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Product FOB Price Min.Order Supply Ability Supplier
PROPYLTHIOURACIL
Cas No: 51-52-5
USD $ 1.0-1.0 / Gram 1 Gram 10000 Kilogram/Day Ningbo Qicheng Chemical Co.,Ltd. Contact Supplier
Propylthiouracil manufacturer with low price
Cas No: 51-52-5
No Data 1 Gram 1000 Metric Ton/Month Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd Contact Supplier
51-52-5 4(1H)-Pyrimidinone,2,3-dihydro-6-propyl-2-thioxo-
Cas No: 51-52-5
USD $ 40.0-50.0 / Gram 1 Gram 1000 Metric Ton/Day WUHAN MULEI NEW MATERIAL CO., LTD Contact Supplier
USP standard Propylthiouracil CAS 51-52-5 supplied by manufacturer
Cas No: 51-52-5
No Data No Data 20 Metric Ton/Month Wuhan Fortuna Chemical Co.,Ltd Contact Supplier
6-Propyl-2-thiouracil
Cas No: 51-52-5
No Data No Data No Data Chemwill Asia Co., Ltd. Contact Supplier
Propylthiouracil
Cas No: 51-52-5
USD $ 3.0-3.0 / Kilogram 1 Kilogram 1-10 Metric Ton/Month Dayang Chem (Hangzhou) Co.,Ltd. Contact Supplier
Factory 6-Propyl-2-thiouracil in stock CAS 51-52-5
Cas No: 51-52-5
No Data 1 Gram 1 Metric Ton/Month Shaanxi Mingqi Chemical Co., Ltd Contact Supplier
Factory Supply Propylthiouracil
Cas No: 51-52-5
No Data 100 Gram 400 Metric Ton/Day Ality Chemical Corporation Contact Supplier
Pharmaceutical Intermediate Propylthiouracil CAS 51-52-5
Cas No: 51-52-5
No Data 100 Gram 20000 Kilogram/Day Hubei XinRunde Chemical Co., Ltd Contact Supplier
Pharmaceutical Grade CAS 51-52-5 with competitive price
Cas No: 51-52-5
USD $ 139.0-210.0 / Kilogram 1 Kilogram 1000 Kilogram/Day Zhuozhou Wenxi import and Export Co., Ltd Contact Supplier

51-52-5 Usage

Definition

ChEBI: A pyrimidinethione consisting of uracil in which the 2-oxo group is substituted by a thio group and the hydrogen at position 6 is substituted by a propyl group.

Chemical Properties

White Crystalline Powder

Air & Water Reactions

Sensitive to light. May be sensitive to prolonged exposure to air. Insoluble in water.

Fire Hazard

Flash point data for Propylthiouracil are not available; however Propylthiouracil is probably combustible.

General Description

Odorless white crystalline powder of starch-like appearance. Bitter taste. Saturated solution is neutral or slightly acid to litmus.

Purification Methods

Purify propacil by recrystallisation from H2O (soluble in 900 parts at 20o, and 100 parts at 100o). UV, MeOH: max 277nm. [Anderson et al. J Am Chem Soc 67 2197 1945, Vanderhaegue Bull Soc Chim Belg 59 689 1950, Beilstein 24 III/IV 1333.]

Reactivity Profile

Propylthiouracil is incompatible with strong oxidizing agents, strong acids and strong bases. Forms complexes with divalent metals. Reacts with sulfhydryl-oxidizing agents . When reduced will produce hydrogen sulfide.

Uses

Antihyperthyroid. Has been used to promote fattening. This substance is reasonably anticipated to be a human carcinogen

Uses

antibacterial
InChI:InChI=1/C7H10N2OS/c1-2-4-9-5-3-6(10)8-7(9)11/h3,5H,2,4H2,1H3,(H,8,10,11)

51-52-5 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
Sigma-Aldrich (46698)  6-Propyl-2-thiouracil  VETRANAL, analytical standard 51-52-5 46698-250MG 329.94CNY Detail
USP (1578000)  Propylthiouracil  United States Pharmacopeia (USP) Reference Standard 51-52-5 1578000-200MG 4,662.45CNY Detail
TCI America (P0533)  6-Propyl-2-thiouracil  >99.0%(T) 51-52-5 25g 160.00CNY Detail

51-52-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name 6-propyl-2-thiouracil

1.2 Other means of identification

Product number -
Other names 4(1H)-Pyrimidinone, 2,3-dihydro-6-propyl-2-thioxo-

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:51-52-5 SDS

51-52-5Synthetic route

ethyl butyroyl acetate
3249-68-1

ethyl butyroyl acetate

thiourea
17356-08-0

thiourea

propylthiouracil
51-52-5

propylthiouracil

Conditions
ConditionsYield
Reflux;81%
With potassium hydroxide In ethanol at 80℃; for 5h;41%
With sodium ethanolate
thiourea
17356-08-0

thiourea

methyl 3-oxohexanoate
30414-54-1

methyl 3-oxohexanoate

propylthiouracil
51-52-5

propylthiouracil

Conditions
ConditionsYield
With potassium carbonate In water at 70 - 105℃; for 3h;78%
With sodium ethanolate In ethanol at 100℃; Inert atmosphere;33%
Heating;
propylthiouracil
51-52-5

propylthiouracil

Cyclohexyl isocyanide
931-53-3

Cyclohexyl isocyanide

dimethyl acetylenedicarboxylate
762-42-5

dimethyl acetylenedicarboxylate

dimethyl 2-(cyclohexylamino)-4,8-dihydro-8-oxo-6-propylpyrimido[2,1-b][1,3]thiazine-3,4-dicarboxylate

dimethyl 2-(cyclohexylamino)-4,8-dihydro-8-oxo-6-propylpyrimido[2,1-b][1,3]thiazine-3,4-dicarboxylate

Conditions
ConditionsYield
In toluene for 1h; Reflux;94%
propylthiouracil
51-52-5

propylthiouracil

1,1,3,3-tetramethylbutane isonitrile
14542-93-9

1,1,3,3-tetramethylbutane isonitrile

dimethyl acetylenedicarboxylate
762-42-5

dimethyl acetylenedicarboxylate

dimethyl 2-(2,4,4-trimethylpentan-2-ylamino)-4,8-dihydro-8-oxo-6-propylpyrimido[2,1-b][1,3]thiazine-3,4-dicarboxylate

dimethyl 2-(2,4,4-trimethylpentan-2-ylamino)-4,8-dihydro-8-oxo-6-propylpyrimido[2,1-b][1,3]thiazine-3,4-dicarboxylate

Conditions
ConditionsYield
In toluene for 1h; Reflux;93%
propylthiouracil
51-52-5

propylthiouracil

2,6-dimethylphenyl isonitrile
119072-54-7, 2769-71-3

2,6-dimethylphenyl isonitrile

acetylenedicarboxylic acid diethyl ester
762-21-0

acetylenedicarboxylic acid diethyl ester

diethyl 2-(2,6-dimethylphenylamino)-2,8-dihydro-8-oxo-6-propylpyrimido[2,1-b][1,3]thiazine-3,4-dicarboxylate

diethyl 2-(2,6-dimethylphenylamino)-2,8-dihydro-8-oxo-6-propylpyrimido[2,1-b][1,3]thiazine-3,4-dicarboxylate

Conditions
ConditionsYield
In toluene for 1h; Reflux;93%
propylthiouracil
51-52-5

propylthiouracil

2,6-dimethylphenyl isonitrile
119072-54-7, 2769-71-3

2,6-dimethylphenyl isonitrile

dimethyl acetylenedicarboxylate
762-42-5

dimethyl acetylenedicarboxylate

dimethyl 2-(2,6-dimethylphenylamino)-2,8-dihydro-8-oxo-6-propylpyrimido[2,1-b][1,3]thiazine-3,4-dicarboxylate

dimethyl 2-(2,6-dimethylphenylamino)-2,8-dihydro-8-oxo-6-propylpyrimido[2,1-b][1,3]thiazine-3,4-dicarboxylate

Conditions
ConditionsYield
In toluene for 1h; Reflux;92%
propylthiouracil
51-52-5

propylthiouracil

tert-butylisonitrile
119072-55-8, 7188-38-7

tert-butylisonitrile

chloroacetic acid
79-11-8

chloroacetic acid

acetone
67-64-1

acetone

benzylamine
100-46-9

benzylamine

2-(N-benzyl-2-((6-oxo-4-propyl-1,6-dihydropyrimidin-2-yl)thio)acetamido)-N-(tert-butyl)-2-methylpropanamide
1379463-56-5

2-(N-benzyl-2-((6-oxo-4-propyl-1,6-dihydropyrimidin-2-yl)thio)acetamido)-N-(tert-butyl)-2-methylpropanamide

Conditions
ConditionsYield
Stage #1: propylthiouracil; chloroacetic acid at 20℃; for 0.5h; Ionic liquid;
Stage #2: acetone; benzylamine at 20℃; for 0.25h; Ugi condensation; Ionic liquid;
Stage #3: tert-butylisonitrile at 20℃; for 5h; Ugi condensation; Ionic liquid;
90%
propylthiouracil
51-52-5

propylthiouracil

Cyclohexyl isocyanide
931-53-3

Cyclohexyl isocyanide

chloroacetic acid
79-11-8

chloroacetic acid

acetone
67-64-1

acetone

benzylamine
100-46-9

benzylamine

2-(N-benzyl-2-((6-oxo-4-propyl-1,6-dihydropyrimidin-2-yl)thio)acetamido)-N-cyclohexyl-2-methylpropanamide
1379463-51-0

2-(N-benzyl-2-((6-oxo-4-propyl-1,6-dihydropyrimidin-2-yl)thio)acetamido)-N-cyclohexyl-2-methylpropanamide

Conditions
ConditionsYield
Stage #1: propylthiouracil; chloroacetic acid at 20℃; for 0.5h; Ionic liquid;
Stage #2: acetone; benzylamine at 20℃; for 0.25h; Ugi condensation; Ionic liquid;
Stage #3: Cyclohexyl isocyanide at 20℃; for 5h; Ugi condensation; Ionic liquid;
89%
propylthiouracil
51-52-5

propylthiouracil

Cyclohexyl isocyanide
931-53-3

Cyclohexyl isocyanide

chloroacetic acid
79-11-8

chloroacetic acid

acetone
67-64-1

acetone

1-(cyclohexylamino)-2-methyl-1-oxopropan-2-yl 2-([4-oxo-6-propyl-1,4-dihydropyrimidin-2-yl]thio)acetate

1-(cyclohexylamino)-2-methyl-1-oxopropan-2-yl 2-([4-oxo-6-propyl-1,4-dihydropyrimidin-2-yl]thio)acetate

Conditions
ConditionsYield
With octyl methyl imidazolium bromide for 6h; Heating; Green chemistry;89%
propylthiouracil
51-52-5

propylthiouracil

4-methyl-1,2-dihydroxybenzene
452-86-8

4-methyl-1,2-dihydroxybenzene

2-(4,5-dihydroxy-2-methylphenylthio)-6-propylpyrimidin-4(3H)-one

2-(4,5-dihydroxy-2-methylphenylthio)-6-propylpyrimidin-4(3H)-one

Conditions
ConditionsYield
With laccase from Agaricus bisporus In aq. phosphate buffer; ethanol at 20℃; for 13h; pH=6; Green chemistry; Enzymatic reaction; chemoselective reaction;88%
propylthiouracil
51-52-5

propylthiouracil

Cyclohexyl isocyanide
931-53-3

Cyclohexyl isocyanide

acetylenedicarboxylic acid diethyl ester
762-21-0

acetylenedicarboxylic acid diethyl ester

diethyl 2-(cyclohexylamino)-4,8-dihydro-8-oxo-6-propylpyrimido[2,1-b][1,3]thiazine-3,4-dicarboxylate

diethyl 2-(cyclohexylamino)-4,8-dihydro-8-oxo-6-propylpyrimido[2,1-b][1,3]thiazine-3,4-dicarboxylate

Conditions
ConditionsYield
In toluene for 1h; Reflux;87%
propylthiouracil
51-52-5

propylthiouracil

2-bromo-N-[4-(4-chloro-phenyl)-1,3-thiazol-2-yl]-acetamide
448224-88-2

2-bromo-N-[4-(4-chloro-phenyl)-1,3-thiazol-2-yl]-acetamide

C18H17ClN4O2S2

C18H17ClN4O2S2

Conditions
ConditionsYield
With potassium phosphate; sodium iodide In N,N-dimethyl-formamide at 60℃; for 1h;87%
propylthiouracil
51-52-5

propylthiouracil

Cyclohexyl isocyanide
931-53-3

Cyclohexyl isocyanide

Chloro-phenyl-acetic acid
4755-72-0, 39266-56-3

Chloro-phenyl-acetic acid

acetone
67-64-1

acetone

1-(cyclohexylamino)-2-methyl-1-oxopropan-2-yl 2-([4-oxo-6-propyl-1,4-dihydropyrimidin-2-yl]thio)-2-phenylacetate

1-(cyclohexylamino)-2-methyl-1-oxopropan-2-yl 2-([4-oxo-6-propyl-1,4-dihydropyrimidin-2-yl]thio)-2-phenylacetate

Conditions
ConditionsYield
With octyl methyl imidazolium bromide at 30℃; for 6h; Green chemistry;87%
propylthiouracil
51-52-5

propylthiouracil

6-propyl(1H,3H)pyrimidine-2,4-dione
13345-08-9

6-propyl(1H,3H)pyrimidine-2,4-dione

Conditions
ConditionsYield
With chloroacetic acid In water for 5h; Heating;86%
With chloroacetic acid
With chloroacetic acid Heating;
With chloroacetic acid
propylthiouracil
51-52-5

propylthiouracil

Iodoselane
116302-66-0

Iodoselane

C17H36N2OSSeSi3

C17H36N2OSSeSi3

Conditions
ConditionsYield
With triethylamine In toluene at 20℃; for 0.166667h;85%
propylthiouracil
51-52-5

propylthiouracil

Cyclohexyl isocyanide
931-53-3

Cyclohexyl isocyanide

cyclohexanone
108-94-1

cyclohexanone

chloroacetic acid
79-11-8

chloroacetic acid

benzylamine
100-46-9

benzylamine

1-(N-benzyl-2-((6-oxo-4-propyl-1,6-dihydropyrimidin-2-yl)thio)acetamido)-N-cyclohexylcyclohexanecarboxamide
1379463-54-3

1-(N-benzyl-2-((6-oxo-4-propyl-1,6-dihydropyrimidin-2-yl)thio)acetamido)-N-cyclohexylcyclohexanecarboxamide

Conditions
ConditionsYield
Stage #1: propylthiouracil; chloroacetic acid at 20℃; for 0.5h; Ionic liquid;
Stage #2: cyclohexanone; benzylamine at 20℃; for 0.25h; Ugi condensation; Ionic liquid;
Stage #3: Cyclohexyl isocyanide at 20℃; for 5h; Ugi condensation; Ionic liquid;
85%
propylthiouracil
51-52-5

propylthiouracil

1,1,3,3-tetramethylbutane isonitrile
14542-93-9

1,1,3,3-tetramethylbutane isonitrile

acetylenedicarboxylic acid diethyl ester
762-21-0

acetylenedicarboxylic acid diethyl ester

diethyl 2-(2,4,4-trimethylpentan-2-ylamino)-4,8-dihydro-8-oxo-6-propylpyrimido[2,1-b][1,3]thiazine-3,4-dicarboxylate

diethyl 2-(2,4,4-trimethylpentan-2-ylamino)-4,8-dihydro-8-oxo-6-propylpyrimido[2,1-b][1,3]thiazine-3,4-dicarboxylate

Conditions
ConditionsYield
In toluene for 1h; Reflux;85%
isoquinoline
119-65-3

isoquinoline

propylthiouracil
51-52-5

propylthiouracil

dimethyl acetylenedicarboxylate
762-42-5

dimethyl acetylenedicarboxylate

dimethyl 2-(2-methoxy-2-oxoethylidene)-5-oxo-7-propyl-2H,5H,11b'H-spiro[thiazolo[3,2-a]pyrimidine-3,2'-[1,3]oxazino[2,3-a]isoquinoline]-3',4'-carboxylate

dimethyl 2-(2-methoxy-2-oxoethylidene)-5-oxo-7-propyl-2H,5H,11b'H-spiro[thiazolo[3,2-a]pyrimidine-3,2'-[1,3]oxazino[2,3-a]isoquinoline]-3',4'-carboxylate

Conditions
ConditionsYield
In toluene at 110℃; for 5h;85%
propylthiouracil
51-52-5

propylthiouracil

tert-butylisonitrile
119072-55-8, 7188-38-7

tert-butylisonitrile

chloroacetic acid
79-11-8

chloroacetic acid

acetone
67-64-1

acetone

1-(tert-butylamino)-2-methyl-1-oxopropan-2-yl 2-([4-oxo-6-propyl-1,4-dihydropyrimidin-2-yl]thio)acetate

1-(tert-butylamino)-2-methyl-1-oxopropan-2-yl 2-([4-oxo-6-propyl-1,4-dihydropyrimidin-2-yl]thio)acetate

Conditions
ConditionsYield
With octyl methyl imidazolium bromide at 30℃; for 6h; Green chemistry;85%
propylthiouracil
51-52-5

propylthiouracil

Cyclohexyl isocyanide
931-53-3

Cyclohexyl isocyanide

ethylamine
75-04-7

ethylamine

chloroacetic acid
79-11-8

chloroacetic acid

acetone
67-64-1

acetone

N-cyclohexyl-2-(N-ethyl-2-((6-oxo-4-propyl-1,6-dihydropyrimidin-2-yl)thio)acetamido)-2-methylpropanamide
1379463-49-6

N-cyclohexyl-2-(N-ethyl-2-((6-oxo-4-propyl-1,6-dihydropyrimidin-2-yl)thio)acetamido)-2-methylpropanamide

Conditions
ConditionsYield
Stage #1: propylthiouracil; chloroacetic acid at 20℃; for 0.5h; Ionic liquid;
Stage #2: ethylamine; acetone at 20℃; for 0.25h; Ugi condensation; Ionic liquid;
Stage #3: Cyclohexyl isocyanide at 20℃; for 5h; Ugi condensation; Ionic liquid;
83%
propylthiouracil
51-52-5

propylthiouracil

Cyclohexyl isocyanide
931-53-3

Cyclohexyl isocyanide

chloroacetic acid
79-11-8

chloroacetic acid

pentan-3-one
96-22-0

pentan-3-one

3-(cyclohexylcarbamoyl)pentan-3-yl 2-([4-oxo-6-propyl-1,4-dihydropyrimidin-2-yl]thio)acetate

3-(cyclohexylcarbamoyl)pentan-3-yl 2-([4-oxo-6-propyl-1,4-dihydropyrimidin-2-yl]thio)acetate

Conditions
ConditionsYield
With octyl methyl imidazolium bromide at 30℃; for 6h; Green chemistry;83%
propylthiouracil
51-52-5

propylthiouracil

Cyclohexyl isocyanide
931-53-3

Cyclohexyl isocyanide

Chloro-phenyl-acetic acid
4755-72-0, 39266-56-3

Chloro-phenyl-acetic acid

pentan-3-one
96-22-0

pentan-3-one

3-(cyclohexylcarbamoyl)pentan-3-yl 2-([4-oxo-6-propyl-1,4-dihydropyrimidin-2-yl]thio)-2-phenylacetate

3-(cyclohexylcarbamoyl)pentan-3-yl 2-([4-oxo-6-propyl-1,4-dihydropyrimidin-2-yl]thio)-2-phenylacetate

Conditions
ConditionsYield
With octyl methyl imidazolium bromide at 30℃; for 6h; Green chemistry;83%
propylthiouracil
51-52-5

propylthiouracil

methyl iodide
74-88-4

methyl iodide

2-(methylthio)-6-propylpyrimidin-4(3H)-one
5751-17-7

2-(methylthio)-6-propylpyrimidin-4(3H)-one

Conditions
ConditionsYield
With sodium hydroxide In water at 20 - 40℃; for 4h;82%
With potassium hydroxide
With sodium hydroxide In water at 20℃;
propylthiouracil
51-52-5

propylthiouracil

4-bromo-trans-crotonic acid ethyl ester
37746-78-4

4-bromo-trans-crotonic acid ethyl ester

(5-oxo-7-propyl-2,3-dihydro-5H-thiazolo[3,2-a]pyrimidin-3-yl)-acetic acid ethyl ester

(5-oxo-7-propyl-2,3-dihydro-5H-thiazolo[3,2-a]pyrimidin-3-yl)-acetic acid ethyl ester

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 1h;82%
propylthiouracil
51-52-5

propylthiouracil

Cyclohexyl isocyanide
931-53-3

Cyclohexyl isocyanide

acetone
67-64-1

acetone

(R,S)-2-chloropropionic acid
598-78-7

(R,S)-2-chloropropionic acid

1-(cyclohexylamino)-2-methyl-1-oxopropan-2-yl 2-([4-oxo-6-propyl-1,4-dihydropyrimidin-2-yl]thio)propanoate

1-(cyclohexylamino)-2-methyl-1-oxopropan-2-yl 2-([4-oxo-6-propyl-1,4-dihydropyrimidin-2-yl]thio)propanoate

Conditions
ConditionsYield
With octyl methyl imidazolium bromide at 30℃; for 6h; Green chemistry;82%
propylthiouracil
51-52-5

propylthiouracil

tert-butylisonitrile
119072-55-8, 7188-38-7

tert-butylisonitrile

Chloro-phenyl-acetic acid
4755-72-0, 39266-56-3

Chloro-phenyl-acetic acid

acetone
67-64-1

acetone

1-(tert-butylamino)-2-methyl-1-oxopropan-2-yl 2-([4-oxo-6-propyl-1,4-dihydropyrimidin-2-yl]thio)-2-phenylacetate

1-(tert-butylamino)-2-methyl-1-oxopropan-2-yl 2-([4-oxo-6-propyl-1,4-dihydropyrimidin-2-yl]thio)-2-phenylacetate

Conditions
ConditionsYield
With octyl methyl imidazolium bromide at 30℃; for 6h; Green chemistry;81%
propylthiouracil
51-52-5

propylthiouracil

3,3-dichloroallyl halide

3,3-dichloroallyl halide

C10H12Cl2N2OS

C10H12Cl2N2OS

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide81%
propylthiouracil
51-52-5

propylthiouracil

hydroquinone
123-31-9

hydroquinone

2-(2,5-dihydroxyphenylsulfanyl)-6-propyl-1H-pyrimidin-4-one
1611453-74-7

2-(2,5-dihydroxyphenylsulfanyl)-6-propyl-1H-pyrimidin-4-one

Conditions
ConditionsYield
In aq. phosphate buffer; water; N,N-dimethyl-formamide at 25℃; pH=6; Michael Addition; Electrolysis;80%
isoquinoline
119-65-3

isoquinoline

propylthiouracil
51-52-5

propylthiouracil

acetylenedicarboxylic acid diethyl ester
762-21-0

acetylenedicarboxylic acid diethyl ester

diethyl 2-(2-ethoxy-2-oxoethylidene)-5-oxo-7-propyl-2H,5H,11b'H-spiro[thiazolo[3,2-a]pyrimidine-3,2'-[1,3]oxazino[2,3-a]isoquinoline]-3',4'-carboxylate

diethyl 2-(2-ethoxy-2-oxoethylidene)-5-oxo-7-propyl-2H,5H,11b'H-spiro[thiazolo[3,2-a]pyrimidine-3,2'-[1,3]oxazino[2,3-a]isoquinoline]-3',4'-carboxylate

Conditions
ConditionsYield
In toluene at 110℃; for 5h;80%
propylthiouracil
51-52-5

propylthiouracil

tert-butylisonitrile
119072-55-8, 7188-38-7

tert-butylisonitrile

ethylamine
75-04-7

ethylamine

chloroacetic acid
79-11-8

chloroacetic acid

acetone
67-64-1

acetone

N-(tert-butyl)-2-(N-ethyl-2-((6-oxo-4-propyl-1,6-dihydropyrimidin-2-yl)thio)acetamido)-2-methylpropanamide
1379463-57-6

N-(tert-butyl)-2-(N-ethyl-2-((6-oxo-4-propyl-1,6-dihydropyrimidin-2-yl)thio)acetamido)-2-methylpropanamide

Conditions
ConditionsYield
Stage #1: propylthiouracil; chloroacetic acid at 20℃; for 0.5h; Ionic liquid;
Stage #2: ethylamine; acetone at 20℃; for 0.25h; Ugi condensation; Ionic liquid;
Stage #3: tert-butylisonitrile at 20℃; for 5h; Ugi condensation; Ionic liquid;
79%
propylthiouracil
51-52-5

propylthiouracil

methyl 5-deoxy-5-iodo-2,3-isopropylidene-β-D-ribofuranoside
38838-06-1

methyl 5-deoxy-5-iodo-2,3-isopropylidene-β-D-ribofuranoside

methyl 5-deoxy-2,3-O-isopropylidene-5-(6-propyluracil-2-yl)thio-β-D-ribofuranoside
676557-71-4

methyl 5-deoxy-2,3-O-isopropylidene-5-(6-propyluracil-2-yl)thio-β-D-ribofuranoside

Conditions
ConditionsYield
With sodium hydroxide In ethanol; water at 60℃; for 1h;78%

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