28280-37-7

Usage

Uses

Used in Organic Synthesis:
2,4-difluoro-1-(4-nitrophenoxy)benzene is utilized as a key intermediate in organic synthesis, contributing to the creation of a wide range of chemical products. Its presence in the synthesis process is crucial for the formation of complex organic molecules, which can be tailored for specific applications.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2,4-difluoro-1-(4-nitrophenoxy)benzene is employed as a building block for the development of new drugs. Its unique structure allows for the design of molecules with specific therapeutic properties, making it a valuable asset in the discovery and creation of novel pharmaceutical compounds.
Used in Agrochemical Production:
2,4-difluoro-1-(4-nitrophenoxy)benzene is also a potential intermediate in the production of agrochemicals. Its incorporation into these products can enhance their effectiveness in agricultural applications, such as pest control and crop protection.
Used in Dye Manufacturing:
2,4-difluoro-1-(4-nitrophenoxy)benzene is utilized in the manufacturing of dyes, where its unique properties contribute to the development of dyes with specific color characteristics and stability. Its use in this industry is instrumental in creating dyes that meet the demands of various applications, including textiles, plastics, and printing inks.
Used in Research and Development:
2,4-difluoro-1-(4-nitrophenoxy)benzene's unique structure and properties make it a valuable tool for research and development in the fields of chemistry and material science. It serves as a platform for exploring new chemical reactions, understanding molecular interactions, and developing innovative materials with tailored properties for various applications.

InChI:InChI=1/C12H7F2NO3/c13-8-1-6-12(11(14)7-8)18-10-4-2-9(3-5-10)15(16)17/h1-7H

Upstream product

• 367-27-1 2,4-difluorophenol 
• 350-46-9 4-Fluoronitrobenzene 
• 100-00-5 4-chlorobenzonitrile 

Downstream Products

• 286932-63-6 4-(2,4-difluorophenoxy)aniline 

Relevant academic research and scientific papers

Chemical validation of a druggable site on Hsp27/HSPB1 using in silico solvent mapping and biophysical methods

Destabilizing mutations in small heat shock proteins (sHsps) are linked to multiple diseases; however, sHsps are conformationally dynamic, lack enzymatic function and have no endogenous chemical ligands. These factors render sHsps as classically “undruggable” targets and make it particularly challenging to identify molecules that might bind and stabilize them. To explore potential solutions, we designed a multi-pronged screening workflow involving a combination of computational and biophysical ligand-discovery platforms. Using the core domain of the sHsp family member Hsp27/HSPB1 (Hsp27c) as a target, we applied mixed solvent molecular dynamics (MixMD) to predict three possible binding sites, which we confirmed using NMR-based solvent mapping. Using this knowledge, we then used NMR spectroscopy to carry out a fragment-based drug discovery (FBDD) screen, ultimately identifying two fragments that bind to one of these sites. A medicinal chemistry effort improved the affinity of one fragment by ~50-fold (16 μM), while maintaining good ligand efficiency (~0.32 kcal/mol/non-hydrogen atom). Finally, we found that binding to this site partially restored the stability of disease-associated Hsp27 variants, in a redox-dependent manner. Together, these experiments suggest a new and unexpected binding site on Hsp27, which might be exploited to build chemical probes.

AGRICULTURAL CHEMICALS

The present invention relates to picolinic acid derivatives that are useful in treating fungal diseases ofplants.

A focused library of protein tyrosine phosphatase inhibitors

Protein tyrosine phosphatases such as PTP1B and YopH are potential targets for the development of therapeutic agents against a variety of pathological conditions including diabetes, obesity, and infection by the bacterium Yersinia pestis. A focused library of bidentate α-ketoacid-based inhibitors has been screened against several tyrosine phosphatases. Compound 2a has IC 50 values of 43 and 220 nM against YopH and PTP1B, respectively, and shows a 30-fold selectivity for PTP1B over the closely related phosphatase TCPTP.

Potentiators of glutamate receptors

The present invention relates to potentiators of metabotropic glutamate receptor function and specifically provides compounds of formula I, compositions thereof and methods of using the same.