28561-75-3Relevant academic research and scientific papers
AMIDE DERIVATIVES AS SIRTUIN MODULATORS
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Page/Page column 162, (2009/06/27)
Provided herein are novel sirtuin-modulating compounds represented by Structural Formula (I) and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benfit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin- modulating compound in combination with another therapeutic agent.
SYNTHESIS OF 2,5-DISUBSTITUTED 1,3,4-OXADIAZOLES FROM TRICHLOROMETHYLARENES AND ACYLHYDRAZINES
Poddubnyi, I. S.,Belen'skii, L. I.,Krayushkin, M. M.
, p. 602 - 607 (2007/10/02)
A preparative synthesis of 2,5-disubtituted 1,3,4-oxadiazoles by the reaction of trichloromethylarenes with hydrazides of carboxylic acids of the aliphatic, aromatic and heteroaromatic series in methanol or ethanol in the presence of pyridine was developed.
Triethyl phosphite mediated synthesis of indazoloquinazolinoperimidines, oxadiazoloindazoles and thiadiazoloindazoles
Reddy, V Rama Kishan,Reddy, P S N,Ratnam, C V
, p. 499 - 502 (2007/10/02)
2-(2-Aminophenyl)perimidine (1) on treatment with 2-nitrobenzaldehydes (2) in acetic acid gives 5,6-dihydro-6-(2-nitroaryl)quinazolinoperimidines (4) which on permanganate oxidation yield 6-(2-nitroaryl)quinazolinoperimidines (5). 5-on triethylphosphite (TEP) mediated deoxygenative cyclisation afford indazoloquinazolinoperimidines (6).Similarly, 5-aryl-2-(2-nitrophenyl)oxadiazoles (9) and 2-arylamino-5-(2-nitrophenyl)thiadiazoles (14) on treatment with TEP give 2-aryloxadiazoloindazoles (10) and2-(N-ethylarylamino)thiadiazoloindazoles (16) respectively.
Substitution Reactions of Phenylated Aza-heterocycles. Part 1. Nitration of 2,5-Diphenyl-1,3,4-oxadiazole: a Product Study using High Performance Liquid Chromatography
Blackhall, Alexander,Brydon, Donald L.,Saga, Anthony J. G.,Smith, David M.
, p. 773 - 777 (2007/10/02)
Contrary to a previous literature report, nitration of 2,5-diphenyl-1,3,4-oxadiazole (1) under various conditions gives a mixture of all six possible 2,5-bisnitrophenyl derivatives, which may be analysed quantitatively using high performance liquid chromatography.Nitration using nitric acid alone gives mainly the three isomers with p-nitrophenyl groups, i.e. (7), (9), and (10), whereas mixed acids and nitronium tetrafluoroborate give mainly meta-nitration products, i.e. (6), (8), and (9).Nitration of the three 2-(nitrophenyl)-5-phenyl-1,3,4-oxadiazoles also shows considerable variation of product ratio according to the conditions.
