28203-54-5

Upstream product

• 103-46-8 S-benzylmercaptoacetic acid 
• 100-51-6 benzyl alcohol 
• 930-69-8 sodium thiophenolate 
• 100-44-7 benzyl chloride 
• 68-11-1 mercaptoacetic acid 
• 96-34-4 methyl chloroacetate 
• 100-39-0 benzyl bromide 

Downstream Products

• 858255-21-7 benzylsulfanyl-hydroxy-acetic acid 
• 150-60-7 dibenzyl disulphide 
• 17297-81-3 bis-benzylsulfanyl-acetic acid 
• 298-12-4 Glyoxilic acid 
• 22938-45-0 N,N'-bis-benzenesulfonyl-C-phenyl-methanesulfinamidine 
• 1609007-99-9 E-acetic acid 2-acetoxy-4-[2-(phenylmethanesulfinyl)vinyl]phenyl ester 
• 28203-59-0 (benzylsulfonyl)acetic acid 

Relevant academic research and scientific papers

Influence of sulfur groups on carboxylic acid strengths

The relative acid strength for a series of monocarboxylic acids of the general formula R–X–(CH2)n–COOH and related dicarboxylic acids of the general formula HOOC–(CH2)n–X–(CH2)n–COOH, where R = Ph or Me, X = CH2, –S– –SO– or –SO2–; and n = 1 or 2 as appropriate; have been studied as a function of X. It is found that sulfur containing acids have lower pKa values than the corresponding carbon analogues, that the pKa is highest for the thioacids and lowest for the sulfonyl acids, that the pKas increase as n increases, and that for the dicarboxylic acid systems only the thio members show a significant reduction in pKa (2) – pKa (1) differences upon changing n from 1 to 2.

Sodium sulfate-hydrogen peroxide-sodium chloride adduct: selective protocol for the oxidative bromination, iodination and temperature dependent oxidation of sulfides to sulfoxides and sulfones

The regioselective bromination and iodination of unprotected aromatic primary amines using enclathrated hydrogen peroxide as an oxidant under mild conditions has been developed, in which potassium bromide (KBr) and potassium iodide (KI) were used as brominating and iodinating agents, respectively. The adduct shows not only regioselectivity for para- or ortho-isomers but also a remarkable chemoselectivity for monobromination. Selective oxidation of sulfides to sulfoxides and sulfones has also been studied and good to excellent yields of the desired products were obtained. Acetic acid was found to be the solvent of choice for these reactions. This simple method represents an ecologically benign and alternative pathway for the oxidative halogenation of anilines and the oxidation of sulfides to sulfoxides and sulfones.

Nonanebis(peroxoic acid) mediated efficient and selective oxidation of sulfide

Two efficient and rapid protocols for the selective oxidation of sulfide in the presence of various oxidizable functionalities such as -CHO, -CH2-OH, alkene and tert amine were investigated, using nonanebis(peroxoic acid) as an oxidant. The acetonitrile based system offers selective oxidation to sulfoxide and sulfone, while the water based system gives selective sulfone formation with a high conversion and 90-100% selectivity. Recovery and recycling of the parent acid of up to 75-80% was achieved in the water based protocol.

E-3,4-di-calcium method for preparing vinyl sulfoxide compound thereof as a neuroprotective pharmaceutical application

The invention relates to an application of E-3,4-dihydroxyphenylvinyl sulfoxide represented by the formula I in preparation of nerve protection drugs for treating neurodegenerative diseases, wherein the definitions of each group in the formula I are listed in the description. The invention also relates to a preparation method of E-3,4-dihydroxyphenylvinyl sulfoxide.

Design, synthesis, and biological evaluation of (E)-3,4-dihydroxystyryl aralkyl sulfones and sulfoxides as novel multifunctional neuroprotective agents

Novel (E)-3,4-dihydroxystyryl aralkyl sulfones and sulfoxides were designed and synthesized as new analogues of 1, which showed interesting multifunctional neuroprotective effects, including antioxidative and antineuroinflammatory properties. Specifically, target compounds display excellent potency in scavenging reactive free radicals and demonstrate potent effects against various kinds of toxicities, including H2O2, 6-hydroxydopamine, and lipopolysaccharide in different types of neuronal cells. The antioxidative properties of the target compounds are more potent than that of 1, and the antineuroinflammatory properties are less strong than that of 1. According to the parallel artificial membrane permeation assay for the blood-brain barrier, target compounds possess greater blood-brain barrier (BBB) permeability than 1. In short, due to improvement of the antioxidative effect, stability, and BBB permeability, (E)-3,4-dihydroxystyryl aralkyl sulfones and sulfoxides can thus be considered as potential multifunctional neuroprotective agents and serve as new lead candidates in the treatment of neurodegenerative diseases.

INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE

The present invention comprises analogs of the CAAX motif of the protein Ras that is modified by farnesylation in vivo. These CAAX analogs inhibit the farnesylation of Ras. Furthermore, these CAAX analogues differ from those previously described as inhibi

Cis-platinum complexes with chelating amines and sulphinyl carboxylates

STR1 Platinum (II) complexes of formula (I) where: Am is a monodentate amine, or (Am)2 is a bidentate amine, B represents a straight or branched alkyl residue or a single bond, R is selected from the group of hydrogen, (C3 -C8) cycloalkyl, phenyl or naphthyl which may be substituted by halogens (I, Br, Cl, F), trihalomethane, hydroxyl, (C1 -C4)-alkoxyl, (C1 -C7)-acylamino, (C1 -C7)-sulphamido, allyl, phenoxyl, haloalkoxyl, nitro, cyano, azido, with condition that when R is hydrogen B is different from a single bond, Q is a residue of formula --(CH2)n1 --CRa Rb --(CH2)n2 --, 1,2- or 2,3-naphthalene, benzo-1,3-dioxolan-5,6-diyl, substituted or unsubstituted 1,2-phenylene, Ra and Rb are selected independently of each other from the group of hydrogen, allyl, linear or branched (C1 -C8)-alkyl, --(CH2)p OH, --(CH2 CH2 O)q --CH3, or taken together with the carbon atom to which they are bonded form a (C3 -C8) cycloalkyl, or heterocyclic tetrahydropyran-4,4-diyl, n1 and n2 are independently zero or the integer 1, p is an integer from 2 to 6, and q is an integer from 1-3, X- is a biocompatible anion such as chloride, bromide, iodide, nitrate, perchlorate, or one equivalent of sulphate or phosphate, or an anion of a monovalent C1 -C4 organic acid such as acetate, propionate or chloroacetate, or of an aromatic acid such as benzoate, or of a heteroaromatic acid such as nicotinate are described. The compounds are useful as anti-tumor drugs.

2-sulphinyl-acetyl-1,3-thiazolidines, their preparation and pharmaceutical compositions

Thiazolidines of formula I STR1 wherein R is H, C1 -C4 -alkyl, allyl or propargyl; X is O, CH2, S; R1 is C1 -C6 -linear or branched alkyl, phenyl, benzyl, or a group of formula CH2 --CH2 --O--(CH2 --CH2 --O)n --Ra wherein n is zero or an integer from 1 to 3 and Ra is H, benzyl or C1 -C6 -linear or branched alkyl. Compounds I are endowed with favourable therapeutical properties for pathologies of the respiratory system.

2-Sulphinyl-acetyl-1,3-thiazolidines, their preparation and pharmaceutical compositions

Thiazolidines of formula I - wherein R is H, C1-C4-alkyl, allyl or propargyl;, - X is O, CH2, S;, - R1 is C1-C6-linear or branched alkyl, phenyl, benzyl, or a group of formula CH2-CH2-O-(CH2-CH2-O)n-Ra, wherein n is zero or an integer from 1 to 3 and Ra is H, benzyl or C1-C6-linear or branched alkyl. Compounds I are endowed with favourable therapeuti-cal properties for pathologies of the respiratory system.