286956-41-0

Upstream product

• 6310-23-2 (2E)-1-(4-chlorocyclopenta-1,3-dien-1-yl)-3-phenylprop-2-en-1-one 
• 100-52-7 benzaldehyde 
• 6310-09-4 2-acetyl-5-chlorothiophene 
• 286956-26-1 (5-Chloro-thiophen-2-yl)-(4-phenyl-1H-pyrrol-3-yl)-methanone 
• 74-88-4 methyl iodide 

Relevant academic research and scientific papers

The pyrrole moiety as a template for COX-1/COX-2 inhibitors

Aroyl- and thiophene-substituted pyrrole derivatives have been synthesized as a new class of COX-1/COX-2 inhibitors. The inhibition of COX-1 was evaluated in a biological system using bovine PMNLs as the enzyme source, whereas LPS-stimulated human monocytes served as the enzyme source for inducible COX-2. The determination of the concentration of arachidonic acid metabolites was performed by HPLC for COX-1 and RIA for COX-2. Variation of the substitution pattern led to a series of active compounds which showed inhibition for COX-1 and COX-2. Structural requirements for the development of COX-1/COX-2 inhibitors are discussed. (C) 2000 Editions scientifiques et medicales Elsevier SAS.

Antifungal agents. III. Naphthyl and thienyl derivatives of 1H-imidazol-1-yl-4-phenyl-1H-pyrrol-3-ylmethane

The in vitro antifungal activities of some naphthyl and thienyl derivatives of 1H-imidazol-1-yl-4-phenyl-1H-pyrrol-3-ylmethane against Candida albicans and Candida spp are reported. The title derivatives were prepared starting from proper arylstirylketone