2893-13-2

Usage

General Description

2,3-bis(4-chlorophenyl)prop-2-enoic acid, also known as chlordimeform, is a chemical compound that belongs to the class of organic compounds known as phenylpropanoic acids. It is commonly used as an insecticide and acaricide in agriculture. Chlordimeform works by disrupting the nervous system of insects and mites, leading to their paralysis and eventual death. It is particularly effective against pests such as aphids, mites, and whiteflies. However, due to its potential toxicity and environmental concerns, its use has been restricted or banned in many countries. Exposure to chlordimeform can lead to adverse health effects in humans and animals, and it has been classified as a possible human carcinogen by the International Agency for Research on Cancer (IARC). Therefore, its production and use are now limited in many parts of the world.

Upstream product

• 1878-66-6 4-chlorophenylacetic Acid 
• 104-88-1 4-chlorobenzaldehyde 
• 124-38-9 carbon dioxide 
• 1820-42-4 bis(4-chlorophenyl)acetylene 

Relevant academic research and scientific papers

Synthesis of Vinyl Carboxylic Acids using Carbon Dioxide as a Carbon Source by Iron-Catalyzed Hydromagnesiation

An iron-catalyzed synthesis of α,β-unsaturated carboxylic acids from alkynes and carbon dioxide was developed. This reaction proceeds through hydromagnesiation of alkynes followed by carbon dioxide insertion under atmospheric pressure and ambient temperature in the presence of iron and a Grignard reagent as a catalyst and hydride source, respectively. Several symmetrical and unsymmetrical alkynes were transformed into the corresponding acids in good to excellent yields. The methodology provides an efficient route to the synthesis of vinyl carboxylic acids.

GUANIDINE DERIVATIVES AS TRPC MODULATORS

The present invention is directed to guanidine derivatives as inhibitors of transient receptor potential canonical channels (TRPC channels), in particular TRPC3 and/or TRPC6 and/or TRPC7 activity, more particularly TRPC6 activity. Also provided herein are processes for preparing compounds described herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders mediated by TRPC channels (Formula (I))