28292-84-4

Upstream product

• 28557-00-8 phenylzinc chloride 
• 647016-68-0 3-bromo-5-phenylisothiazole-4-carbonitrile 
• 915395-62-9 3-iodo-5-phenylisothiazole-4-carbonitrile 
• 98-80-6 phenylboronic acid 
• 960-16-7 tributylphenylstannane 
• 2168-78-7 methyl dithiobenzoate 
• 100-47-0 benzonitrile 
• 75-05-8 acetonitrile 

Downstream Products

• 942227-96-5 3,5-diphenylisothiazole-4-carboxamide 
• 101727-68-8 3,5-diphenyl-1H-pyrazole-4-carbonitrile 
• 35529-46-5 3,4,5-Triphenylisothiazole 
• 942227-97-6 3-chloro-5-phenylisothiazole-4-carboxylic acidY 
• 942228-02-6 4-iodo-3,5-diphenylisothiazole 
• 942228-01-5 4-amino-3,5-diphenylisothiazole 
• 942228-00-4 methyl 3,5-diphenylisothiazole-4-carbamate 
• 3920-15-8 3,5-diphenylisothiazole 

Relevant academic research and scientific papers

New regiospecific isothiazole C-C coupling chemistry

Regioselective palladium catalysed coupling reactions are achieved in good to high yields, starting from either 3,5-dichloro- or 3,5-dibromoisothiazole-4-carbonitriles 1 and 2, providing 3-halo-5-(hetero/aryl, alkenyl and alkynyl)isothiazoles 3, 4, 6-9 fr

ELEKTROCHEMISCHE OXIDATION VON DITHIOCARBONSAEUREESTERN ZU ISOTHIAZOLEN

Electrolysis of alkyl arenedithioates 1 in acetonitrile with benzyl-triethyl-ammonium chloride as supporting electrolyte yields 5-aryl-4-cyano-3-methyl-isothiazoles 4.A reaction path is discussed according to which the dithioesters 1 are chlorinated at the anode and subsequently react with 3-iminobutyronitrile (6), generated at the cathode, to form the isothiazoles 4.