28224-74-0

Upstream product

• 28224-73-9 1,3:4,6-di-O-benzylidene-D-mannitol 
• 124-63-0 methanesulfonyl chloride 
• 100-52-7 benzaldehyde 
• 69-65-8 mannitol 

Downstream Products

• 144266-28-4 2,5-dideoxy-2,5-N-benzylimino-1,3:4,6-di-O-benzylidene-L-iditol 
• 213764-69-3 (4aR,5aR,9aS,9bS)-5-Hexyl-2,8-diphenyl-hexahydro-bis[1,3]dioxino[5,4-b;4',5'-d]pyrrole 
• 111248-46-5 N-amino-1,3:4,6-di-O-benzylidene-2,5-dideoxy-2,5-imino-L-iditol 
• 144266-29-5 1,2-Bis-((2R,4aS,5aS,8R,9aR,9bR)-2,8-diphenyl-hexahydro-bis[1,3]dioxino[5,4-b;4',5'-d]pyrrol-5-yl)-ethane-1,2-dione 
• 134933-63-4 (2S,3R,4R,5S)-1-Benzyl-3,4-bis-benzyloxy-2,5-bis-benzyloxymethyl-pyrrolidine 
• 144266-33-1 2-((2R,4aS,5aS,8R,9aR,9bR)-2,8-Diphenyl-hexahydro-bis[1,3]dioxino[5,4-b;4',5'-d]pyrrol-5-yl)-1,1-diphenyl-ethanol 
• 144397-81-9 (2S,3R,4R,5S)-1-Benzyl-2,5-bis-hydroxymethyl-pyrrolidine-3,4-diol; hydrochloride 
• 144266-31-9 ((2R,4aS,5aS,8R,9aR,9bR)-2,8-Diphenyl-hexahydro-bis[1,3]dioxino[5,4-b;4',5'-d]pyrrol-5-yl)-acetic acid ethyl ester 
• 144266-42-2 2-((2R,4aS,5aS,8R,9aR,9bR)-2,8-Diphenyl-hexahydro-bis[1,3]dioxino[5,4-b;4',5'-d]pyrrol-5-yl)-ethanol 
• 105015-44-9 (2S,3R,4R,5S)-3,4-dihydroxy-2,5-bis(hydroxymethyl)pyrrolidine 
• 130282-82-5 D_g-threo-dibenzoyloxy-hexadiene-(1.5) 
• 1069-23-4 (3R,4R)-1,5-hexadiene-3,4-diol 
• 133443-76-2 (2R,4aS,5aS,8R,9aR,9bR)-Perhydro-2,8-diphenyl-2H,5H,8H-bis<1,3>dioxino<5,4-b:4',5'-d>pyrrole 
• 913534-57-3 1,3:4,6-di-O-benzylidene-2,5-dideoxy-1,5-[[(2S,3S)-2,4-O-benyzlidene-2,4-dihydroxy-3-(sulfooxy)butyl]iminonium]-L-iditol 

Relevant academic research and scientific papers

Synthesis of new analogues of salacinol containing a pendant hydroxymethyl group as potential glycosidase inhibitors

The synthesis of new analogues of the naturally occurring glycosidase inhibitor, salacinol, and its ammonium analogue, ghavamiol is described. These analogues contain an additional hydroxymethyl group at C-1, which was intended to form additional polar co

Synthesis of C2-symmetric guanidino-sugars as potent inhibitors of glycosidases

A series of enantiomerically pure C2-Symmetric guanidino-sugars was synthesized from D-mannitol. The first method described involves direct opening of a bis-epoxide by guanidine, whereas the second one deals with a mercury-catalyzed transformation of a cyclic thiourea into a N,N',N'- trisubstituted guanidine as a key step. The biological activity of these compounds towards several glycosidases has been evaluated. One of them (5) was found to selectively inhibit α-L-fucosidase of bovin kidney (2.8 μM). (C) 2000 Elsevier Science Ltd.

Synthesis of amphiphilic polyhydroxylated pyrrolidines as potential glycosidase inhibitors

Several polyhydroxylated pyrrolidines with an aliphatic long chain on the ring nitrogen were prepared starting from D-mannitol. An amphiphilic bis- azasugar scaffold has been also prepared. These products behave as cationic surfactants and show a promising anti HIV-1 activity.

Short-step synthesis of chiral C2-symmetric 2,3,4,5-tetrasubstituted pyrrolidines from D-mannitol and their use as chiral ligands in the reaction of diethylzinc and benzaldehyde

(3R,4R)-bis(hydroxy)-(2S,5S)-bis(hydroxymethyl)-pyrrolidine and related chiral C2-symmetric pyrrolidines including D2-symmetric 1,2-bis(1-pyrrolidino)-ethanes and N-hydroxyethylpyrrolidines were synthesized highly practically from D-