2893-49-4

Usage

Uses

Used in Medical and Dental Practices:
NSC45488 is used as an antiseptic and disinfectant for its proven antibacterial and antiviral properties, contributing to the prevention of infections in medical and dental settings.
Used in Mouthwash:
NSC45488 is used as an active ingredient in mouthwash products to maintain oral hygiene and prevent oral infections by targeting harmful bacteria and viruses.
Used in Wound Dressings:
NSC45488 is used as a component in wound dressings to promote healing and prevent infection by killing bacteria and viruses that may contaminate the wound.

InChI:InChI=1/C6H15NO/c1-6(2)7(3)4-5-8/h6,8H,4-5H2,1-3H3

Upstream product

• 75-21-8 oxirane 
• 4747-21-1 N-methylpropan-2-amine 
• 76441-71-9 (2-Hydroxy-ethyl)-isopropyl-methoxymethyl-methyl-ammonium; bromide 
• 67-56-1 methanol 
• 109-56-8 i-propyl(2-(hydroxy)ethyl)amine 
• 74-88-4 methyl iodide 
• 50-00-0 formaldehyd 
• 64-18-6 formic acid 

Downstream Products

• 92331-09-4 2-<2-(Methyl-isopropyl-amino)-ethoxy>-1-phenyl-ethanol-(1) 

Relevant academic research and scientific papers

Continuous chemoselective methylation of functionalized amines and diols with supercritical methanol over solid acid and acid-base bifunctional catalysts

The selective N-methylation of bifunctionalized amines with supercritical methanol (scCH3OH) promoted by the conventional solid acids (H-mordenite, β-zeolite, amorphous silica-alumina) and acid-base bifunctional catalysts (Cs-P-Si mixed oxide and γ-alumina) was investigated in a continuous-flow, fixed-bed reactor. The use of scCH 3OH in the reaction of 2-aminoethanol with methanol (amine/CH 3OH = 1/10.8) over the solid catalysts led to a significant improvement in the chemoselectivity of the N-methylation. Among the catalysts examined, the Cs-P-Si mixed oxide provided the most efficient catalyst performance in terms of selectivity and reactivity at 300 °C and 8.2 MPa; the N-methylation selectivity in the products reaching up to 94% at 86% conversion. The present selective methylation was successfully applied to the synthesis of N-methylated amino alcohols and diamines as well as O-methylated ethylene glycol. Noticeably, ethoxyethylamine was less reactive, suggesting that the hydroxy group of the amino alcohols is a crucial structural factor in determining high reactivity and selectivity, possibly because of the tethering effect of another terminus, a hydroxo group, to the catalyst surface. The magic-angle-spinning NMR spectroscopy and X-ray diffraction analysis of the Cs-P-Si mixed oxide catalyst revealed that the acidic and basic sites originate from P2O5/SiO2 and Cs/SiO2, respectively, and the weak acid-base paired sites are attributed to three kinds of cesium phosphates on SiO2. The weak acid-base sites on the catalyst surface might be responsible for the selective dehydrative methylation.

Enhanced product selectivity in continuous N-methylation of amino alcohols over solid acid-base catalysts with supercritical methanol

The unique properties of supercritical fluids can be exploited for fine-tuning product selectivity. Under the conditions listed for the N-methylation of amino alcohols (see scheme) over solid acid-base bifunctional catalysts, the total yield and product selectivity could be improved. Enhanced product selectivity might be attributed to the milder reaction conditions possible with supercritical methanol, as well as the increased concentration of methanol on the catalyst.

CLEAVAGE OF N-METHOXYMETHYLAMMONIUM SALTS. III. TRANSFORMATION OF AMMONIUM SALT DERIVATIVES OF ALIPHATIC AMINO ALCOHOLS IN DIMETHYL SULFOXIDE

The dealkylation of methoxymethyl quaternary ammonium salts of some aliphatic amino alcohols in DMSO leads to the simultaneous formation of the hydrohalides of methyl(aminoalkyl)formals and the corresponding amino alcohols.The formals are formed by an intermolecular mechanism.