281192-96-9Relevant academic research and scientific papers
AlCl3/PCC-SiO2-promoted oxidation of azaindoles and indoles
Sriram, Rekulapally,Sesha Sai Pavan Kumar, Chebolu Naga,Raghunandan, Nerella,Ramesh, Vadla,Sarangapani, Manda,Rao, Vaidya Jayathirtha
experimental part, p. 3419 - 3428 (2012/09/22)
A simple and efficient method is described for the oxidation of 7-azaindoles and indoles to 7-azaisatins and isatins using pyridinium chlorochromate-silica gel (PCC-SiO2) with the aid of Lewis acid catalyst aluminium chloride (AlCl3) in dichloroethane. Simplicity of the reaction conditions, easy workup procedure, and good yields are the key features of this protocol.
Indium(III) chloride/2-iodoxybenzoic acid: A novel reagent system for the conversion of indoles into isatins
Yadav,Subba Reddy,Reddy, Ch. Suresh,Krishna
, p. 693 - 696 (2007/12/29)
Indoles and azaindoles undergo smooth oxidation with 2-iodoxybenzoic acid (IBX) in the presence of indium(III) chloride at 80°C to afford the corresponding isatins in excellent yields. This method is very useful for the direct preparation of isatins from indoles. The reaction proceeds smoothly in aqueous media and the products are obtained in excellent yields. Georg Thieme Verlag Stuttgart.
A facile synthesis of 1-alkyl-7-azaisatins
Tatsugi, Jiro,Zhiwei, Tong,Amano, Tomohiro,Izawa, Yasuji
, p. 1145 - 1150 (2007/10/03)
1-Alkyl-7-azaisatins are synthesized from the reaction of 1-alkyl-7- azaindoles with bromine in dichloromethane and subsequent oxidation with N- bromosuccinimide - dimethyl sulfoxide reagent. 1-Alkyl-7-azaindoles are readily available in high yields from
