39145-35-2

Upstream product

• 98-03-3 thiophene-2-carbaldehyde 
• 7357-70-2 Cyanothioacetamide 
• 28162-32-5 2-(2-thienyl)-1-cyanoacrylonitrile 
• 19172-47-5 Lawessons reagent 
• 95644-00-1 2-benzoyl-3-(2-thienyl)prop-2-enenitrile 

Downstream Products

• 129340-06-3 1-Thiophen-2-yl-3-thioxo-2,3,5,6,7,8-hexahydro-isoquinoline-4-carbonitrile 
• 82127-11-5 4-phenyl-6-(thiophen-2-yl)-2-thioxo-1,2-dihydropyridine-3-carbonitrile 
• 128342-36-9 6-(thiophen-2-yl)-2-thioxo-4-(p-tolyl)-1,2-dihydro-pyridine-3-carbonitrile 
• 128342-41-6 4-(4-methoxyphenyl)-6-(thiophen-2-yl)-2-thioxo-1,2-dihydropyridine-3-carbonitrile 
• 129226-99-9 6-(2-Amino-phenylsulfanyl)-4-thiophen-2-yl-2-thioxo-1,2-dihydro-pyridine-3,5-dicarbonitrile 
• 28162-32-5 2-(2-thienyl)-1-cyanoacrylonitrile 
• 160887-43-4 3-cyano-5-ethoxcarbonyl-6-methyl-4-(2'-thienyl)pyridin-2-(1H)-thione 
• 952720-99-9 C₂₆H₁₇N₃O₃S₂ 
• 952720-97-7 C₂₅H₁₄N₂O₂S₂ 

Relevant academic research and scientific papers

Multicomponent Synthesis and Molecular and Crystal Structure of New Derivatives of Partially Hydrogenated Quinolines

Abstract: The multicomponent condensation of aromatic aldehydes, cyanothioacetamide, 1-(cyclohex-1-en-1-yl)azepine, and α-halocarbonyl compounds was studied. As a result, new derivatives of partially hydrogenated quinolines were synthesized. The molecular and crystal structures of a number of the synthesized heterocycles were studied X-ray analysis.

Multicomponent synthesis of 2-(alkylsulfanyl)-4-[furan-2-yl-(or thiophen-2-yl)]-5,6,7,8-tetrahydroquinoline-3-carbonitriles

Abstract Substituted 2-(alkylsulfanyl)-4-[furan-2-yl(or thiophen-2-yl)]-5,6,7,8-tetrahydroquinoline-3-carbonitriles were synthesized by condensation of furfural or thiophene-2-carbaldehyde with 2-cyanoethanethioamide, 1-(cyclohex-1-en-1-yl)pyrrolidine, and alkyl halides. The structure of methyl 2-{[3-cyano-4-(thiophen-2-yl)-5,6,7,8-tetrahydroquinolin-2-yl]sulfanyl}acetate was determined by X-ray analysis.

Design and synthesis of pyrido[2,1- b ][1,3,5]thiadiazine library via uncatalyzed mannich-type reaction

This Research Article describes the synthesis of an over 700-member library of (8R/8S)-3-R-8-aryl-6-oxo-3,4,7,8-tetrahydro-2H,6H-pyrido[2,1-b][1,3,5]thiadiazin-9-carbonitriles by uncatalyzed Mannich-type reaction of N-methylmorpholinium (4R/4S)-4-aryl-3-cyano-6-oxo-1,4,5,6-tetrahydropyridin-2-thiolates with a set of primary amines and excessive HCHO. The scope and limitations of the reaction were studied. Starting thiolates were obtained in yields of 53-82% by multicomponent reaction of aromatic aldehydes, cyanothioacetamide, 2,2-dimethyl-1,3-dioxane-4,6-dione (Meldrum's acid), and N-methylmorpholine, followed by heterocyclization of the resulting Michael adducts.

Methods for treating Hepatitis C

In accordance with the present invention, compounds that can inhibit viral replication, preferably Hepatitis C Virus (HCV) replication, have been identified, and methods for their use provided. In one aspect of the invention, compounds useful in the treatment or prevention of a viral infection are provided. In another aspect of the invention, compounds useful in the treatment or prevention of HCV infection are provided.

Organophosphorus chemistry, 291. The action of 2,4-bis-(4-methoxyphenyl)-1,3,2,4-dithiaphosphetane-2,4-disulfide (Lawesson's reagent) on α, ss-unsaturated nitriles

The reaction of 2,4-bis-(4-methoxyphenyl)-1,3,2,4-dithiaphosphetane-2,4-disulfide (Lawesson's reagent. LR, 1) with ylidenemalononitriles (5a-f) was studied. Partial hydrolysis of 5a-f followed by thiation with LR yields the respective thioamides 7a-f. Nuc

ACTIVATED NITRILES IN HETEROCYCLIC SYNTHESIS: A NEW SYNTHESIS OF 3-FURAN-2-YLIDENE- AND 3-THIOPHEN-2-YLIDENE-3,6-DIHYDROPYRIDINE DERIVATIVES

Synthesis of 3-furan-2-ylidene- and 3-thiophen-2-ylidene-3,6-dihydropyridine derivatives via the reaction of cyanothioacetamide with furan-2-ylidene and thiophen-2-ylidene derivatives of malononitrile, ethyl cyanoacetate and benzoylacetonitrile.