77607-71-7

Upstream product

• 98-03-3 thiophene-2-carbaldehyde 
• 98-86-2 acetophenone 
• 109-77-3 malononitrile 
• 19433-17-1 (E)‐1‐phenylethan‐1‐one O‐acetyl oxime 
• 28162-32-5 2-(2-thienyl)-1-cyanoacrylonitrile 
• 2910-81-8 3-(2'-thienyl)acrylophenone 

Downstream Products

• 77607-79-5 2-Amino-6-phenyl-4-thiophen-2-yl-nicotinamide 

Relevant academic research and scientific papers

CuI@Al2O3 catalyzed synthesis of 2-aminonicotinonitrile derivatives under solvent free condition

A Green approach for the synthesis of 2-aminonicotinonitriles from oxime acetate as enamine precursor, aldehyde and malononitrile under neat condition without the use of additive in presence of CuI@Al2O3 nanocatalyst is reported. Wid

Synthesis of Some Polysubstituted Nicotinonitriles and Derived Pyrido[2,3-d]pyrimidines as in Vitro Cytotoxic and Antimicrobial Candidates

The synthesis of polysubstituted pyridines, in addition to some derived pyrido[2,3-d]pyrimidine ring systems supported with chemotherapeutically active functionalities, is described. They were evaluated for their in vitro cytotoxic effects against three d

Novel Bu4N+Br- catalyzed one-pot multi-component synthesis of 2-amino nicotinonitriles in aqueous medium

Abstract An efficient single-pot strategy for 2-amino nicotinonitrile derivatives 5 has been developed by multi-component reaction of arylaldehydes 1, methylketones 2, malononitrile 3, and ammonium acetate 4 using tetrabutyl ammonium bromide as catalyst in aqueous medium.

2-Amino-6-furan-2-yl-4-substituted nicotinonitriles as A2a adenosine receptor antagonists

A2A adenosine receptor antagonists usually have bi- or tricyclic N aromatic systems with varying substitution patterns to achieve desired receptor affinity and selectivity. Using a pharmacophore model designed by overlap of nonxanthine type of previously known A2A antagonists, we synthesized a new class of compounds having a 2-amino nicotinonitrile core moiety. From our data, we conclude that the presence of at least one furan group rather than phenyl is beneficial for high affinity on the A2A adenosine receptor. Compounds 39 (LUF6050) and 44 (LUF6080) of the series had Ki values of 1.4 and 1.0 nM, respectively, with reasonable selectivity toward the other adenosine receptor subtypes, A1, A 2B, and A3. The high affinity of 44 was corroborated in a cAMP second messenger assay, yielding subnanomolar potency for this compound.

Malononitriles & Cyanoesters : Part VI - Synthesis of New Biologically Active Cyanopyridines

3-(2'-Furyl)- and 3-(2'-thienyl)-acrylophenones (I) react with malononitrile in the presence of ammonium acetate to give 2-amino-3-cyano-4,6-disubstituted-pyridines (II).The latter are hydrolysed with alkali to give the corresponding nicotinamides (IV).Th

Malononitriles and Cyanoesters: Part VII- Diaryl- and Dithienylpropenones and -cyanopyridines and Their Molluscicidal Activity

2-Amino-3-cyano-4,6-disubstituted-pyridines (6) and 3-cyano-4,6-disubstituted-pyridin-2-ones (10) are obtained by reacting the corresponding propenones (1) with malononitrile and ethyl cyanoacetate, respectively, in the presence of ammonium acetate.The compounds (6) and (10) can be readily obtained by reacting the corresponding ylidene-malononitriles (8) and -cyanoesters (9) with the appropriate ketone.Molluscicidal activity of the compounds is also discussed.