283589-04-8

Basic information

• Product Name: (S)-1-Benzyl-3-broMo-piperidine
• Synonyms: (S)-1-Benzyl-3-broMo-piperidine
• CAS NO: 283589-04-8
• Molecular Formula: C12H16BrN
• Molecular Weight: 254.16614
• Mol File: 283589-04-8.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 300.6±35.0 °C(Predicted)
• Appearance: /
• Density: 1.336±0.06 g/cm3(Predicted)
• PKA: 7.97±0.10(Predicted)
• CAS DataBase Reference: (S)-1-Benzyl-3-broMo-piperidine(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-1-Benzyl-3-broMo-piperidine(283589-04-8)
• EPA Substance Registry System: (S)-1-Benzyl-3-broMo-piperidine(283589-04-8)

Safety Data

• Hazardous Substances Data: 283589-04-8(Hazardous Substances Data)

Upstream product

• 1119-51-3 bromopentene 
• 100-46-9 benzylamine 
• 54436-58-7 N-benzylpent-4-en-1-amine 
• 285-76-7 1-azabicyclo[3.1.0]hexane 
• 100-39-0 benzyl bromide 
• 53912-80-4 (S)-N-benzylprolinol 

Relevant articles and documents

Regioselective copper(II)-mediated bromoamination of unfunctionalized olefins: An efficient route to N-heterocyclic compounds

Bromoamination of unfunctionalized olefins was realized under mild conditions using copper(II) bromide (CuBr2) as both reaction promoter and bromine source. The reactions could be carried out under open air at ambient temperature, and both N-alkylated and N-tosylated substrates could be converted to the corresponding N-heterocyclic compounds in high regioselectivity and good isolated yields. A variety of biologically important structures could be obtained via subsequent nucleophilic substitution reactions.

Synthesis and reaction of 1-azabicyclo[3.1.0]hexane

The effective formation of 1-azabicyclo[3.1.0]hexane (5) by treatment of 2-(bromomethyl)pyrrolidine hydrobromide (4) with n-BuLi was established, with the reaction occurring by a rational reaction pathway via the open chain transition state 8 based on int