28529-71-7

Usage

Uses

Used in Medicinal Chemistry:
2-AMINOMETHYL-ADAMANTAN-2-OL is used as a building block for the synthesis of new drugs due to its unique adamantane-based structure, which may contribute to the development of compounds with enhanced stability and bioactivity.
Used in Pharmaceutical Development:
2-AMINOMETHYL-ADAMANTAN-2-OL is used as a potential drug candidate for various therapeutic purposes, leveraging its chemical properties to target specific biological pathways or diseases. Its application in this field is still in the exploratory stage, with ongoing research aimed at uncovering its full potential.
Used in Drug Design and Synthesis:
In the pharmaceutical industry, 2-AMINOMETHYL-ADAMANTAN-2-OL is used as a key component in drug design and synthesis, where its adamantane ring and functional groups can be strategically modified to create novel therapeutic agents with improved pharmacokinetic and pharmacodynamic profiles.

InChI:InChI=1/C11H19NO/c12-6-11(13)9-2-7-1-8(4-9)5-10(11)3-7/h7-10,13H,1-6,12H2

Upstream product

• 700-58-3 2-Adamantanone 
• 7677-24-9 trimethylsilyl cyanide 
• 24779-92-8 2-cyanoadamantan-2-ol 

Downstream Products

• 1059192-32-3 N-(2-hydroxy-2-tricyclo[3.3.1.1.(3,7)]decylmethyl)benzamide 
• 104822-34-6 adamantane-spiro-5-<(N-m-nitrobenzoyl)oxazolidin-2-one> 
• 24669-56-5 homoadamantan-4-one 
• 104822-33-5 adamantane-spiro-5-oxazolidin-2-one 

Relevant academic research and scientific papers

Colloid and nanosized catalysts in organic synthesis: XII. Hydrogenation of carbonitriles catalyzed by nickel nanoparticles

Hydrogenation of carbonitriles catalyzed by nickel nanoparticles in isopropanol proceeds under atmospheric pressure of hydrogen within 6-15 h to yield mainly secondary amines. Hydrogenation of α-aminonitriles results in reductive decyanation. β-Aminonitriles undergo hydrogenolysis at the nitrogen-carbon bond.

Condensation of adamantanone with methylene-active compounds

A convenient method was developed for the preparation of potentially bioactive substances with 2-adamantyl radical and of intermediates for their synthesis. Condensation of adamantanone with methylene-active compounds was performed, and the reaction features were determined.

Design and synthesis of bioactive adamantanaminoalcohols and adamantanamines

Adamantanamines 16, 18, 21, 24, 27, 28, 30, 32, 35, 36, 37, 40, 46 and 48 were synthesized and tested for anti-influenza A virus and trypanocidal activity. The stereoelectronic requirements for optimal antiviral and trypanocidal potency were investigated.

PYRIDAZINONE DERIVATIVES AND USE THEREOF AS P2X7 RECEPTOR INHIBITORS

Novel pyridazinone compounds of formula (I), which inhibit the purinergic P2X7 receptor and are useful for prevention, therapy and improvement of inflammatory and immunological diseases.

Conformationally constrained adamantaneoxazolines of pharmacological interest

New conformationally constrained adamantane 2-oxazoline building blocks 1-4 were synthesized and their antimicrotubule and antitrypanosomal potency was investigated. Although most of the new compounds affect tubulin polymerization, this does not make a major contribution to trypanocidal activity.

SYNTHESIS OF SPIRO 3,7>DECANE>

The synthesis of spiro3,7>decane, a novel heterocyclic system is described.

Substituted spiro[oxazolidine-5,2'-adamantane] compounds

Substituted spiro[oxazolidine-5,2'-adamantane] compounds are described.