2904-67-8

Basic information

• Product Name: 1-phenyl-3-(2,4,6-trimethylphenyl)urea
• Synonyms: 1-Mesityl-3-phenylurea; urea, N-phenyl-N'-(2,4,6-trimethylphenyl)-
• CAS NO: 2904-67-8
• Molecular Formula: C₁₆H₁₈N₂O
• Molecular Weight: 254.3269
• Mol File: 2904-67-8.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 305.5°C at 760 mmHg
• Flash Point: 93.2°C
• Density: 1.163g/cm³
• Vapor Pressure: 0.000818mmHg at 25°C
• Refractive Index: 1.647
• CAS DataBase Reference: 1-phenyl-3-(2,4,6-trimethylphenyl)urea(CAS DataBase Reference)
• NIST Chemistry Reference: 1-phenyl-3-(2,4,6-trimethylphenyl)urea(2904-67-8)
• EPA Substance Registry System: 1-phenyl-3-(2,4,6-trimethylphenyl)urea(2904-67-8)

Safety Data

• Hazardous Substances Data: 2904-67-8(Hazardous Substances Data)

Usage

Physical appearance

White crystalline the compound forms solid crystals that are white in color.

Solubility

Sparingly soluble in water the compound does not dissolve easily in water.

Usage

Reagent in organic synthesis PTU is often used as a reagent to help create other organic compounds in chemical reactions.

Properties

Anti-microbial and anti-inflammatory PTU has been shown to possess properties that can inhibit the growth of microorganisms and reduce inflammation.

Biological research application

Thyroid peroxidase inhibitor PTU is used in the study of thyroid function and autoimmune thyroid disease, as it can inhibit the activity of thyroid peroxidase, an enzyme involved in thyroid hormone production.

Upstream product

• 103-71-9 phenyl isocyanate 
• 88-05-1 2,4,6-trimethylaniline 
• 98-88-4 benzoyl chloride 
• 480-63-7 mesitylenecarboxylic acid 
• 62-53-3 aniline 
• 201230-82-2 carbon monoxide 
• 622-37-7 Phenyl azide 
• 2904-57-6 mesitylenecarbonitrile oxide 
• 63133-66-4 3-phenyl-4-(2,4,6-trimethyl-phenyl)-3H-[1,2,3,5]oxathiadiazole 2-oxide 
• 3023-19-6 N-hydroxy-2,4,6-trimethyl-N'-phenyl-benzamidine 
• 72340-27-3 N-(2,4,6-Trimethyl-phenyl)-benzamidine 
• 37143-74-1 1-mesityl-3-phenylthiourea 
• 2958-62-5 mesityl isocyanate 
• 60986-29-0 N-(2,4,6-trimethylphenyl)-N′-phenylcarbodiimide 

Relevant articles and documents

Hydroamination and Hydrophosphination of Isocyanates/Isothiocyanates under Catalyst-Free Conditions

Symmetrical and unsymmetrical N,N’-disubstituted as well as trisubstituted ureas/thioureas by the hydroamination of isocyanates/isothiocyanates, and various phosphathioureas by the hydrophosphination of isothiocyanates have been synthesized in good to excellent yields under catalyst-free and mild conditions. This protocol is also applicable for the efficient synthesis of chiral ureas and thioureas and common herbicides, such as fenuron and monuron.

An efficient one-pot synthesis of N,N′-disubstituted phenylureas and N-aryl carbamates using hydroxylamine-O-sulfonic acid

We have developed an efficient one-pot method for the microwave-assisted synthesis of ureas and carbamates via a proposed Lossen rearrangement. Herein we report the first examples of the direct conversion of benzoyl chlorides into N,N′-disubstituted ureas and N-aryl carbamates using hydroxylamine-O-sulfonic acid as reagent. Using our general method, we have produced 11 examples of N,N′-disubstituted phenylureas in yields up to 95% using various substituted anilines, and primary and secondary amines. Additionally, we were able to generate a series of N-aryl carbamates in moderate yields using primary, secondary and tertiary alcohols.

Imidazolin-2-iminato Ligand-Supported Titanium Complexes as Catalysts for the Synthesis of Urea Derivatives

The reactions of tetrakis(dimethylamido)titanium(IV) [Ti(NMe2)4] with three different imidazolin-2-imines (ImRNH; R = tert-butyl (tBu), mesityl (Mes), and 2,6-diisopropylphenyl (Dipp)) afforded the corresponding titanium i