289906-68-9

Upstream product

• 16077-10-4 N-benzyl-5-methoxyisatin 
• 1774-47-6 trimethylsulfoxonium iodide 
• 65836-82-0 1-benzyl-2,3-dihydro-5-methoxy-1H-indol-2-one 
• 106-93-4 ethylene dibromide 
• 100-39-0 benzyl bromide 
• 39755-95-8 5-methoxyisatine 

Downstream Products

• 289906-69-0 1-benzyl-5-methoxy-1'-methyl-1H-spiro[indole-3,3'-pyrrolidin]-2-one 

Relevant academic research and scientific papers

Efficient synthesis of (±)-horsfiline through the MgI2-catalyzed ring- expansion reaction of a spiro[cyclopropane-1,3'-indol]-2'-one

We report a short synthetic route to (±)-horsfiline that provides the racemate in five steps from commercially available, substituted isatin in 41% overall yield. Efficient entry into the spiro[oxindole-pyrrolidine] ring system is possible through the application of the cyclopropane opening/ring expansion chemistry we have described with MgI2 as a bifunctional catalyst.

Domino Corey-Chaykovsky Reaction for One-Pot Access to Spirocyclopropyl Oxindoles

The development of the sequential Corey-Chaykovsky reactions of isatins, spiroepoxy-, or spiroaziridine oxindoles with sulfur ylide has led to the discovery of a unique reaction mode that allows easy and direct one-pot access to a range of spirocyclopropyl oxindoles.