28131-17-1

Basic information

• Product Name: 2-(4-bromophenyl)acrylic acid
• Synonyms: 2-(4-bromophenyl)acrylic acid
• CAS NO: 28131-17-1
• Molecular Weight: 227.057
• Mol File: 28131-17-1.mol
• Article Data: 22

Chemical Properties

• CAS DataBase Reference: 2-(4-bromophenyl)acrylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-bromophenyl)acrylic acid(28131-17-1)
• EPA Substance Registry System: 2-(4-bromophenyl)acrylic acid(28131-17-1)

Safety Data

• Hazardous Substances Data: 28131-17-1(Hazardous Substances Data)

Usage

Structure

Derivative of acrylic acid It is a modified version of acrylic acid, with a 4-bromophenyl group attached to the second carbon of the acrylic acid chain.

Bromophenyl group

4-bromophenyl The attached group in 2-(4-bromophenyl)acrylic acid is a phenyl ring with a bromine atom at the 4-position (the meta position).

Usage

Organic synthesis and pharmaceutical research This compound is commonly used as a building block in the development of various drugs and biologically active molecules.

Importance

Intermediate in production 2-(4-bromophenyl)acrylic acid is an important intermediate in the production of pharmaceuticals and other fine chemicals due to its unique structure and properties.

Applications

Scientific and industrial The compound has significant applications in both scientific research and industrial processes, contributing to the development of new drugs and chemical products.

Upstream product

• 331779-03-4 ethyl 2-(4-bromophenyl)propenoate 
• 124-38-9 carbon dioxide 
• 75230-51-2 4-bromoacetophenone tosylhydrazone 
• 64-18-6 formic acid 
• 766-96-1 4-bromo-1-ethynylbenzene 
• 201230-82-2 carbon monoxide 
• 1878-68-8 2-(4-bromophenyl)-acetic acid 
• 14062-25-0 Ethyl 4-bromophenylacetate 
• 18620-02-5 (4-bromophenyl)magnesium bromide 
• 20201-26-7 ethyl 4-bromophenylglyoxylate 
• 41841-16-1 (4-bromo-phenyl)-acetic acid methyl ester 

Downstream Products

• 1264519-70-1 (S)-3-tert-butyl 1-(phenanthren-9-yl) 1-(4-bromophenyl)cyclopent-3-ene-1,3-dicarboxylate 
• 1325755-34-7 C₁₄H₁₃BrN₂O 
• 1325755-51-8 tert-butyl (4S)-4-(4-bromophenyl)-4-[(3,5-dimethyl-1H-pyrazol-1-yl)carbonyl]cyclopent-1-ene-1-carboxylate 
• 41024-55-9 1-(4-bromophenyl)-2-(phenylsulfonyl)ethanone 
• 31377-97-6 1-(4-bromophenyl)-2-tosylethanone 
• 1439401-84-9 3-(4-bromophenyl)-1-methylquinolin-2(1H)-one 
• 1180670-65-8 1-(4'-bromophenyl)-4,4,4-trifluoro-1-butanone 
• 1180670-63-6 1-(4-bromophenyl)-5,5,5-trifluoropentan-1-one 
• 51765-77-6 4-(4-bromo-phenyl)-4-oxo-butyronitrile 

Relevant articles and documents

Free-Radical-Promoted Copper-Catalyzed Decarboxylative Alkylation of α,β-Unsaturated Carboxylic Acids with ICH2CF3 and Its Analogues

A novel and efficient free-radical-promoted copper-catalyzed decarboxylative alkylation of α,β-unsaturated carboxylic acids with ICH2CF3 and its analogues has been developed. This methodology provides a convenient access to the synthesis of allylic trifluoromethyl and β-CF3 ketone containing compounds as well as other biologically useful fluorinated molecules and materials.

Rh-Catalyzed Coupling of Acrylic/Benzoic Acids with α-Diazocarbonyl Compounds: An Alternative Route for α-Pyrones and Isocoumarins

A coupling of acrylic acids/benzoic acids with α-diazocarbonyl compounds has been realized by a combined catalytic system of rhodium catalyst and Zn(OAc)2 additive. The presence of Zn(OAc)2 obviously accelerates the C(sp2)

Synthesis of Cyclopentenones through Rhodium-Catalyzed C-H Annulation of Acrylic Acids with Formaldehyde and Malonates

An efficient rhodium-catalyzed protocol for the synthesis of cyclopentenones based on a three-component reaction of acrylic acids, formaldehyde, and malonates via vinylic C-H activation is reported. Exploratory studies showed that 5-alkylation of as-prepared cyclopentenones could be realized smoothly by the treatment of a variety of alkyl halides with a Na2CO3/MeOH solution. Excess formaldehyde and malonate led to a multicomponent reaction that afforded the multisubstituted cyclopentenones through a Michael addition.