Products

• 42837-61-6 5-amino-3-benzoyl-1,2,4-oxadiazole 
• 89185-42-2 N-(2-pyrimidyl)-benzimidoyl cyanide 
• 89185-48-8 2-phenylimidazo[1,2-a]pyrimidin-3-ylamine 

Relevant academic research and scientific papers

Synthesis and antibacterial activity of some imidazo[1,2-a[pyrimidine derivatives

A series of 75 imidazo[1,2-a]pyrimidine derivatives were synthesized. The 'in vitro' antibacterial activity of these compounds and their corresponding α-bromoketones against a variety of gram (+), gram (-) bacteria and Mycobacterium species is reported. Some of the prepared derivatives exhibited potent antimicrobial activity.

Antifungal activity in vitro of some imidazopyrimidine derivatives

In regard to fungicidal activity of imidazole ring found in chemical compounds such as econazole, a series of 42 diversely substituted imidazopyrimidines was synthetized and examined for its antifungal activity in several species.

Convenient Synthesis of Fused Heterocycles from α-Ketohydroximoyl Chlorides and Heterocyclic Amines

Nitroso derivatives of imidazopyridine (11,13,14), imidazopyrimidine (15), imidazopyrazine (16), imidazopyrazole (17), and imidazo-1,2,4-triazole (19) were obtained in good yields from α-ketohydroximoyl chlorides 3 and 2-aminopyrazines (4-6), 2-aminopyrimidine (7), 2-aminopyrazine (8), 5-amino-3-phenylpyrazole (9), and 3-amino-2H-1,2,4-triazole (10), respectively.Under different conditions, the reaction of 3 with 3-amino-2H-1,2,4-triazole (10) and 2-aminopyrazine (8) afforded the noncyclized substitution products 18 and 22, respectively.The structures of the products were assigned and confirmed on the basis of their elemental analyses, spectral data, and alternate synthesis wherever possible.

Imidazoindole derivatives and pharmaceutical compositions comprising imidazoindole derivatives

Pharmaceutical composition for chelating excess iron in a mammal and facilitating the removal of excess iron from the mammalian body are disclosed which comprise as active ingredient an iron-chelating agent selected from the group consisting of 5H-pyrimid