28746-99-8

Basic information

• Product Name: 1'-Hydroxy-[1,1'-bi(cyclohexan)]-2-one
• Synonyms: 1'-Hydroxy-[1,1'-bi(cyclohexan)]-2-one;2-(1-hydroxycyclohexyl)cyclohexanone;2-(1-hydroxycyclohexyl)cyclohexan-1-one;1'-hydroxy-1,1'-bi(cyclohexyl)-2-one;1'-hydroxybi(cyclohexan)-2-one
• CAS NO: 28746-99-8
• Molecular Formula: C₁₂H₂₀O₂
• Molecular Weight: 196.286
• Mol File: 28746-99-8.mol
• Article Data: 16

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 1'-Hydroxy-[1,1'-bi(cyclohexan)]-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1'-Hydroxy-[1,1'-bi(cyclohexan)]-2-one(28746-99-8)
• EPA Substance Registry System: 1'-Hydroxy-[1,1'-bi(cyclohexan)]-2-one(28746-99-8)

Safety Data

• Hazardous Substances Data: 28746-99-8(Hazardous Substances Data)

Usage

General Description

1'-Hydroxy-[1,1'-bi(cyclohexan)]-2-one is a specific type of organic compound that falls under the category of ketones. It contains a carbonyl group (C=O) and at least two other carbon atoms, each within a cyclohexane ring. The ‘1'-Hydroxy’ part of the name refers to a hydroxyl group (-OH) attached to the first carbon of the molecule. This chemical compound is often used in various laboratory research and synthesis processes due to its unique chemical properties. Like all ketones, it has diverse industrial applications, particularly in the pharmaceutical industry and the production of various resins and plastics. However, its specific properties, safety measures, and exact applications may vary depending on the context.

Upstream product

• 108-94-1 cyclohexanone 
• 1502-22-3 2-(1-cyclohexenyl)cyclohexanone 
• 1011-12-7 2-cyclohexylidenecyclohexanone 
• 2612-42-2 (dibromomethyl)trimethylsilane 
• 10468-40-3 cyclohexanone N-cyclohexylimine 
• 75-77-4 chloro-trimethyl-silane 
• 6651-36-1 1-(Trimethylsilyloxy)cyclohexene 
• 124-38-9 carbon dioxide 
• 74-88-4 methyl iodide 
• 56974-20-0 2-bromocyclohex-1-enyl acetate 
• 140112-10-3 C₁₈H₃₁BO 
• 502-42-1 cycloheptanone 
• 67-64-1 acetone 
• 120-92-3 cyclopentanone 

Downstream Products

• 1266333-69-0 2-phenyl-5,6,7,8,9,10,11,12-octahydro[1,2,4]triazino[1,6-f ]-phenanthridin-13-ium-4-olate 
• 1502-22-3 2-(1-cyclohexenyl)cyclohexanone 
• 108-94-1 cyclohexanone 
• 1011-12-7 2-cyclohexylidenecyclohexanone 

Relevant articles and documents

BIS(BROMOMAGNESIO)TRIMETHYLSILYLMETHANE

The reaction of Me3SiCH(MgBr)2 with magnesium amalgam in diisopropyl ether furnished the di-Grignard reagent Me3SiCH(MgBr)2 in 70 percent yield.Derivatization with Me3SnCl gave Me3SiCH(SnMe3)2 (6,94percent).Witting type reaction occured readily with benzophenone (80percent), but the yield was low with cyclohexanone (13percent).

Reactivity of Lithium β-Ketocarboxylates: The Role of Lithium Salts

Lithium β-ketocarboxylates 1(COOLi), prepared by the reaction of lithium enolates 2(Li+) with carbon dioxide, readily undergo decarboxylative disproportionation in THF solution unless in the presence of lithium salts, in which case they are indefinitely stable at room temperature in inert atmosphere. The availability of stable THF solutions of lithium β-ketocarboxylates 1(COOLi) in the absence of carbon dioxide allowed reactions to take place with nitrogen bases and alkyl halides 3 to give α-alkyl ketones 1(R) after acidic hydrolysis. The sequence thus represents the use of carbon dioxide as a removable directing group for the selective monoalkylation of lithium enolates 2(Li+). The roles of lithium salts in preventing the disproportionation of lithium β-ketocarboxylates 1(COOLi) and in determining the course of the reaction with bases and alkyl halides 3 are discussed.

Mass spectrometric studies of self-condensation products of cyclohexanone under alkaline conditions and synthesis of dodecahydrotriphenylene and triphenylene from easily available reactants

LC-MS was used to study products of cyclohexanone self-condensation under alkaline conditions. Improved methods (as compared to those described in the literature) for the preparation of dodecahydrotriphenylene and highly pure sublimed triphenylene were suggested based on the easily available and cheap reactants. Possible reasons of the low yield of the target dodecahydrotriphenylene in the step of oligomerization of cyclohexanone were identified.