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1,2-dihydro-6-hydroxy-1-(2-hydroxyethyl)-4-methyl-2-oxonicotinonitrile, also known as DHN-MNO, is a chemical compound that belongs to the class of nicotinamide metabolites. It is an intermediate in the biosynthesis of the molybdenum cofactor, which is essential for the activity of molybdenum-dependent enzymes. DHN-MNO has been identified as a potent inhibitor of the enzyme aldehyde oxidase, and has shown potential therapeutic effects in the treatment of various diseases, including cancer and neurodegenerative disorders. Its structure and properties make it a promising candidate for further research and development in the field of medicinal chemistry.

28799-82-8

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28799-82-8 Usage

Uses

Used in Pharmaceutical Industry:
1,2-dihydro-6-hydroxy-1-(2-hydroxyethyl)-4-methyl-2-oxonicotinonitrile is used as a therapeutic agent for the treatment of various diseases, such as cancer and neurodegenerative disorders, due to its potential to inhibit the enzyme aldehyde oxidase and its involvement in the biosynthesis of the molybdenum cofactor.
Used in Medicinal Chemistry Research:
1,2-dihydro-6-hydroxy-1-(2-hydroxyethyl)-4-methyl-2-oxonicotinonitrile is used as a research compound for further exploration of its structure, properties, and potential applications in the development of new drugs and therapies. Its unique chemical characteristics and biological activities make it a valuable subject for scientific investigation and innovation in the field of medicinal chemistry.

Check Digit Verification of cas no

The CAS Registry Mumber 28799-82-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,8,7,9 and 9 respectively; the second part has 2 digits, 8 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 28799-82:
(7*2)+(6*8)+(5*7)+(4*9)+(3*9)+(2*8)+(1*2)=178
178 % 10 = 8
So 28799-82-8 is a valid CAS Registry Number.
InChI:InChI=1/C9H10N2O3/c1-6-4-8(13)11(2-3-12)9(14)7(6)5-10/h4,12,14H,2-3H2,1H3

28799-82-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-hydroxy-1-(2-hydroxyethyl)-4-methyl-6-oxopyridine-3-carbonitrile

1.2 Other means of identification

Product number -
Other names 3-cyano-6-hydroxy-1-(2-hydroxyethyl)-4-methyl-2(1H)-pyridinone

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:28799-82-8 SDS

28799-82-8Downstream Products

28799-82-8Relevant academic research and scientific papers

Continuous flow synthesis of some 6- And 1,6-substituted 3-cyano-4-methyl-2-pyridones

Tadi?, Julijana,Mihajlovi?, Marina,Jovanovi?, Mi?a,Mijin, Du?an

, p. 531 - 538 (2019/08/30)

In this study, six 6- and 1,6-substituted-3-cyano-4-methyl-2-pyri-dones were synthesized in a continuous flow microreactor system. The syntheses were realized at room temperature and the obtained results were compared to those achieved within classical syntheses. In order to optimize the continuous flow syntheses and increase the yield of the products, the retention time in the microreactor was varied by changing the flow rates of the reactant solutions. Furthermore, the reaction was optimized for 3-cyano-4,6-dimethyl-2-pyridone and 3-cyano-6-hydroxy-4-methyl-2-pyridone, which are comercially important in the pharmaceutical and dye industries. Both 2-pyridones were obtained in satisfactory yield of circa 60 % in less than 10 min. The resulting compounds were characterized by their melting points, FT-IR, 1H-NMR and UV–Vis spectra. The efficiency of the presented method for the synthesis of 2-pyridone-based molecules has promising potential for industrial production.

Pyridine the alkone is wrong compound compound

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Page/Page column 44; 45, (2018/08/02)

PURPOSE: A pyridone complex compound and dye containing the same are provided to ensure high molar extinction coefficient. CONSTITUTION: A compound is denoted by formula 0. In formula 0, R^1 is monovalent saturated hydrocarbon group of 1-8 carbon atoms; R^2 is hydrogen atom, -CN, or -CONH_2 group; R^3 is alkyl group of 1-4 carbon atoms; and R^8 and R^9 are independently hydrogen atom, monovalent aliphatic hydrocarbon group of 1-8 carbon atoms, aralyl group of 7-12 carbon atoms, or monovalent aromatic hydrocarbon group of 6-10 carbon atoms.

Yellow dye composition for a color filter

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Paragraph 0077-0082, (2017/04/29)

The present invention relates to a yellow dye composition for a color filter comprising a compound represented by chemical formula 1 as a coloring agent. The yellow dye composition can be used in a color filter due to excellent heat resistance and solubility. In chemical formula 1, R1 to R6 are the same as described in the detailed description of the present invention.COPYRIGHT KIPO 2017

Pyridine the alkone is wrong compound compound

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Page/Page column 33, (2016/10/08)

PURPOSE: A pyridone complex compound and a coloring resin composition are provided to ensure high spectral concentration and to be used in a color filter. CONSTITUTION: A pyridione complex compound is denoted by formula 0 or I. An azo compound is prepared by diazo coupling of diazonium salt with pyridone compounds. The diazonuim salt is prepared by diazotization of amine by nitrous acid, nitrite, or nitrous ether. A dye contains the pyridone complex compound as an active ingredient. A coloring resin composition contains the dye containing the pyridone complex compound, resin, and solvent.

Compound (by machine translation)

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Page/Page column 31, (2016/10/08)

A is represented by formula (I) compound that expressed by: (I) [Formula (I) in, R1 represents a hydrogen atom or may have substituted carbon numbers of the base 1-30 one monovalent hydrocarbyl, the hydrocarbyl in the-CH2-can be formed by-O-or-CO-substituent; R2 represents a hydrogen atom, cyano or amine formyl ; R3 stands for 1-4 the alkyl, the alkyl in the contained hydrogen atom can be formed by a halogen atom substituted; R4-R8 mutually independently represents a hydrogen atom, the carbon number 1-8 the alkyl group, the carbon number 1-8 alkoxyl, carbon number 2-8 alkoxyl alkyl, hydroxy, cyano, nitro, a halogen atom or a formula (Ia) the expressed the base, at least 1 one representative of the (Ia) the yl]; (Ia) [Type (Ia) in, L1 stands for 1-8 alkane two bases of]. (by machine translation)

Pyridine the alkone is wrong compound compound

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Page/Page column 54, (2016/10/09)

PURPOSE: A compound used as a dye is provided to enhance high molar extinction coefficient and spectrometric concentrate. CONSTITUTION: A compound is denoted by chemical formula (0). In chemical formula (0), R2 is hydrogen atom, -CN, or -CONH_2; R3 is alkyl group of 1-4 carbon atoms; and R4a-R7a are independently -R^8, OR^8, -COOR^8, -COR^8, -OCOOR^8, -OCOR^8, -CN, -NO^2, halogen atom, -SO_3H, -SO_3Na,-SO_3K, -SO_2NR, 8R9, or -NR^ll R^12. A dye contains the compound as an active ingredient. A coloring resin composition contains the dye, resin, and solvent.

Dye salt (by machine translation)

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Page/Page column 47, (2016/10/09)

This invention is a kind of type (0) to express perabrodil due to high absorbance, the concentration of said light units are removed the concentration of the high concentration, in particular can be used as a liquid crystal display device of the display device of the dye for color filter use. (0) (by machine translation)

A SALT FOR DYE

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Page/Page column 60, (2016/10/31)

PURPOSE: A salt for dye is provided to enhance spectral concentration showing color depth of unit concentrate and to use the dye for a color filter. CONSTITUTION: A salt of formula (0) contains anion of formula (A1) and cation of formula (A2). The anion (A1) is selected according to the color of a target color filter. The salt containing the anion (A1) is enough dissolved in a solvent.

Compound and contain the coloration photosensitive resin composition

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Page/Page column 28; 29, (2017/01/02)

The compound which is represented in a formula (I) can be used as a dye contained in a colored photosensitive resin composition because of large molar absorptivity. In the formula (I), at least one selected from R4-R8 represents nitryl, and at least one represents SO3M.

Pyridine compounds

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Page/Page column 30, (2021/05/17)

A pyridinone compound, a dye with the pyridinone compound as an effective component, and a colored resin composition comprising the dye with the pyridinone compound as an effective component, a resin, and a solvent.

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