2845-43-4Relevant academic research and scientific papers
A NOVEL AMINOMETHYLATION OF SILYL ENOL ETHERS WITH AMINOMETHYL ETHERS CATALYZED BY IODOTRIMETHYLSILANE OR TRIMETHYLSILYL TRIFLUOROMETHANESULFONATE
Hosomi, Akira,Iijima, Susumu,Sakurai, Hideki
, p. 547 - 550 (1982)
The iodotrimethylsilane-catalyzed reaction of silyl enol ethers with aminomethyl ethers in acetonitrile gives aminomethylation products of the corresponding ketones readily.The reaction can also be catalyzed by trimethylsilyl trifluoromethanesulfonate in dichloromethane.
Fe-catalyzed bisphosphorylation of amino-2-en-1-ones with trialkyl Phosphites
Guo, Shengmei,Jie, Kun,Huang, Ling,Zhang, Zhebin,Wang, Yufeng,Fu, Zhengjiang,Cai, Hu
supporting information, p. 1090 - 1094 (2019/05/27)
A facile bisphosphorylation of amino-2-en-1-ones with trialkyl phosphites mediated by iron is developed. The reaction is considered to go through two Michael addition progresses. A variety of amino-2-en-1-ones are bisphosphorylated in high yields with functional group tolerance. In addition, the protocol of introduction of two different phosphates into one molecule is successful through a cascade reaction.
Dibromomethane as one-carbon source in organic synthesis: Microwave-accelerated α-methylenation of ketones with dibromomethane and diethylamine
Hon, Yung-Son,Hsu, Tzyy-Rong,Chen, Chun-Yan,Lin, Yi-Hui,Chang, Fong-Jong,Hsieh, Cheng-Han,Szu, Ping-Hui
, p. 1509 - 1520 (2007/10/03)
The reactivity of aryl alkyl ketone with a preheated mixture of dibromomethane and diethylamine is poor and gives an α-methylenation product in very low yield even under refluxing condition. It can be accelerated dramatically by microwave irradiation. Under microwave condition, the cyclic 1,3-dicarbonyls, aryl alkyl ketones, heteroaryl alkyl ketones and acyclic benzyl ketone give α-methylenation products in modest to good yields.
Solvent-free three-component condensation reaction of aromatic ketones with aliphatic amines and formaldehyde
Mojtahedi,Saidi,Sharifi,Noushabadi,Bolourtchian
, p. 380 - 381 (2007/10/03)
A solvent-free procedure for the synthesis of several 1-aryl-2-(dialkylaminomethyl)-prop-2-en-1-ones 3 (a-e) and 4 (a-e) is reported. Reaction of arylmethyl ketones with formaldehyde and dialkylamines, such as diethyl- or dibutylamines at room temperature in silica gel produce 3 and 4 with moderate yields.
