28267-45-0

Basic information

• Product Name: 2,4(1H,3H)-pyrimidinedione, 1,3-dimethyl-6-propyl-
• Synonyms: 1,3-Dimethyl-6-propylpyrimidine-2,4(1H,3H)-dione
• CAS NO: 28267-45-0
• Molecular Formula: C₉H₁₄N₂O₂
• Molecular Weight: 182.2197
• Mol File: 28267-45-0.mol
• Article Data: 1

Chemical Properties

• Melting Point: 60-61 °C
• Boiling Point: 258.676°C at 760 mmHg
• Flash Point: 101.212°C
• Density: 1.092g/cm³
• Vapor Pressure: 0.014mmHg at 25°C
• Refractive Index: 1.497
• PKA: -2.01±0.40(Predicted)
• CAS DataBase Reference: 2,4(1H,3H)-pyrimidinedione, 1,3-dimethyl-6-propyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4(1H,3H)-pyrimidinedione, 1,3-dimethyl-6-propyl-(28267-45-0)
• EPA Substance Registry System: 2,4(1H,3H)-pyrimidinedione, 1,3-dimethyl-6-propyl-(28267-45-0)

Safety Data

• Hazardous Substances Data: 28267-45-0(Hazardous Substances Data)

Upstream product

• 13345-08-9 6-propyl(1H,3H)pyrimidine-2,4-dione 
• 77-78-1 dimethyl sulfate 
• 51-52-5 propylthiouracil 
• 13509-52-9 1,3,6-trimethyluracil 
• 75-03-6 ethyl iodide 

Relevant articles and documents

Research on antiviral agents. 5.1 lithiation of 6-methyluracil as a new and efficient entry to C(6)-substituted uracils

Synthesis of numerous C(6)-substituted uracits can be effected by lithiation of N(1), N(3)-substituted 6-methyluracils (1) and (4) with LiHMDS, followed by the reaction of the resulting lithio derivatives with carbon, sulfur, and selenium electrophiles. The unexpected migration of the N(1)-benzoyl group in the melalation-alkylation and the high stereoselectivity obtained in the reaction with substituted cyclohexanones are also reported.