39145-35-2Relevant articles and documents
Multicomponent Synthesis and Molecular and Crystal Structure of New Derivatives of Partially Hydrogenated Quinolines
Dorovatovskii, P. V.,Dyachenko, I. V.,Dyachenko, V. D.,Khrustalev, V. N.,Nenaidenko, V. G.
, p. 1824 - 1833 (2021/12/22)
Abstract: The multicomponent condensation of aromatic aldehydes, cyanothioacetamide, 1-(cyclohex-1-en-1-yl)azepine, and α-halocarbonyl compounds was studied. As a result, new derivatives of partially hydrogenated quinolines were synthesized. The molecular and crystal structures of a number of the synthesized heterocycles were studied X-ray analysis.
Multicomponent synthesis of 2-(alkylsulfanyl)-4-[furan-2-yl-(or thiophen-2-yl)]-5,6,7,8-tetrahydroquinoline-3-carbonitriles
Dyachenko,Nesterov,Dyachenko,Chernykh
, p. 864 - 868 (2015/08/06)
Abstract Substituted 2-(alkylsulfanyl)-4-[furan-2-yl(or thiophen-2-yl)]-5,6,7,8-tetrahydroquinoline-3-carbonitriles were synthesized by condensation of furfural or thiophene-2-carbaldehyde with 2-cyanoethanethioamide, 1-(cyclohex-1-en-1-yl)pyrrolidine, and alkyl halides. The structure of methyl 2-{[3-cyano-4-(thiophen-2-yl)-5,6,7,8-tetrahydroquinolin-2-yl]sulfanyl}acetate was determined by X-ray analysis.
Design and synthesis of pyrido[2,1- b ][1,3,5]thiadiazine library via uncatalyzed mannich-type reaction
Dotsenko, Victor V.,Frolov, Konstantin A.,Pekhtereva, Tatyana M.,Papaianina, Olena S.,Suykov, Sergey Yu.,Krivokolysko, Sergey G.
, p. 543 - 550 (2014/12/10)
This Research Article describes the synthesis of an over 700-member library of (8R/8S)-3-R-8-aryl-6-oxo-3,4,7,8-tetrahydro-2H,6H-pyrido[2,1-b][1,3,5]thiadiazin-9-carbonitriles by uncatalyzed Mannich-type reaction of N-methylmorpholinium (4R/4S)-4-aryl-3-cyano-6-oxo-1,4,5,6-tetrahydropyridin-2-thiolates with a set of primary amines and excessive HCHO. The scope and limitations of the reaction were studied. Starting thiolates were obtained in yields of 53-82% by multicomponent reaction of aromatic aldehydes, cyanothioacetamide, 2,2-dimethyl-1,3-dioxane-4,6-dione (Meldrum's acid), and N-methylmorpholine, followed by heterocyclization of the resulting Michael adducts.
Methods for treating Hepatitis C
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Page/Page column 119, (2010/02/15)
In accordance with the present invention, compounds that can inhibit viral replication, preferably Hepatitis C Virus (HCV) replication, have been identified, and methods for their use provided. In one aspect of the invention, compounds useful in the treatment or prevention of a viral infection are provided. In another aspect of the invention, compounds useful in the treatment or prevention of HCV infection are provided.
Organophosphorus chemistry, 291. The action of 2,4-bis-(4-methoxyphenyl)-1,3,2,4-dithiaphosphetane-2,4-disulfide (Lawesson's reagent) on α, ss-unsaturated nitriles
Khidre, Maha D.,Yakout, El-Sayed M.A.,Refat, Mohamed,Mahran
, p. 119 - 125 (2007/10/03)
The reaction of 2,4-bis-(4-methoxyphenyl)-1,3,2,4-dithiaphosphetane-2,4-disulfide (Lawesson's reagent. LR, 1) with ylidenemalononitriles (5a-f) was studied. Partial hydrolysis of 5a-f followed by thiation with LR yields the respective thioamides 7a-f. Nuc
ACTIVATED NITRILES IN HETEROCYCLIC SYNTHESIS: A NEW SYNTHESIS OF 3-FURAN-2-YLIDENE- AND 3-THIOPHEN-2-YLIDENE-3,6-DIHYDROPYRIDINE DERIVATIVES
Elgemeie, Galal Eldin Hamza,Hafez, Ebtisam Abdel Aziz,Nawar, Galal Abdel Moein,Elnagdi, Mohamed Hilmy
, p. 2829 - 2833 (2007/10/02)
Synthesis of 3-furan-2-ylidene- and 3-thiophen-2-ylidene-3,6-dihydropyridine derivatives via the reaction of cyanothioacetamide with furan-2-ylidene and thiophen-2-ylidene derivatives of malononitrile, ethyl cyanoacetate and benzoylacetonitrile.
