6310-23-2

Usage

Uses

Used in Pharmaceutical Industry:
(E)-1-(5-chlorothiophen-2-yl)-3-phenyl-prop-2-en-1-one is used as an intermediate in the synthesis of pharmaceuticals for its anti-inflammatory and antifungal properties, contributing to the development of new drugs to treat a range of medical conditions.
Used in Agrochemical Industry:
In the agrochemical industry, (E)-1-(5-chlorothiophen-2-yl)-3-phenyl-prop-2-en-1-one is utilized as a component in the creation of various agrochemical products, potentially enhancing their effectiveness against pests and diseases in agriculture.
Used in Fragrance and Flavor Industry:
(E)-1-(5-chlorothiophen-2-yl)-3-phenyl-prop-2-en-1-one is used as a key ingredient in the production of fragrances and flavors due to its aromatic properties, adding unique scents and tastes to a variety of consumer products.

InChI:InChI=1/C13H9ClOS/c14-13-9-8-12(16-13)11(15)7-6-10-4-2-1-3-5-10/h1-9H/b7-6+

Upstream product

• 6310-09-4 2-acetyl-5-chlorothiophene 
• 100-52-7 benzaldehyde 

Downstream Products

• 286956-26-1 (5-Chloro-thiophen-2-yl)-(4-phenyl-1H-pyrrol-3-yl)-methanone 
• 1641550-63-1 C₁₃H₁₁ClN₂S 
• 286956-41-0 (5-Chloro-thiophen-2-yl)-(1-methyl-4-phenyl-1H-pyrrol-3-yl)-methanone 
• 188782-72-1 1-(5-chloro-2-thienyl)-4,4-dicyano-3-phenylbutanone 

Relevant academic research and scientific papers

An efficient synthesis of thiophene conjugated benzothiazepines: In vitro screening for their antimicrobial activity

A series of novel thiophene conjugated benzothiazepines were synthesized by the reaction of chalcones with 2-aminobenzenethiol in citrus juice medium. The new compounds were characterized by spectroscopic studies. Results of in vitro antimicrobial evaluation of newly synthesized compounds 5a-j shows that the compounds 5a and 5c have excellent antimicrobial inhibition in the range of 12.5-25.0 μg/ mL against bacteria S. aureus, E. coli, P. aeruginosa and fungi A. niger, A. flavus organisms comparable to ciprofloxacin and nystatin and therefore these compounds might acts as lead molecules as antimicrobial agents.

Exploration of chlorinated thienyl chalcones: A new class of monoamine oxidase-B inhibitors

Chalcone has been reported to be a valid scaffold for the design of monoamine oxidase (MAO) inhibitors. This scenario has amplified the momentum for the discovery of heteroaryl based chalcone MAO inhibitors. In the present study, we have synthesized a ser

SOCl2 catalyzed cyclization of chalcones: Synthesis and spectral studies of some bio-potent 1H pyrazoles

Some aryl-aryl 1H pyrazoles have been synthesised by cyclization of aryl chalcones and hydrazine hydrate in the presence of SOCl2. The yields of the pyrazoles are more than 85%. These pyrazoles are characterized by their physical con

The pyrrole moiety as a template for COX-1/COX-2 inhibitors

Aroyl- and thiophene-substituted pyrrole derivatives have been synthesized as a new class of COX-1/COX-2 inhibitors. The inhibition of COX-1 was evaluated in a biological system using bovine PMNLs as the enzyme source, whereas LPS-stimulated human monocytes served as the enzyme source for inducible COX-2. The determination of the concentration of arachidonic acid metabolites was performed by HPLC for COX-1 and RIA for COX-2. Variation of the substitution pattern led to a series of active compounds which showed inhibition for COX-1 and COX-2. Structural requirements for the development of COX-1/COX-2 inhibitors are discussed. (C) 2000 Editions scientifiques et medicales Elsevier SAS.