23047-95-2

Usage

Molecular Structure

2-(5-phenyl-1,3,4-oxadiazol-2-yl)aniline consists of an oxadiazole group attached to an aniline molecule, with a phenyl ring connected to the nitrogen atom.

Chemical Class

2-(5-phenyl-1,3,4-oxadiazol-2-yl)aniline belongs to the class of oxadiazoles, which is a group of organic compounds known for their diverse biological activities.

Biological Activities

Oxadiazoles have been found to exhibit various biological activities, including antimicrobial, antifungal, and anticancer properties.

Potential Applications

Due to its oxadiazole and phenyl groups, 2-(5-phenyl-1,3,4-oxadiazol-2-yl)aniline has potential applications in medicinal chemistry, particularly in the development of new drugs for the treatment of infections, cancer, and inflammatory conditions.

Additional Properties

The presence of the phenyl group may also contribute to the potential biological activities of 2-(5-phenyl-1,3,4-oxadiazol-2-yl)aniline, while oxadiazole derivatives have shown promise as potential anti-inflammatory and antioxidant agents.

Upstream product

• 2518-61-8 phenyl-2 (nitro-2 phenyl)-5 oxadiazole-1,3,4 
• 118-48-9 isatoic anhydride 
• 613-94-5 benzoic acid hydrazide 
• 28864-27-9 1-(2'-aminobenzoyl)-2-benzoylhydrazine 
• 65-85-0 benzoic acid 
• 1904-58-1 anthranilic acid hydrazide 
• 1663-61-2 triethoxymethylbenzene 
• 93-89-0 benzoic acid ethyl ester 
• 606-26-8 o-nitrobenzohydrazide 
• 91-56-5 indole-2,3-dione 
• 28561-75-3 N-benzoyl-N'-3-nitrobenzoylhydrazine 
• 707-07-3 orthobenzoic acid trimethyl ester 
• 1670-14-0 benzamidine monohydrochloride 
• 30909-95-6 3,4-Dihydro-2-phenyl-5H-1,3,4-benzotriazepin-5-one 

Downstream Products

• 97625-16-6 2-(2-Acetylaminophenyl)-5-phenyl-1,3,4-oxadiazole 

Relevant academic research and scientific papers

Electrosynthesis of 2-(1,3,4-Oxadiazol-2-yl)aniline Derivatives with Isatins as Amino-Attached C1 Sources

An intramolecular decarboxylative coupling reaction for the construction of 2-(1,3,4-oxadiazol-2-yl)aniline derivatives was developed from readily available isatins and hydrazides by virtue of electrochemistry. In this reaction, isatins were employed as amino-attached C1 sources, providing a variety of 2-(1,3,4-oxadiazol-2-yl)aniline derivatives with moderate to good yields.

Structure activity relationships, multidrug resistance reversal and selectivity of heteroarylphenyl ABCG2 inhibitors

An overexpression of the transmembrane ATP-binding cassette transporter G2 (ABCG2, BCRP) in cancer tissues is supposed to play a role in the multidrug resistance (MDR) of tumors resulting in an inefficient chemotherapy. Therefore, co-administration of sel

Synthesis, Characterization, and Antimicrobial Activity of a Series of 2-(5-Phenyl-1,3,4-oxadiazol-2-yl)-N-[(1-aryl-1H-1,2,3-triazol-4-yl)methyl]anilines Using Click Chemistry

series of new triazolyl derived 1,3,4-oxadiazoles 7a–7l is synthesized with high yields by coppercatalyzed alkyne–azide cycloaddition reaction between a variety of substituted aryl/alkyl azides and 2-(5-phenyl-1,3,4-oxadiazol-2-yl)aniline. Structures of intermediates and the final compounds are confirmed by FTIR, 1H and 13C NMR, and Mass spectra. The synthesized compounds demonstrate moderate antibacterial activity and potent antifungal activity against the tested strains.

Synthesis of 2,5-disubstituted 1,3,4-oxadiazoles by visible-light-mediated decarboxylation–cyclization of hydrazides and diketones

A visible-light-induced synthesis of 2,5-disubstituted 1,3,4-oxadiazoles from simple diketones and hydrazides with the assistant of the photocatalyst eosin Y catalyzed decarboxylation and cyclization under mild conditions has been discovered. The reaction tolerates a wide range of functional groups and gives a variety of valuable 1,3,4-oxadiazoles in moderate to good yields. Finally, a plausible reaction mechanism was proposed.

2,5-SUBSTITUTED OXAZOLE DERIVATIVES AS PROTEIN KINASE INHIBITORS FOR THE TREATMENT OF CANCER

Certain oxazole-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, methods of using compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions comprising compounds exhibiting ATP-utilizing enzyme inhibitory activity, are disclosed.

Synthesis and Benzodiazepine Binding Activity of a Series of Novel Triazoloquinazolin-5(6H)-ones

Investigation of tricyclic heterocycles related to the 2-arylpyrazoloquinolin-3(5H)-ones, structures with high affinity for the benzodiazepine (BZ) receptor, led to the synthesis of 2-phenyl-triazoloquinazolin-5(6H)-one, a compound wi

Reaction of 2-Aminobenzoylhydrazines with Carboxylic Acids: Formation of Quinazolin-4(3H)-one, 1,3,4-Oxadiazole and 1,3,4-Benzotriazepin-5-one Derivatives

Reactions of 2-aminobenzoylhydrazines with aliphatic acids give 1-(2'-acylaminobenzoyl)-2-acylhydrazines (4) which are cyclised to 3-amino-2-alkylquinazolin-4(3H)-ones (6).Aromatic acids react with 2-aminobenzoylhydrazines to give a mixture of 1-(2'-amino

The Chemistry of 2-Aminobenzoyl Hydrazides. 1. Effects of Orthoester Substituents on the Mode of Cyclization

Treatment of substituted 2-aminobenzoyl hydrazides with orthoesters has been found to yield different products depending upon the type of orthoester employed.Equimolar quantities of orthoester and hydrazide yield 3-amino-4(3H)-quinazolinones, whereas utilization of a two-fold excess (or greater) of orthoester yields, in some cases, 3,4-dihydro-5H-1,3,4-benzotriazepin-5-ones as minor products in addition to N-imidate esters as major products.Treatment of hydrazides with trimethyl orthobenzoate yields substituted 5-(2-aminophenyl)-1,3,4-oxadiazoles and 3,4-dihydro-5H-1,3,4-benzotriazepin-5-ones.The steric bulk of the phenyl group in trimethyl orthobenzoate effects the formation of adduct at the β-nitrogen of the hydrazide which cyclized to the oxadiazole and benzotriazepinone products.In the aliphatic orthoester series, the formation of adduct to the aromatic amino group appears to be favored which gives rise to quinazolinone and benzotriazepinone products.