23047-95-2

Basic information

• Product Name: 2-(5-phenyl-1,3,4-oxadiazol-2-yl)aniline
• CAS NO: 23047-95-2
• Molecular Formula: C₁₄H₁₁N₃O
• Molecular Weight: 237.2566
• Mol File: 23047-95-2.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 438.3°C at 760 mmHg
• Flash Point: 218.9°C
• Density: 1.238g/cm³
• Vapor Pressure: 7E-08mmHg at 25°C
• Refractive Index: 1.63
• CAS DataBase Reference: 2-(5-phenyl-1,3,4-oxadiazol-2-yl)aniline(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(5-phenyl-1,3,4-oxadiazol-2-yl)aniline(23047-95-2)
• EPA Substance Registry System: 2-(5-phenyl-1,3,4-oxadiazol-2-yl)aniline(23047-95-2)

Safety Data

• Hazardous Substances Data: 23047-95-2(Hazardous Substances Data)

Usage

Molecular Structure

2-(5-phenyl-1,3,4-oxadiazol-2-yl)aniline consists of an oxadiazole group attached to an aniline molecule, with a phenyl ring connected to the nitrogen atom.

Chemical Class

This compound belongs to the class of oxadiazoles, which is a group of organic compounds known for their diverse biological activities.

Biological Activities

Oxadiazoles have been found to exhibit various biological activities, including antimicrobial, antifungal, and anticancer properties.

Potential Applications

Due to its oxadiazole and phenyl groups, this compound has potential applications in medicinal chemistry, particularly in the development of new drugs for the treatment of infections, cancer, and inflammatory conditions.

Additional Properties

The presence of the phenyl group may also contribute to the potential biological activities of this compound, while oxadiazole derivatives have shown promise as potential anti-inflammatory and antioxidant agents.

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Downstream Products

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Relevant articles and documents

Electrosynthesis of 2-(1,3,4-Oxadiazol-2-yl)aniline Derivatives with Isatins as Amino-Attached C1 Sources

An intramolecular decarboxylative coupling reaction for the construction of 2-(1,3,4-oxadiazol-2-yl)aniline derivatives was developed from readily available isatins and hydrazides by virtue of electrochemistry. In this reaction, isatins were employed as amino-attached C1 sources, providing a variety of 2-(1,3,4-oxadiazol-2-yl)aniline derivatives with moderate to good yields.

Synthesis, Characterization, and Antimicrobial Activity of a Series of 2-(5-Phenyl-1,3,4-oxadiazol-2-yl)-N-[(1-aryl-1H-1,2,3-triazol-4-yl)methyl]anilines Using Click Chemistry

series of new triazolyl derived 1,3,4-oxadiazoles 7a–7l is synthesized with high yields by coppercatalyzed alkyne–azide cycloaddition reaction between a variety of substituted aryl/alkyl azides and 2-(5-phenyl-1,3,4-oxadiazol-2-yl)aniline. Structures of intermediates and the final compounds are confirmed by FTIR, 1H and 13C NMR, and Mass spectra. The synthesized compounds demonstrate moderate antibacterial activity and potent antifungal activity against the tested strains.

2,5-SUBSTITUTED OXAZOLE DERIVATIVES AS PROTEIN KINASE INHIBITORS FOR THE TREATMENT OF CANCER

Certain oxazole-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, methods of using compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions comprising compounds exhibiting ATP-utilizing enzyme inhibitory activity, are disclosed.