2903-20-0

Upstream product

• 19980-35-9 1-trimethylsilyloxy-2-methyl-1-cyclohexene 
• 96-32-2 bromoacetic acid methyl ester 
• 583-60-8 2-Methylcyclohexanone 
• 58711-31-2 (1-methyl-2-oxo-cyclohexyl)-acetic acid 
• 74-88-4 methyl iodide 
• 85920-95-2 (1-Methyl-2-oxo-cyclohexyl)-phenylsulfanyl-acetic acid methyl ester 

Downstream Products

• 106464-80-6 ((1R,4R)-4-Allyl-1-methyl-2-oxo-cyclohexyl)-acetic acid methyl ester 
• 106464-80-6 ((1R,4S)-4-Allyl-1-methyl-2-oxo-cyclohexyl)-acetic acid methyl ester 

Relevant academic research and scientific papers

1,4-DIASTEREOSELECTIVITY IN THE ADDITION OF ALLYLSTANNANES TO 1-ALKYL-2-OXOCYCLOHEX-3-ENEACETIC ACID METHYL ESTERS

Cyclohexanones 1 were allowed to react with allyltrimethylsilane and three allyltributylstannanes in the presence of titanium tetrachloride.Products 2 and 3 were formed in ratios ranging from 7:1 to 26:1 (2:3).Ratios resulting from the use of other Lewis acids support 4 as an intermediate which accounts for the observed stereoselectivity.

THE METHOXYCARBONYLALKYLATION AND METHOXYCARBONYLALKYLIDENATION OF SILYL ENOL ETHERS

Silyl enol ethers (1) react with the phenylthio(methoxycarbonyl)alkyl chlorides (2) in the presence of Lewis acids to give good yields of the γ-ketoesters (3); oxidative and reductive desulphurisations give the saturated (4) and unsaturated (5 or 6) γ-ket

Fluoride-Mediated Reactions of Enol Silyl Ethers. Regiospecific Monoalkylation of Ketones

Treatment of enol silyl ethers with alkyl halides in the presence of benzyltrimethylammonium fluoride and molecular sieves at room temperature gives the corresponding monoalkylated products with high regiospecificity.In most cases no polyalkylated products formed in the reaction.The alkylation reaction is highly chemospecific: esters, epoxides, and even ketones survive the reaction conditions.The reactions of various cyclohexanone derivatives proceed with the preferential axial attack of the electrophile.

Cycloalkanoindoles. I. Synthesis and antiinflammatory actions of some acidic tetrahydrocarbazoles, cyclopentindoles, and cycloheptindoles

A novel series of acidic cycloalkanoindoles comprising tetrahydrocarbazole, cyclopentindole, and cycloheptindole 1 acetic acids has been synthesized via the Fischer indolization between a phenylhydrazine and a 1 alkyl 2 oxocycloalkaneacetic acid ester. Th