28478-27-5

Upstream product

• 110-91-8 morpholine 
• 100-42-5 styrene 

Downstream Products

• 70735-64-7 4-[N-(4-chloro-phenyl)-2-phenyl-propionimidoyl]-morpholine 
• 70726-32-8 5-chloro-2-methyl-3-morpholin-4-yl-2-phenyl-2,3-dihydro-indole 
• 70704-24-4 4-[N-(4-cyano-phenyl)-2-phenyl-propionimidoyl]-morpholine 
• 61253-76-7 4-(5-methyl-1,2,5-triphenyl-4,5-dihydro-1H-imidazol-4-yl)-morpholine 
• 4394-85-8 4-morpholinecarboxaldehyde 
• 98-86-2 acetophenone 
• 54968-72-8 4-(2-methyl-2-phenyl-cyclopropyl)-morpholine 
• 110-91-8 morpholine 
• 1468-28-6 4-benzoylmorpholine 
• 34713-70-7 2-Phenylpropanal 
• 70729-31-6 2-chloro-2-phenylpropanal 
• 30924-69-7 N-(4-nitro-benzenesulfonyl)-benzamidine 
• 113676-42-9 4-[5-Methyl-1-(4-nitro-benzenesulfonyl)-2,5-diphenyl-4,5-dihydro-1H-imidazol-4-yl]-morpholine 
• 4115-16-6 N-[(4-methylphenyl)sulfonyl]benzenecarboximidamide 

Relevant academic research and scientific papers

HYDROAMINOMETHYLATION OF OLEFINS

The present invention relates to a method comprising the step of contacting under hydroaminomethylation conditions, an olefin, an amine, a rhodium-phosphorous ligand, and synthesis gas (syngas). In particular, it has been discovered that, under some circumstances, a neutral rhodium-monodentate phosphite ligand is prescribed. The invention provides a simple way of making, in high yields and regiospecificity, a variety of products, including pharmacologically active products such as ibutilide, terfenadine, and fexofenadine, and derivatives thereof.