2827-46-5

Basic information

• Product Name: N,N',N''-trimethyl-1,3,5-triazine-2,4,6-triamine
• Synonyms: N,N',N''-trimethyl-1,3,5-triazine-2,4,6-triamine;2,4,6-trimethylmelamine;1,3,5-Triazine-2,4,6-triaMine, N,N',N''-triMethyl-
• CAS NO: 2827-46-5
• Molecular Formula: C₆H₁₂N₆
• Molecular Weight: 168.19968
• EINECS: 220-588-4
• Mol File: 2827-46-5.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 287.14°C (rough estimate)
• Flash Point: 162.4°C
• Appearance: /
• Density: 1.2715 (rough estimate)
• Refractive Index: 1.8300 (estimate)
• CAS DataBase Reference: N,N',N''-trimethyl-1,3,5-triazine-2,4,6-triamine(CAS DataBase Reference)
• NIST Chemistry Reference: N,N',N''-trimethyl-1,3,5-triazine-2,4,6-triamine(2827-46-5)
• EPA Substance Registry System: N,N',N''-trimethyl-1,3,5-triazine-2,4,6-triamine(2827-46-5)

Safety Data

• Hazardous Substances Data: 2827-46-5(Hazardous Substances Data)

Usage

General Description

N,N',N''-trimethyl-1,3,5-triazine-2,4,6-triamine is a chemical compound that belongs to the class of organic compounds known as 1,3,5-triazines. These are compounds containing a triazine ring, which is a six-membered aromatic ring made up of three nitrogen atoms and three carbon atoms in alternating positions. The exact structure of N,N',N''-trimethyl-1,3,5-triazine-2,4,6-triamine is characterized by the addition of three methyl groups (each containing one carbon and three hydrogen atoms) bound to the nitrogen atoms of the triazine ring. This chemical is not known to have any common applications and its toxicity, reactivity, or potential uses in industry or biomedical research have not been widely studied.

Upstream product

• 108-77-0 1,3,5-trichloro-2,4,6-triazine 
• 593-51-1 methylamine hydrochloride 
• 67-56-1 methanol 
• 108-78-1 2,4,6-triamino-s-triazine 
• 64124-21-6 (1,3,5-triazine-2,4,6-triyl)tris(methylazanediyl)trimethanol 
• 95-48-7 ortho-cresol 
• 74-89-5 methylamine 
• 2911-36-6 N²,N⁴-dimethyl-2,4-diamino-6-chloro-[1,3,5]triazine 
• 6542-67-2 2,4,6-tris(trichloromethyl)-s-triazine 
• 5759-58-0 2,4,6-tris(methylthio)-1,3,5-triazine 

Downstream Products

• 108-80-5 isocyanuric acid 
• 74-89-5 methylamine 
• 1307264-09-0 2,2',2''-(1,3,5-triazine-2,4,6-triyl)tris(methylazanediyl)-tris(methylene)triphenol 
• 1307264-08-9 C₁₄H₂₀N₆O 
• 1307264-07-8 C₂₂H₂₈N₆O₂ 
• 1307264-05-6 C₃₀H₃₆N₆O₃ 
• 177498-85-0 N-Benzyloxy-N-(4-{[(4,6-bis-{[4-(acetyl-benzyloxy-amino)-butoxymethyl]-methyl-amino}-[1,3,5]triazin-2-yl)-methyl-amino]-methoxy}-butyl)-acetamide 
• 177498-86-1 N-Benzyloxy-N-(3-{[(4,6-bis-{[3-(acetyl-benzyloxy-amino)-propoxymethyl]-methyl-amino}-[1,3,5]triazin-2-yl)-methyl-amino]-methoxy}-propyl)-acetamide 
• 64124-21-6 (1,3,5-triazine-2,4,6-triyl)tris(methylazanediyl)trimethanol 

Relevant articles and documents

METHOD FOR ALKYLATING AN AMINO COMPOUND

The invention relates to a method for alkylating an amino compound, characterized in that at least one triazine derivative of general formula (I) or at least one urea or urea derivative of the general formula (II), (II), wherein ? R4 and R5 mean independently from each other Q1 or a moiety of the formula R6-N-R7 or R8-N-R9 bound with its central nitrogen atom to the triazine ring of the structure of formula (I), whereat - Q1 means a linear or branched C1-C30-alkyl or a cyclic substituent in form of a C5-C20-cycloalkyl, a C5-C20-aryl, a C1-C20-alkylsubstituted C5-C20-aryl or an amide of a cyclic unsaturated carboxylic acid, whereat the C1-C30-alkyl or the cyclic substituent can be interrupted by one or multiple oxygen atoms, sulphur atoms, substituted nitrogen atoms and/or by one or multiple groups of the type –C(O)O-,-OC(O)-,-C(O)- and/or –OC(O)O-, ? R1, R2, R3, R6, R7, R8 and R9 mean independently from each other H, linear or branched C1-C20-alkyl, C5-C20-cyclo alkyl, C5-C20-aryl, C1-C20-alkylsubstituted C5-C20-aryl, which in each case can be interrupted by one or multiple oxygen atoms, sulphur atoms and/or substituted nitrogen atoms and/or by one or multiple groups of the type –C(O)O-, - OC(O)-, -C(O)- and/or –OC(O) O- and/or can be functionalized by one or multiple hydroxyl groups and/or mercapto groups, and ? X means O or S, is reacted with at least one alcohol of the general formula (III) R10-OH wherein R10 means a linear or branched C1-C20-alkyl, C5-C20-cycloalkyl, or C1-C20- alkylsubstituted C5-C20-aryl, which can be in each case interrupted by one or multiple oxygen atoms, sulphur atoms, substituted nitrogen atoms and/or by one or multiple groups of the type –C(O)O-, -OC(O)-, -C(O)- and/or –OC(O)O- and/or can be functionalized by one or multiple hydroxyl groups and/or mercapto groups, wherein the reaction is carried out in the presence of at least one Ruthenate of the general formula (IV) Mn(RuO4) and/or at least one Perruthenate of the general formula (V) M(RuO4)n wherein the cation M is selected from a group comprising an alkali, earth alkali or substituted or non-substituted ammonium cation.

Method for modifying a triazine compound

The present invention relates to a method for modifying a triazine compound comprising the steps of a) Providing at least one triazine compound of the general formulae (I) wherein - R1 and R2 mean independently from each other Q1 or a moiety of the formula R3-N-R4 or R5-N-R6 bound with its central nitrogen atom to the triazine ring of the structure of formula (I), whereat - Q1 means H, hydroxyl, a linear or branched C1-C30-alkyl or a cyclic substituent in form of a C5-C20-cycloalkyl, a C5-C20-aryl, a C1-C20-alkylsubstituted C5-C20-aryl, wherein in each case one or multiple carbon atoms can be substituted by one or multiple oxygen atoms, sulphur atoms, substituted nitrogen atoms and/or by one or multiple groups of the type -C(O)O-,-OC(O)-,-C(O)- and/or -OC(O)O-, and/or can be functionalized by one or multiple hydroxyl groups and/or mercapto groups, - R3, R4, R5 and R6 mean independently from each other H, linear or branched C1-C20-alkyl, C5-C20-cyclo alkyl, C5-C20-aryl, C1-C20-alkylsubstituted C5-C20-aryl, wherein in each case one or multiple carbon atoms can be substituted by one or multiple oxygen atoms, sulphur atoms and/or substituted nitrogen atoms and/or by one or multiple groups of the type -C(O)O-, -OC(O)-, -C(O)- and/or -OC(O)O-, and/or can be functionalized by one or multiple hydroxyl groups and/or mercapto groups; or an amide of a carboxylic acid or an imide of a cyclic dicarboxylic acid, and b) Reacting said aminotriazine of the general formulae (I) with at least one ammonium salt of the general formulae (II) ???????? [(R7R8H2N+]nXn- wherein R7 and R8 linear or branched C1-C20-alkyl, C5-C20-cycloalkyl, or C1-C20-alkylsubstituted C5-C20-aryl or cyclic amines, or wherein R7 and R8 together form an alkyl ring, wherein in each case one or multiple carbon atoms can be substituted by one or multiple oxygen atoms, sulphur atoms and/or substituted nitrogen atoms and/or by one or multiple groups of the type -C(O)O-, -OC(O)-, -C(O)- and/or -OC(O) O- and/or can be functionalized by one or multiple hydroxyl groups and/or mercapto groups, and wherein R7 and R8 can be the same or different; wherein Xn- is an anion of an organic or inorganic acid, and wherein n ≥1, in particular 1, 2 or 3, and c) wherein the reaction takes place in a salt melt of the at least one ammonium salt of the general formuale (II).

Synthesis and cytotoxic activity of trisubstituted-1,3,5-triazines

1,3,5-Triazine derivatives were screened for phototoxicity as well as the cytotoxic activities against leukemia and adenocarcinoma derived cell lines in comparison to the normal human keratinocytes. A simple and environmentally friendly procedure has been developed for the synthesis of 1,3,5-triazine derivatives under microwave irradiation in the presence of a HY zeolite. The catalyst can be recovered and reused. Thus, the procedure provides a simple and green synthetic methodology under environmentally friendly conditions. Structure-activity relationships between the chemical structures and antimycobacterial and photosynthesis-inhibiting activity of the evaluated compounds are also discussed.