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Iopromide
Cas No: 73334-07-3
USD $ 650.0-690.0 / Kilogram 1 Kilogram 100 Metric Ton/Month Salus Nutra Inc Contact Supplier
Hot Selling Iopromide price 73334-07-3
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Corey Iopromide
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USD $ 1.0-1.0 / Kilogram 1 Kilogram 100 Kilogram/Month Career Henan Chemical Co Contact Supplier
Iopromide Manufacturer/High quality/Best price/In stock
Cas No: 73334-07-3
USD $ 3.0-3.0 / Kilogram 1 Kilogram 1-100 Metric Ton/Month Dayang Chem (Hangzhou) Co.,Ltd. Contact Supplier
High purity Various Specifications Iopromide CAS:73334-07-3
Cas No: 73334-07-3
USD $ 100.0-500.0 / Gram 1 Gram 99999 Gram/Year Hangzhou Dingyan Chem Co., Ltd Contact Supplier
Iopromide
Cas No: 73334-07-3
USD $ 1000.0-1000.0 / Kilogram 1 Kilogram 4000 Kilogram/Month Kono Chem Co.,Ltd Contact Supplier
GMP manufacturer contrast agent Iopromide API power CAS:73334-07-3
Cas No: 73334-07-3
No Data 1 Milligram 200 Gram/Month Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd Contact Supplier
Iopromide Factory/manufacturer/seller in China CAS NO.73334-07-3
Cas No: 73334-07-3
USD $ 1.0-3.0 / Kilogram 1 Kilogram 10 Kilogram/Day Hebei yanxi chemical co.,LTD. Contact Supplier
CHemwill -- Iopromide
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USD $ 1.0-1.0 / Metric Ton 1 Metric Ton 5 Metric Ton/Day Chemwill Asia Co., Ltd. Contact Supplier
73334-07-3 Iopromide
Cas No: 73334-07-3
USD $ 40.0-50.0 / Gram 1 Gram 1000 Metric Ton/Day WUHAN MULEI NEW MATERIAL CO., LTD Contact Supplier

73334-07-3 Usage

Uses

Contrast molecule

Chemical Properties

White Solid

Uses

Labelled Iopromide. Nonionic, injectable radio-contrast medium. Diagnostic aid (radiopaque medium).

Brand name

Ultravist (Berlex).

Definition

ChEBI: A dicarboxylic acid diamide that consists of N-methylisophthalamide bearing three iodo substituents at positions 2, 4 and 6, a methoxyacetyl substituent at position 5 and two 2,3-dihydroxypropyl groups attached to the amide nitrogens. A ater soluble x-ray contrast agent for intravascular administration.
InChI:InChI=1/C18H24I3N3O8/c1-24(4-9(28)6-26)18(31)12-13(19)11(17(30)22-3-8(27)5-25)14(20)16(15(12)21)23-10(29)7-32-2/h8-9,25-28H,3-7H2,1-2H3,(H,22,30)(H,23,29)

73334-07-3 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
USP (1344804)  Iopromide  United States Pharmacopeia (USP) Reference Standard 73334-07-3 1344804-400MG 4,588.74CNY Detail
Sigma-Aldrich (Y0001022)  Iopromide for system suitability 2  European Pharmacopoeia (EP) Reference Standard 73334-07-3 Y0001022 1,880.19CNY Detail
Sigma-Aldrich (Y0001021)  Iopromide for system suitability 1  European Pharmacopoeia (EP) Reference Standard 73334-07-3 Y0001021 1,880.19CNY Detail

73334-07-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name Iopromide

1.2 Other means of identification

Product number -
Other names SHL 414C

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:73334-07-3 SDS

73334-07-3Synthetic route

C26H32I3N3O12

C26H32I3N3O12

iopromide
73334-07-3

iopromide

Conditions
ConditionsYield
With sodium methylate In methanol at 75℃; for 8h;100%
Stage #1: C26H32I3N3O12 With sodium hydroxide at 50℃; for 4h;
Stage #2: With hydrogenchloride pH=2-3;
99%
3-methylamino-propane-1,2-diol
40137-22-2

3-methylamino-propane-1,2-diol

3-[(2,3-dihydroxypropylaminoformyl)]-2,4,6-triiodo-5-[(methoxyacetyl)amino]benzoic acid methyl ester

3-[(2,3-dihydroxypropylaminoformyl)]-2,4,6-triiodo-5-[(methoxyacetyl)amino]benzoic acid methyl ester

iopromide
73334-07-3

iopromide

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine Large scale;95%
3-Amino-1,2-propanediol
616-30-8, 13552-31-3

3-Amino-1,2-propanediol

5-[(2-methoxy)acetamido]-3-(2,3-dihydroxy-N-propyl(methyl)carbamoyl)-2,4,6-triiodobenzoyl chloride

5-[(2-methoxy)acetamido]-3-(2,3-dihydroxy-N-propyl(methyl)carbamoyl)-2,4,6-triiodobenzoyl chloride

iopromide
73334-07-3

iopromide

Conditions
ConditionsYield
With sodium carbonate In N,N-dimethyl acetamide at 20℃; for 2h;92%
C18H27N3O8
1009809-16-8

C18H27N3O8

iopromide
73334-07-3

iopromide

Conditions
ConditionsYield
In water at 70 - 90℃; for 6h;88.1%
With Iodine monochloride In water at 70 - 85℃; for 3h; Temperature; Concentration;82.3 g
C25H30I3N3O13

C25H30I3N3O13

iopromide
73334-07-3

iopromide

Conditions
ConditionsYield
With sodium hydroxide at 20℃; for 5h;86%
5-methoxyacetylamino-2,4,6-triiodoisophthalic acid [(2,3-dihydroxy-N-methylpropyl)-(2,3-diacetoxypropyl)]diamide
1193076-40-2

5-methoxyacetylamino-2,4,6-triiodoisophthalic acid [(2,3-dihydroxy-N-methylpropyl)-(2,3-diacetoxypropyl)]diamide

iopromide
73334-07-3

iopromide

Conditions
ConditionsYield
With water; sodium hydroxide In N,N-dimethyl acetamide at 20 - 25℃; for 10h;85%
With water; sodium hydroxide at 20 - 25℃; for 10h; Industry scale;
5-methoxyacetamido-N-methyl-N,N'-diallyl-2,4,6-triiodoisophthalamide

5-methoxyacetamido-N-methyl-N,N'-diallyl-2,4,6-triiodoisophthalamide

iopromide
73334-07-3

iopromide

Conditions
ConditionsYield
With osmium(VIII) oxide; water; 4-methylmorpholine N-oxide In acetone at 20℃; for 13h;85%
With osmium(VIII) oxide; 4-methylmorpholine N-oxide In water; acetone at 20℃; for 12h;55.8 g
5-methoxyacetamido-2,4,6-triiodoisophthalic acid {[(2-oxo-1,3-dioxolan-4-yl)methyl]-(2,3-dihydroxy-N-methylpropyl)}diamide

5-methoxyacetamido-2,4,6-triiodoisophthalic acid {[(2-oxo-1,3-dioxolan-4-yl)methyl]-(2,3-dihydroxy-N-methylpropyl)}diamide

iopromide
73334-07-3

iopromide

Conditions
ConditionsYield
With water; sodium hydroxide at 50℃; for 0.5h;85%
With sodium hydroxide In water at 20 - 50℃; for 0.5h;85%
2,4,6-triiodo-5-(2-methoxyacetamido)-N1-methyl-N1,N3-bis-((2-oxo-1,3-dioxolane-4-yl)methyl)isophthalamide

2,4,6-triiodo-5-(2-methoxyacetamido)-N1-methyl-N1,N3-bis-((2-oxo-1,3-dioxolane-4-yl)methyl)isophthalamide

iopromide
73334-07-3

iopromide

Conditions
ConditionsYield
With sodium hydroxide at 20℃; for 3h;80%
C30H40I3N3O16

C30H40I3N3O16

iopromide
73334-07-3

iopromide

Conditions
ConditionsYield
With sodium hydroxide at 0 - 50℃;80%
C46H40I3N3O12

C46H40I3N3O12

iopromide
73334-07-3

iopromide

Conditions
ConditionsYield
With sodium hydroxide at 0 - 50℃;80%
Stage #1: C46H40I3N3O12 With sodium hydroxide at 0 - 50℃; for 4h;
Stage #2: With hydrogenchloride In water at 0 - 20℃; pH=7;
2,4,6-triiodo-5-(2-methoxyacetamido)-N1-methyl-N1,N3-bis-((2-oxo-1,3,2-dioxathiolan-4-yl)methyl)isophthalamide

2,4,6-triiodo-5-(2-methoxyacetamido)-N1-methyl-N1,N3-bis-((2-oxo-1,3,2-dioxathiolan-4-yl)methyl)isophthalamide

iopromide
73334-07-3

iopromide

Conditions
ConditionsYield
With sodium hydroxide at 20℃; for 3h;75%
5-methoxyacetylamino-2,4,6-triiodoisophthalic acid (2,3-dihydroxypropyl)amide chloride

5-methoxyacetylamino-2,4,6-triiodoisophthalic acid (2,3-dihydroxypropyl)amide chloride

3-methylamino-propane-1,2-diol
40137-22-2

3-methylamino-propane-1,2-diol

pyrographite
7440-44-0

pyrographite

iopromide
73334-07-3

iopromide

Conditions
ConditionsYield
With tributyl-amine In dichloromethane; water; N,N-dimethyl-formamide
N1-(2,3-dihydroxypropyl)-N1-methyl-5-nitro-N3-((2-oxo-1,3-dioxolan-4-yl)methyl)isophthalamide

N1-(2,3-dihydroxypropyl)-N1-methyl-5-nitro-N3-((2-oxo-1,3-dioxolan-4-yl)methyl)isophthalamide

iopromide
73334-07-3

iopromide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: palladium 10% on activated carbon; hydrogen / methanol / 5 h / 20 °C / 30003 Torr
2: hydrogenchloride; sodium iodide dichloride / water / 80 °C
3: pyridine / 1,2-dimethoxyethane / 6 h / 50 °C
4: sodium hydroxide / 5 h / 20 °C
View Scheme
N1-(2,3-dihydroxypropyl)-N1-methyl-5-amino-N3-((2-oxo-1,3-dioxolan-4-yl)methyl)isophthalamide

N1-(2,3-dihydroxypropyl)-N1-methyl-5-amino-N3-((2-oxo-1,3-dioxolan-4-yl)methyl)isophthalamide

iopromide
73334-07-3

iopromide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: hydrogenchloride; sodium iodide dichloride / water / 80 °C
2: pyridine / 1,2-dimethoxyethane / 6 h / 50 °C
3: sodium hydroxide / 5 h / 20 °C
View Scheme
5-nitro-1,3-benzenedicarboxylic acid, monomethyl ester
1955-46-0

5-nitro-1,3-benzenedicarboxylic acid, monomethyl ester

iopromide
73334-07-3

iopromide

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: acetonitrile / 7 h / 75 - 80 °C
2.1: triethylamine / N,N-dimethyl-formamide / 1 h / 0 - 20 °C
3.1: oxalyl dichloride / dichloromethane / 1 h / 0 - 20 °C
3.2: 2.5 h / -10 °C
4.1: palladium 10% on activated carbon; hydrogen / methanol / 5 h / 20 °C / 30003 Torr
5.1: hydrogenchloride; sodium iodide dichloride / water / 80 °C
6.1: pyridine / 1,2-dimethoxyethane / 6 h / 50 °C
7.1: sodium hydroxide / 5 h / 20 °C
View Scheme
Multi-step reaction with 7 steps
1.1: oxalyl dichloride / dichloromethane / 20 °C
1.2: 4.5 h / 0 °C
2.1: N,N-dimethyl-formamide / 5 h / 70 - 80 °C
3.1: thionyl chloride / 2 h / 10 - 20 °C
4.1: zinc / methanol / 0.17 h
4.2: 5 h / 20 °C
5.1: hydrogenchloride; sodium iodide dichloride / water / 20 - 80 °C
6.1: N,N-dimethyl acetamide / 10 h / 0 - 20 °C
7.1: sodium hydroxide / 3 h / 20 °C
View Scheme
Multi-step reaction with 7 steps
1.1: oxalyl dichloride / dichloromethane / 20 °C
1.2: 4.5 h / 0 °C
2.1: N,N-dimethyl-formamide / 6 h / 70 - 80 °C
3.1: thionyl chloride / 2 h / 10 - 20 °C
4.1: zinc / methanol / 0.17 h
4.2: 5 h / 20 °C
5.1: hydrogenchloride; sodium iodide dichloride / water / 20 - 80 °C
6.1: N,N-dimethyl acetamide / 10 h / 0 - 20 °C
7.1: sodium hydroxide / 3 h / 20 °C
View Scheme
3-((2,3-dihydroxypropyl)carbamoyl)-5-nitrobenzoic acid
122731-58-2

3-((2,3-dihydroxypropyl)carbamoyl)-5-nitrobenzoic acid

iopromide
73334-07-3

iopromide

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: triethylamine / N,N-dimethyl-formamide / 1 h / 0 - 20 °C
2.1: oxalyl dichloride / dichloromethane / 1 h / 0 - 20 °C
2.2: 2.5 h / -10 °C
3.1: palladium 10% on activated carbon; hydrogen / methanol / 5 h / 20 °C / 30003 Torr
4.1: hydrogenchloride; sodium iodide dichloride / water / 80 °C
5.1: pyridine / 1,2-dimethoxyethane / 6 h / 50 °C
6.1: sodium hydroxide / 5 h / 20 °C
View Scheme
3-nitro-5-(((2-oxo-1,3-dioxolan-4-yl)methyl)carbamoyl)benzoic acid

3-nitro-5-(((2-oxo-1,3-dioxolan-4-yl)methyl)carbamoyl)benzoic acid

iopromide
73334-07-3

iopromide

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: oxalyl dichloride / dichloromethane / 1 h / 0 - 20 °C
1.2: 2.5 h / -10 °C
2.1: palladium 10% on activated carbon; hydrogen / methanol / 5 h / 20 °C / 30003 Torr
3.1: hydrogenchloride; sodium iodide dichloride / water / 80 °C
4.1: pyridine / 1,2-dimethoxyethane / 6 h / 50 °C
5.1: sodium hydroxide / 5 h / 20 °C
View Scheme
3-((2,3-dihydroxypropyl)methylcarbamoyl)-5-nitrobenzoic acid methyl ester

3-((2,3-dihydroxypropyl)methylcarbamoyl)-5-nitrobenzoic acid methyl ester

iopromide
73334-07-3

iopromide

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: N,N-dimethyl-formamide / 6 h / 70 - 80 °C
2.1: thionyl chloride / 2 h / 10 - 20 °C
3.1: zinc / methanol / 0.17 h
3.2: 5 h / 20 °C
4.1: hydrogenchloride; sodium iodide dichloride / water / 20 - 80 °C
5.1: N,N-dimethyl acetamide / 10 h / 0 - 20 °C
6.1: sodium hydroxide / 3 h / 20 °C
View Scheme
Multi-step reaction with 6 steps
1: N,N-dimethyl-formamide / 6 h / 70 - 80 °C
2: triethylamine / tetrahydrofuran / 1 h / 10 - 20 °C
3: palladium 10% on activated carbon / methanol / 20 °C / 30003 Torr
4: hydrogenchloride; sodium iodide dichloride / water / 20 - 80 °C
5: N,N-dimethyl acetamide / 10 h / 0 - 20 °C
6: sodium hydroxide / 3 h / 20 °C
View Scheme
N1,N3-bis-(2,3-dihydroxypropyl)-N1-methyl-5-nitroisophthalamide

N1,N3-bis-(2,3-dihydroxypropyl)-N1-methyl-5-nitroisophthalamide

iopromide
73334-07-3

iopromide

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: thionyl chloride / 2 h / 10 - 20 °C
2.1: zinc / methanol / 0.17 h
2.2: 5 h / 20 °C
3.1: hydrogenchloride; sodium iodide dichloride / water / 20 - 80 °C
4.1: N,N-dimethyl acetamide / 10 h / 0 - 20 °C
5.1: sodium hydroxide / 3 h / 20 °C
View Scheme
Multi-step reaction with 5 steps
1: triethylamine / tetrahydrofuran / 1 h / 10 - 20 °C
2: palladium 10% on activated carbon / methanol / 20 °C / 30003 Torr
3: hydrogenchloride; sodium iodide dichloride / water / 20 - 80 °C
4: N,N-dimethyl acetamide / 10 h / 0 - 20 °C
5: sodium hydroxide / 3 h / 20 °C
View Scheme
Multi-step reaction with 4 steps
1: palladium 10% on activated carbon; hydrogen / water / 7 h / 20 °C / 30003 - 33753.4 Torr
2: potassium iodide; sodium chloride; Iodine monochloride; sulfuric acid / water / 24 h / 50 °C
3: N,N-dimethyl acetamide / 0 - 30 °C
4: sodium hydroxide / 0 - 50 °C
View Scheme
Multi-step reaction with 5 steps
1: palladium 10% on activated carbon; hydrogen / water / 7 h / 20 °C / 30003 - 33753.4 Torr
2: potassium iodide; sodium chloride; Iodine monochloride; sulfuric acid / water / 24 h / 50 °C
3: triethylamine / N,N-dimethyl acetamide / 50 °C
4: N,N-dimethyl acetamide / 3.5 h / 10 - 30 °C
5: sodium methylate / methanol / 8 h / 75 °C
View Scheme
Multi-step reaction with 5 steps
1.1: hydrazine hydrate / 10 - 15 °C
2.1: potassium iodide; sodium chloride; sulfuric acid; Iodine monochloride / water / 8 h / 50 °C
3.1: triethylamine / N,N-dimethyl acetamide / 50 °C
4.1: N,N-dimethyl acetamide / 3.5 h / 10 - 30 °C
5.1: sodium hydroxide / 4 h / 50 °C
5.2: pH 2-3
View Scheme
N-methyl-5-nitro-N1,N3-bis-((2-oxo-1,3-dioxolan-4-yl)methyl)isophthalamide

N-methyl-5-nitro-N1,N3-bis-((2-oxo-1,3-dioxolan-4-yl)methyl)isophthalamide

iopromide
73334-07-3

iopromide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: palladium 10% on activated carbon / methanol / 20 °C / 30003 Torr
2: hydrogenchloride; sodium iodide dichloride / water / 20 - 80 °C
3: N,N-dimethyl acetamide / 10 h / 0 - 20 °C
4: sodium hydroxide / 3 h / 20 °C
View Scheme
N-methyl-5-amino-N1,N3-bis-((2-oxo-1,3-dioxolan-4-yl)methyl)isophthalamide

N-methyl-5-amino-N1,N3-bis-((2-oxo-1,3-dioxolan-4-yl)methyl)isophthalamide

iopromide
73334-07-3

iopromide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: hydrogenchloride; sodium iodide dichloride / water / 20 - 80 °C
2: N,N-dimethyl acetamide / 10 h / 0 - 20 °C
3: sodium hydroxide / 3 h / 20 °C
View Scheme
5-amino-2,4,6-triiodo-N1-methyl-N1,N3-bis-((2-oxo-1,3-dioxolan-4-yl)methyl)isophthalamide

5-amino-2,4,6-triiodo-N1-methyl-N1,N3-bis-((2-oxo-1,3-dioxolan-4-yl)methyl)isophthalamide

iopromide
73334-07-3

iopromide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: N,N-dimethyl acetamide / 10 h / 0 - 20 °C
2: sodium hydroxide / 3 h / 20 °C
View Scheme
N-methyl-5-nitro-N1,N3-bis-((2-oxo-1,3,2-dioxathiolan-4-yl)methyl)isophthalamide

N-methyl-5-nitro-N1,N3-bis-((2-oxo-1,3,2-dioxathiolan-4-yl)methyl)isophthalamide

iopromide
73334-07-3

iopromide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: zinc / methanol / 0.17 h
1.2: 5 h / 20 °C
2.1: hydrogenchloride; sodium iodide dichloride / water / 20 - 80 °C
3.1: N,N-dimethyl acetamide / 10 h / 0 - 20 °C
4.1: sodium hydroxide / 3 h / 20 °C
View Scheme
N-methyl-5-amino-N1,N3-bis-((2-oxo-1,3,2-dioxathiolan-4-yl)methyl)isophthalamide

N-methyl-5-amino-N1,N3-bis-((2-oxo-1,3,2-dioxathiolan-4-yl)methyl)isophthalamide

iopromide
73334-07-3

iopromide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: hydrogenchloride; sodium iodide dichloride / water / 20 - 80 °C
2: N,N-dimethyl acetamide / 10 h / 0 - 20 °C
3: sodium hydroxide / 3 h / 20 °C
View Scheme
methyl 3-((2,3-dihydroxypropyl)carbamoyl)-5-nitrobenzoate

methyl 3-((2,3-dihydroxypropyl)carbamoyl)-5-nitrobenzoate

iopromide
73334-07-3

iopromide

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: N,N-dimethyl-formamide / 5 h / 70 - 80 °C
2.1: thionyl chloride / 2 h / 10 - 20 °C
3.1: zinc / methanol / 0.17 h
3.2: 5 h / 20 °C
4.1: hydrogenchloride; sodium iodide dichloride / water / 20 - 80 °C
5.1: N,N-dimethyl acetamide / 10 h / 0 - 20 °C
6.1: sodium hydroxide / 3 h / 20 °C
View Scheme
Multi-step reaction with 6 steps
1: N,N-dimethyl-formamide / 5 h / 70 - 80 °C
2: triethylamine / tetrahydrofuran / 1 h / 10 - 20 °C
3: palladium 10% on activated carbon / methanol / 20 °C / 30003 Torr
4: hydrogenchloride; sodium iodide dichloride / water / 20 - 80 °C
5: N,N-dimethyl acetamide / 10 h / 0 - 20 °C
6: sodium hydroxide / 3 h / 20 °C
View Scheme
Multi-step reaction with 5 steps
1: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 20 - 25 °C
2: palladium 10% on activated carbon; hydrogen / water / 7 h / 20 °C / 30003 - 33753.4 Torr
3: potassium iodide; sodium chloride; Iodine monochloride; sulfuric acid / water / 24 h / 50 °C
4: N,N-dimethyl acetamide / 0 - 30 °C
5: sodium hydroxide / 0 - 50 °C
View Scheme
5-amino-2,4,6-triiodo-N1-methyl-N1,N3-bis-((2-oxo-1,3,2-dioxathiolan-4-yl))isophthalamide

5-amino-2,4,6-triiodo-N1-methyl-N1,N3-bis-((2-oxo-1,3,2-dioxathiolan-4-yl))isophthalamide

iopromide
73334-07-3

iopromide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: N,N-dimethyl acetamide / 10 h / 0 - 20 °C
2: sodium hydroxide / 3 h / 20 °C
View Scheme
2,4,6-triiodo-5-aminoisophthalic acid
35453-19-1

2,4,6-triiodo-5-aminoisophthalic acid

iopromide
73334-07-3

iopromide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: sulfuric acid / 4 h / Reflux; Large scale
2: 1,4-dioxane / 4 h / Reflux; Large scale
3: N-ethyl-N,N-diisopropylamine / 1,2-dimethoxyethane / 18 h / Reflux; Large scale
4: N-ethyl-N,N-diisopropylamine / Large scale
View Scheme
dimethyl 5-amino-2,4,6-triiodo-1,3-benzenedicarboxylate
154921-11-6

dimethyl 5-amino-2,4,6-triiodo-1,3-benzenedicarboxylate

iopromide
73334-07-3

iopromide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 1,4-dioxane / 4 h / Reflux; Large scale
2: N-ethyl-N,N-diisopropylamine / 1,2-dimethoxyethane / 18 h / Reflux; Large scale
3: N-ethyl-N,N-diisopropylamine / Large scale
View Scheme
3-amino-5-(2,3-dihydroxy-n-propylaminoformyl)benzoic acid methyl ester

3-amino-5-(2,3-dihydroxy-n-propylaminoformyl)benzoic acid methyl ester

iopromide
73334-07-3

iopromide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: sulfuric acid / 12 h / 40 °C
2.1: sodium methylate / methanol / 6 h / Reflux
2.2: 3 h / 30 - 50 °C
3.1: Iodine monochloride / water / 3 h / 70 - 85 °C
View Scheme
iopromide
73334-07-3

iopromide

5-methoxyacetylamino-2,4,6-triiodo-isophthalic acid [(2,3-dihydroxy-N-methyl-propyl)-(2,3-dihydroxypropyl)]-diamide

5-methoxyacetylamino-2,4,6-triiodo-isophthalic acid [(2,3-dihydroxy-N-methyl-propyl)-(2,3-dihydroxypropyl)]-diamide

5-methoxyacetylamino-2,4,6-triiodo-isophthalic acid [(2,3-dihydroxy-N-methyl-propyl)-(2,3-dihydroxypropyl)]-diamide

5-methoxyacetylamino-2,4,6-triiodo-isophthalic acid [(2,3-dihydroxy-N-methyl-propyl)-(2,3-dihydroxypropyl)]-diamide

Conditions
ConditionsYield
In propan-1-ol at 65℃; for 48h; Purification / work up;
In water at 208 - 209℃; under 15001.5 Torr; Purification / work up;

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