2848-25-1

Basic information

• Product Name: 2-hydroxyphenyl acetate
• Synonyms: 1,2-benzenediol, monoacetate; Catechol, acetate
• CAS NO: 2848-25-1
• Molecular Formula: C₈H₈O₃
• Molecular Weight: 152.1473
• Mol File: 2848-25-1.mol
• Article Data: 25

Chemical Properties

• Boiling Point: 242.3°C at 760 mmHg
• Flash Point: 102.7°C
• Density: 1.212g/cm³
• Vapor Pressure: 0.022mmHg at 25°C
• Refractive Index: 1.541
• CAS DataBase Reference: 2-hydroxyphenyl acetate(CAS DataBase Reference)
• NIST Chemistry Reference: 2-hydroxyphenyl acetate(2848-25-1)
• EPA Substance Registry System: 2-hydroxyphenyl acetate(2848-25-1)

Safety Data

• Hazardous Substances Data: 2848-25-1(Hazardous Substances Data)

Upstream product

• 108-24-7 acetic anhydride 
• 120-80-9 benzene-1,2-diol 
• 110-86-1 pyridine 
• 6255-58-9 2-oxo-1,3,2-benzodioxathiolene 
• 64-19-7 acetic acid 
• 75-36-5 acetyl chloride 
• 14046-39-0 2-Methyl-1,3-benzodioxole 
• 7555-18-2 2-Ethoxy-2-methylbenzo-1,3-dioxolane 
• 546-67-8 lead(IV) tetraacetate 
• 74024-80-9 2-pentyl-1,3-benzodioxole 
• 110851-22-4 1,10-Dimethyl-2,9,11,12,13-pentaoxa-tricyclo[8.2.1.0^3,8]trideca-3,5,7-triene 
• 65109-75-3 N-(phenoxy)-4-methylbenzenesulfonamide 
• 36887-70-4 2,2-di-n-butyl-1,3,2-benzodioxastannole 
• 4442-67-5 2-chloro-1,3,2-benzodioxa-arsole 

Downstream Products

• 114106-30-8 3-(3-Acetoxy-2-hydroxy-phenyl)-3-(2-methoxycarbonyl-ethylsulfanyl)-propionic acid methyl ester 
• 1000787-02-9 C₂₀H₁₈ClNO₃S 
• 16643-37-1 salicin pentaacetate 
• 57322-56-2 2-hydroxyphenyl-3-oxobutanoate 
• 3316-09-4 1,2-dihydroxy-4-nitrobenzene 
• 6665-98-1 3-nitrobenzene-1,2-diol 
• 2442-31-1 8-hydroxycoumarin 
• 798557-95-6 7-[2-(3-methoxycarbonylpropoxy)phenoxy]heptanoic acid methyl ester 

Relevant articles and documents

Experimental and computational studies on the [3,3]- and [3,5]-sigmatropic rearrangements of acetoxycyclohexadienones: A non-ionic mechanism for acyl migration

Flash vacuum pyrolysis studies of substituted 6-acetoxy-2,4- cyclohexadienones (3 and 10) from 300 to 500 C provide strong experimental evidence that direct [3,5]-sigmatropic rearrangements in these molecules are favored over the more familiar [3,3]-sigma

Para -Selective hydroxylation of alkyl aryl ethers

para-Selective hydroxylation of alkyl aryl ethers is established, which proceeds with a ruthenium(ii) catalyst, hypervalent iodine(iii) and trifluoroacetic anhydride via a radical mechanism. This protocol tolerates a wide scope of substrates and provides a facile and efficient method for preparing clinical drugs monobenzone and pramocaine on a gram scale.

Utilization of the inherent nucleophile for regioselective O-acylation of polyphenols via an intermolecular cooperative transesterification

A green and efficient method for regioselective O-acylation of polyphenols has been developed. The acylation can be carried out in potassium carbonate/dimethyl sulphoxide system by utilizing the ‘inherent nucleophile’ via an intermolecular cooperative transesterification under mild condition. This method shows particular advantage in regioselective acylation of polyphenols bearing 2′,4′-dihydroxyacetophenone moiety and can be extended to the synthesis of mono or multiple acetates of polyphenols without this moiety in good yields. Compared with other reported approaches, this method is endowed with atom economy and is more environment-friendly for avoiding the use of any metal-based catalysts.