60375-56-6

Basic information

• Product Name: 2-Propenenitrile, 3-amino-3-phenyl-, (E)-
• CAS NO: 60375-56-6
• Molecular Formula: C9H8N2
• Molecular Weight: 144.176
• Mol File: 60375-56-6.mol
• Article Data: 20

Chemical Properties

• CAS DataBase Reference: 2-Propenenitrile, 3-amino-3-phenyl-, (E)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propenenitrile, 3-amino-3-phenyl-, (E)-(60375-56-6)
• EPA Substance Registry System: 2-Propenenitrile, 3-amino-3-phenyl-, (E)-(60375-56-6)

Safety Data

• Hazardous Substances Data: 60375-56-6(Hazardous Substances Data)

Upstream product

• 614-16-4 Benzoylacetonitrile 
• 140-29-4 phenylacetonitrile 
• 75-05-8 acetonitrile 
• 536-74-3 phenylacetylene 
• 100-47-0 benzonitrile 
• 60-29-7 diethyl ether 
• 99749-00-5 lithioacetonitrile 
• 14904-36-0 cis-trans-3--cinnamonitril 
• 14904-42-8 cis-trans-3-Trimethylsilylamino-cinnamonitril 
• 3755-96-2 (2Z)-3-bromo-3-phenylprop-2-enenitrile 

Downstream Products

• 100784-53-0 6-hydroxy-2,4-diphenyl-nicotinonitrile 
• 33831-53-7 4-hydroxy-6-methyl-2-phenyl-nicotinonitrile 
• 452070-10-9 4-methyl-2-phenyl-quinoline-3-carbonitrile 
• 73013-67-9 2-phenylquinoline-3-carbonitrile 
• 1563-41-3 2-(α-amino-benzyliden)-5-oxo-hex-3-enenitrile 
• 853916-48-0 4-(2-methoxy-phenyl)-2,6-diphenyl-1,4-dihydro-pyridine-3,5-dicarbonitrile 
• 69316-11-6 α-hydroximido-(2-benzoyl)acetonitrile 
• 39603-81-1 α-Cyano-β-amino-zimtsaeurechlorid 
• 23889-45-4 N-(toluene-4-sulfonyl)-3-amino-2-cyano-3-phenyl-thioacrylamide 
• 117266-82-7 4-cyano-3-hydroxy-3-methoxy-5-phenyl-1H-pyrrole-2-one 
• 117290-47-8 2,5-cyano-1,6-diimino-1,6-diphenyl-hexane-3,4-dione 
• 128421-54-5 3-(4-Methoxy-2,6-dimethyl-phenyl)-5-phenyl-isoxazole-4-carbonitrile 
• 128421-38-5 (Z)-2-[3-(4-Methoxy-2,6-dimethyl-phenyl)-[1,2,4]oxadiazol-5-yl]-1-phenyl-vinylamine 

Relevant articles and documents

Tetrasubstituted 1,3-Enynes by Gold-Catalyzed Direct C(sp2)-H Alkynylation of Acceptor-Substituted Enamines

A gold-catalyzed synthesis of tetrasubstituted 1,3-enynes from hypervalent iodine(III) reagents and activated alkenes is reported. This reaction involves an in situ formed alkynyl Au(III) species and a subsequent direct C(sp2)-H functionalization of alkenes, offering 26 enynes in 62-92% yield with excellent functional group tolerance.

Multi-component synthesis of 3-substituted indoles and their cyclisation to α-carbolines: Via I2-promoted intramolecular C2 oxidative amination/aromatisation at room temperature

Condensation of indoles, aldehydes and pyrazol-5-amine in the presence of ceric ammonium nitrate gives 3-substituted indoles. These then cyclise to α-carbolines at room temperature through I2-promoted intramolecular C2 amination and aromatisation in open air. A plausible mechanism is proposed based on some controlled experiments.

Tandem Thorpe Reaction/Palladium Catalyzed Asymmetric Allylic Alkylation: Access to Chiral β-enaminonitriles with Excellent Enantioselectivity

A new type of nucleophile, a 3-imino nitrile carbanion generated in situ by Thorpe reaction of acetonitrile with a base, was developed successfully and applied in a Pd-catalyzed asymmetric allylic alkylation with mono-substituted allyl reagents under Pd/S