28767-76-2

Upstream product

• 100-52-7 benzaldehyde 
• 5705-16-8 N-benzyl-N-(p-methylphenyl)hydrazine 
• 100-44-7 benzyl chloride 
• 539-44-6 N-4-methylphenylhydrazine 
• 637-60-5 p-tolylhydrazine hydrochloride 
• 100-39-0 benzyl bromide 
• 1858-99-7 benzaldehyde p-tolylhydrazone 
• 106-49-0 p-toluidine 
• 588-64-7 benzaldehyde phenylhydrazone 
• 2725-46-4 1-benzyl-2-benzylidene-1-phenylhydrazine 

Downstream Products

• 39235-95-5 1-benzyl-5-methyl-2-phenyl-1H-1,3-benzimidazole 

Relevant academic research and scientific papers

A one-pot synthesis of bisarylhydrazones by Cu(I)-catalyzed aerobic oxidation

An efficient Cu(I)-catalyzed one-pot synthesis of N-substituted (or NH) bisarylhydrazones is reported. A further cyclization reaction could occur towards the synthesis of benzimidazoles or triazoles with elevated temperature. A plausible alkylation-oxidation-alkylation mechanism is proposed based on experimental results and literature.

Copper-mediated synthesis of substituted 2-aryl-N-benzylbenzimidazoles and 2-arylbenzoxazoles via C-H functionalization/C-N/C-O bond formation

An efficient method for the transformation of N-benzyl bisarylhydrazones and bisaryloxime ethers to functionalized 2-aryl-N-benzylbenzimidazoles and 2-arylbenzoxazoles is described. The protocol involves a copper(II)-mediated cascade C-H functionalization/C-N/C-O bond formation under neutral conditions. Substrates having either electron-donating or -withdrawing substituents undergo the cyclization to afford the target heterocycles at moderate temperature.