281195-24-2Relevant academic research and scientific papers
A novel, efficient, and recyclable biocatalyst for Michael addition reactions and its iron(iii) complex as promoter for alkyl oxidation reactions
Khalil, Khaled D.,Ibrahim, Enas I.,Al-Sagheer, Fakhreia A.
, p. 1410 - 1416 (2016/03/08)
Chitosan-g-poly(2-cyano-1-(pyridin-3-yl)allyl acrylate) (Cs-g-PCPA), having a grafting percentage (G%) of 64%, was prepared and was then subjected to complexation with iron(iii) (Cs-g-PCPA/Fe(iii)). The results of the catalytic studies demonstrated that Cs-g-PCPA serves as an efficient, recyclable and eco-friendly, basic catalyst for Michael addition reactions, which produce adducts in high yields under mild conditions. Moreover, a Cs-g-PCPA-supported iron(iii) complex was prepared and was then characterized by using FESEM, XRD, TGA, and XPS. In addition, the EDS plot of the Fe(iii) chelate confirms the presence of a relatively high amount (13%) of Fe(iii). The Cs-g-PCPA (G% = 64)-supported iron(iii) complex (Cs-g-PCPA/Fe(iii)) in the presence of H2O2 can be used to oxidize methyl pyridazinyl carbonitriles to form the corresponding fused furan derivatives efficiently. These polymeric catalysts are stable such that they can be recycled and reused more than five times without losing their catalytic activity.
THIENOPYRIDONE DERIVATIVES AS AMP-ACTIVATED PROTEIN KINASE (AMPK) ACTIVATORS
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, (2011/02/26)
The present invention relates to compounds of formula (I) wherein R1, R2 and R3 are as defined in claim 1, including pharmaceutical compositions thereof and for their use in the treatment and/or prevention of diseases and disorders modulated by AMP agonists. The invention is also directed to intermediates and to a method of preparation of compounds of formula (I).
THIENOPYRIDONE DERIVATIVES AS AMP-ACTIVATED PROTEIN KINASE (AMPK) ACTIVATORS
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Page/Page column 48-49, (2009/11/29)
The present invention relates to compounds of formula (I) wherein R1, R2 and R3 are as defined in claim 1, including pharmaceutical compositions thereof and for their use in the treatment and/or prevention of diseases and disorders modulated by AMP agonis
β-enaminonitriles in heterocyclic synthesis: Synthesis of new 1,4-dihydropyridine, pyrazolo[1,5-a]pyrimidine, aminothiophene and pyridine derivatives
Hafiz, Ibrahim S. A.
, p. 321 - 325 (2007/10/03)
Utility of 3-aminocinnamonitrile (1) in the synthesis of new 1,4-dihydropyridine, pyrazolo[1,5-a]pyrimidine, aminothiophene and pyridine derivatives is reported.
