2907-92-8

Usage

Uses

Used in Cosmetic and Personal Care Products:
Triethyl 2-methylpropane-1,1,3-tricarboxylate is used as a flavor and fragrance ingredient in cosmetic and personal care products due to its pleasant aroma. Its fruity, sweet scent adds a desirable quality to these products, enhancing the sensory experience for consumers.
Used in Industrial Applications:
Triethyl 2-methylpropane-1,1,3-tricarboxylate is also used as a solvent in various industrial applications. Its low boiling point and solubility properties make it suitable for use in a wide range of processes, including the manufacturing of coatings, adhesives, and other chemical products.
Production:
Triethyl 2-methylpropane-1,1,3-tricarboxylate is produced through esterification, a chemical reaction between an alcohol and a carboxylic acid. This process results in the formation of the ester compound, which can then be used in various applications across different industries.

Upstream product

• 1462-12-0 diethyl ethylidenemalonate 
• 105-36-2 ethyl bromoacetate 
• 996-82-7 sodium diethylmalonate 
• 10544-63-5 ethyl crotonate 
• 105-53-3 diethyl malonate 
• 623-70-1 ethyl (E)-crotonate 
• 623-43-8 crotonic acid methyl ester 
• 996-82-7 sodium diethylmalonate 

Downstream Products

• 1128-08-1 dihydro-cis-jasmone 
• 488-10-8 cis-jasmone 
• 626-51-7 3-methyl glutaric acid 

Relevant academic research and scientific papers

Asymmetric michael addition catalyzed by aluminum lithium bis-(R)-binaphthoxide

Enantiomerically pure aluminum lithium bis-(R)-binaphthoxide [(R)-ALB] was synthesized and used to catalyze asymmetric Michael addition of diethyl malonate to ethyl crotonate.

Method for synthesizing muscone by utilizing beta-monomethyl methylglutarate

The invention discloses a method for synthesizing muscone by utilizing beta-monomethyl methylglutarate. According to the method, beta-monomethyl methylglutarate and alpha,omega-dodecanedioic acid monomethyl ester respectively prepared through a heteropoly acid catalytic transesterification method are used as raw materials, and Kolbe electrolysis, acyloin condensation and reduction reaction are performed to prepare the muscone. The method of the present invention has advantages of high raw material utilization rate, mold condition, easy control and environmental protection, and is suitable for industrial production .

Synthesis of Akt inhibitor ipatasertib. part 1. Route scouting and early process development of a challenging cyclopentylpyrimidine intermediate

Herein, the route scouting and early process development of a key cyclopentylpyrimidine ketone intermediate toward the synthesis of Akt inhibitor Ipatasertib are described. Initial supplies of the intermediate were prepared through a method that commenced with the natural product (R)-(+)-pulegone and relied on the early construction of a methyl-substituted cyclopentyl ring system. The first process chemistry route, detailed herein, enabled the synthesis of the ketone on a hundred-gram scale, but it was not feasible for the requisite production of multikilogram quantities of this compound and necessitated the exploration of alternative strategies. Several new synthetic approaches were investigated towards the preparation of the cyclopentylpyrimidine ketone, in either racemic or chiral form, which resulted in the discovery of a more practical route that hinged on the initial preparation of a highly substituted dihydroxypyrimidine compound. The cyclopentane ring in the target was then constructed through a key carbonylative esterification and subsequent tandem Dieckmann cyclization-decarboxylation sequence that was demonstrated in a racemic synthesis. This proof-of-concept was later developed into an asymmetric synthesis of the cyclopentylpyrimidine ketone, which will be described in a subsequent paper, along with the synthesis of Ipatasertib.