2845-29-6Relevant academic research and scientific papers
Catalytic enantioselective aldol reaction to ketones
Oisaki, Kounosuke,Zhao, Dongbo,Kanai, Motomu,Shibasaki, Masakatsu
, p. 7164 - 7165 (2006)
An enantioselective aldol reaction between ketones and ketene silyl acetals is described using CuF-chiral phosphine as a catalyst. The key for high enantioselectivity was the development of a novel ligand derived from Taniaphos combined with the unique ac
Asymmetric Mukaiyama aldol reaction of nonactivated ketones catalyzed by allo-threonine-derived oxazaborolidinone
Adachi, Shinya,Harada, Toshiro
supporting information; experimental part, p. 4991 - 5001 (2009/05/31)
(Chemical Equation Presented) Asymmetric Mukaiyama aldol reaction of nonactivated ketones is realized for the first time by using an oxazaborolidinone catalyst derived from O-benzoyl-N-tosyl-allo-threonine. By employing a dimethylsilyl ketene S,O-acetal as a nucleophile, a variety of acetophenone derivatives afford the corresponding tertiary β-hydroxy carbonyl compounds with high enantioselectivity up to 98% ee.
Catalytic, enantioselective aldol additions to ketones
Denmark, Scott E.,Fan, Yu
, p. 4233 - 4235 (2007/10/03)
Catalytic, enantioselective additions of a trichlorosilyl ketene acetal to ketones have been demonstrated. The trichlorosilyl enolate of methyl acetate undergoes a rapid and high-yielding aldol addition to a wide range of ketones (aromatic, olefinic, acet
