289038-14-8

Basic information

• Product Name: 2-BROMO-4-FLUOROBENZYLAMINE HYDROCHLORIDE
• Synonyms: 2-BROMO-4-FLUOROBENZYLAMINE HYDROCHLORIDE;(2-Bromo-4-fluorophenyl)methylamine hydrochloride;(2-bromo-4-fluorophenyl)methanamine hydrochloride
• CAS NO: 289038-14-8
• Molecular Formula: C₇H₇BrFN*ClH
• Molecular Weight: 240.5
• Product Categories: Anilines, Amides & Amines;Bromine Compounds;Fluorine Compounds
• Mol File: 289038-14-8.mol
• Article Data: 2

Chemical Properties

• Melting Point: 251 °C(Solv: ethyl ether (60-29-7))
• Boiling Point: 244.4°C at 760 mmHg
• Flash Point: 101.6°C
• Appearance: /Solid
• Vapor Pressure: 0.0305mmHg at 25°C
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: 2-BROMO-4-FLUOROBENZYLAMINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BROMO-4-FLUOROBENZYLAMINE HYDROCHLORIDE(289038-14-8)
• EPA Substance Registry System: 2-BROMO-4-FLUOROBENZYLAMINE HYDROCHLORIDE(289038-14-8)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 289038-14-8(Hazardous Substances Data)

Usage

Uses

2-Bromo-4-fluorobenzylamine hydrochloride used as a intermediate in pharmaceutical.

InChI:InChI=1/C7H7BrFN.ClH/c8-7-3-6(9)2-1-5(7)4-10;/h1-3H,4,10H2;1H

Upstream product

• 1006-41-3 2-bromo-4-fluorobenzoic acid 
• 1006-40-2 2-bromo-4-fluorobenzamide 
• 36282-26-5 2-bromo-4-fluorobenzonitrile 
• 530141-41-4 2-[(2-bromo-4-fluorophenyl)methyl]-1H-isoindole-1,3(2H)-dione 

Downstream Products

• 1293323-83-7 (2-bromo-4-fluorobenzyl)(cyclohex-2-enyl)carbamic acid tert-butyl ester 

Relevant articles and documents

Rapid synthesis and zebrafish evaluation of a phenanthridine-based small molecule library

A Heck cyclisation approach is described for the rapid synthesis of a library of natural product-like small molecules, based on the phenanthridine core. The synthesis of a range of substituted benzylamine building blocks and their incorporation into the library is reported, together with a highly selective cis-dihydroxylation protocol that enables access to the target compounds in an efficient manner. Biological evaluation of the library using zebrafish phenotyping has led to the discovery of compound 20c, a novel inhibitor of early-stage zebrafish embryo development.