289903-50-0

Basic information

• Product Name: tert-butyl N-[4-(2-azidoethoxy)-3-methoxybenzyl]carbamate
• Synonyms: tert-butyl N-[4-(2-azidoethoxy)-3-methoxybenzyl]carbamate
• CAS NO: 289903-50-0
• Molecular Weight: 322.364
• Mol File: 289903-50-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: tert-butyl N-[4-(2-azidoethoxy)-3-methoxybenzyl]carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl N-[4-(2-azidoethoxy)-3-methoxybenzyl]carbamate(289903-50-0)
• EPA Substance Registry System: tert-butyl N-[4-(2-azidoethoxy)-3-methoxybenzyl]carbamate(289903-50-0)

Safety Data

• Hazardous Substances Data: 289903-50-0(Hazardous Substances Data)

Upstream product

• 1196-92-5 Vanillylamin 
• 130972-89-3 (4-hydroxy-3-methoxybenzyl)carbamic acid tert-butyl ester 
• 7149-10-2 vanillylamine hydrochloride 
• 24424-99-5 di-tert-butyl dicarbonate 
• 130972-90-6 tert-butyl N-[4-(2-bromoethoxy)-3-methoxybenzyl]carbamate 

Downstream Products

• 289903-60-2 2,2-Dimethyl Propionic Acid 2-{3-[4-(2-Azidoethoxy)-3-methoxybenzyl]thioureido Methyl}-3-(4-t-butylphenyl)propyl Ester 
• 289903-58-8 2,2-Dimethyl Propionic Acid 2-{3-[4-(2-Azidoethoxy)-3-methoxybenzyl]thioureido Methyl}-3-(3,4-dimethylphenyl)propyl ester 
• 289903-56-6 4-(2-azidoethoxy)-3-methoxybenzylisothiocyanate 

Relevant articles and documents

The SAR analysis of TRPV1 agonists with the α-methylated B-region

A series of TRPV1 agonists with amide, reverse amide, and thiourea groups in the B-region and their corresponding α-methylated analogues were investigated. Whereas the α-methylation of the amide B-region enhanced the binding affinities and potencies as agonists, that of the reverse amide and thiourea led to a reduction in receptor affinity. The analysis indicated that proper hydrogen bonding as well as steric effects in the B-region are critical for receptor binding.