15764-47-3Relevant articles and documents
Facile access to novel 3-acylimidazo[1,2-a]pyrimidines under microwave irradiation
Shaaban, Mohamed R.
, p. 1775 - 1783 (2013)
Treatment of mono-, bis- and tris(ω-bromoacetophenone) derivatives with N,N-dimethylformamidine derivative of 2-aminopyrimidine, afforded the novel 3-aroyl or heteroyl derivatives of imidazo[1,2-α]pyrimidine, bis(imidazo[1,2-α]pyrimidine) and tris(imidazo
Tandem [8 + 2] cycloaddition-[2 + 6 + 2] dehydrogenation reactions involving imidazo[1,2- a ]pyridines and imidazo[1,2- a ]pyrimidines
Aginagalde, Maialen,Vara, Yosu,Arrieta, Ana,Zangi, Ronen,Cebolla, Vicente L.,Delgado-Camon, Arantzazu,Cossio, Fernando P.
, p. 2776 - 2784 (2010)
The reaction between benzynes and imidazo[1,2-a]pyridines (pyrimidines) to form benzo[a]imidazo[5,1,2-cd]indolizines and 2,3,9c-triazocyclopenta[j,k] fluorenes has been studied computationally and experimentally. It is found that these reactions take plac
Hypervalent Iodine in Synthesis 93. A Facile Synthesis of 2-Substituted Imidazo[1,2-a]pyrimidines by Cyclocondensation of Alkynyl(phenyl)iodonium Salts and 2-Aminopyrimidine
Liu, Zhi,Chen, Zhen-Chu,Zheng, Qin-Guo
, p. 909 - 911 (2003)
Simple stirring of a mixture of the alkynyl(phenyl)iodonium salts 1 with 2-aminopyrimidine 2 in chloroform under reflux for two hours in the presence of K2CO3 gave, after workup, the 2-substituted imidazo[1,2-a]pyrimidines 3 in moderate to good yields. A possible mechanism for the formation of 3 involves the intramolecular cyclization of the intermediate alkylidenecarbene 6.
Metal complex and application thereof
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Paragraph 0159-0163, (2021/08/06)
The invention relates to a metal complex and application thereof, the metal complex is a metal complex electrophosphorescent luminescent material with a pyrimidine fused ring structure, and is a series of metal complexes obtained by taking modified pyrimi
Synthesis and anti-inflammatory activity of 1,2-3-substituted 2a1,4,5-triazacyclopenta[cd]indene derivatives
Sanivarapu, Sumalatha,Vaddiraju, Namratha,Velide, Lakshmi
, p. 1461 - 1470 (2019/07/05)
The present study reports the synthesis of 1,2-3-substituted-2a1,4,5-triazacyclopenta[cd]indene derivatives. The synthetic methodology includes some of the prominent reaction steps as specified in sequence (i) Bromination of acetophenones (ii) Condensation of 2-bromo-1-(substituted phenyl) ethanone derivatives with 2-aminopyrimidine, and (iii) Coupling of imidazo[1,2-a]pyrimidine derivatives with 1,2-diaryl/diaklylethynes. The structures of the newly synthesized derivatives have been determined by 1H NMR, 13C NMR, LC-MS, and IR spectral analysis. Furthermore, these derivatives were screened for their preliminary anti-inflammatory activities using Carrageenan induced paw edema test method. These promising screening results suggested a huge potential for the molecular diversity from present compounds that can be inflated to better lead candidates.
Cobalt-Catalyzed Aerobic Cross-Dehydrogenative Coupling of C-H and Thiols in Water for C-S Formation
Huang, Xin,Chen, Yongqi,Zhen, Shan,Song, Lijuan,Gao, Mingqi,Zhang, Panke,Li, Heng,Yuan, Bingxin,Yang, Guanyu
, p. 7331 - 7340 (2018/07/29)
Organosulfides have great significance and value in synthetic and biological chemistry. To establish a versatile and green methodology for C-S bond generation, we successfully developed a new aerobic cross-dehydrogenative coupling of C-H and S-H to synthe
Iron-Catalyzed Dehydrogenative sp3-sp2 Coupling via Direct Oxidative C-H Activation of Acetonitrile
Su, Huimin,Wang, Luyao,Rao, Honghua,Xu, Hao
supporting information, p. 2226 - 2229 (2017/05/12)
An iron-catalyzed dehydrogenative sp3-sp2 coupling of acetonitrile and 2-arylimidazo[1,2-a]pyridine has been realized, which can serve as a novel approach toward heteroarylacetonitriles. The merit of this strategy is illustrated by the breadth of functional groups tolerated in the transformation and the fast access to pharmaceuticals (such as zolpidem) directly from the heteroarylacetonitriles.
Easy and efficient selenocyanation of imidazoheterocycles using triselenodicyanide
Redon, Sébastien,Obah Kosso, Anne Roly,Broggi, Julie,Vanelle, Patrice
supporting information, p. 2771 - 2773 (2017/06/23)
The regioselective selenocyanation of imidazoheterocycles using triselenodicyanide at room temperature is reported. The electrophilic aromatic substitution of a broad range of substrates is promoted by the triselenodicyanide obtained by oxidative coupling
Novel Combretastatin-2-aminoimidazole Analogues as Potent Tubulin Assembly Inhibitors: Exploration of Unique Pharmacophoric Impact of Bridging Skeleton and Aryl Moiety
Chaudhary, Vikas,Venghateri, Jubina B.,Dhaked, Hemendra P. S.,Bhoyar, Anil S.,Guchhait, Sankar K.,Panda, Dulal
, p. 3439 - 3451 (2016/05/19)
Combretastatin A-4 (CA-4) in phosphate and serine pro-drug forms is under phase II clinical trials. With our interest of discovering CA-4 inspired new chemical entities, a novel series of 4,5-diaryl-2-aminoimidazole analogues of the compound was designed
Highly Efficient and Practical Thiocyanation of Imidazopyridines Using an N-Chlorosuccinimide/NaSCN Combination
Zhang, Hailei,Wei, Qian,Wei, Shiqiang,Qu, Jingping,Wang, Baomin
, p. 3373 - 3379 (2016/07/23)
A direct C–H thiocyanation of imidazo[1,2-a]pyridines, and a practical sequential one-pot condensation/C–H thiocyanation process, using a combination of N-chlorosuccinimide/NaSCN for the synthesis of 3-thiocyanatoimidazo[1,2-a]pyridines have been develope
